TPGS modified reduced bovine serum albumin nanoparticles as a lipophilic anticancer drug carrier for overcoming multidrug resistance

2016 ◽  
Vol 4 (22) ◽  
pp. 3959-3968 ◽  
Author(s):  
Fangcheng Chen ◽  
Jun Wu ◽  
Chunli Zheng ◽  
Jiabi Zhu ◽  
Yajie Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Anticancer Drug ◽  
Bovine Serum ◽  
Drug Carrier ◽  
Glycol Succinate ◽  
Anticancer Drug Delivery ◽  
Protein Polymer ◽  
Polymer Conjugate ◽  
Novel Protein

In this study, a novel protein–polymer conjugate, d-α-tocopheryl polyethylene glycol succinate modified reduced bovine serum albumin (TPGS–Re-BSA, TRB), was synthesized for lipophilic anticancer drug delivery, and its unique ability to overcome drug resistance was explored.

pH-sensitive hydrogels based on bovine serum albumin for anticancer drug delivery

2010 ◽  
Vol 115 (4) ◽  
pp. 2050-2059 ◽  
Author(s):  
Hazem El-Sherif ◽  
Mansour El-Masry ◽  
Manal F. Abou Taleb
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Anticancer Drug ◽  
Bovine Serum ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery

Box-Behnken Design Optimized TPGS Coated Bovine Serum Albumin Nanoparticles Loaded with Anastrozole

2021 ◽  
Vol 18 ◽  
Author(s):  
Ashish Kumar ◽  
Ajit Singh ◽  
S.J.S Flora ◽  
Rahul Shukla
Keyword(s):  
Particle Size ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Glycol Succinate ◽  
Burst Release ◽  
Spectroscopic Techniques ◽  
Potential Candidate ◽  
Box Behnken Design ◽  
Thermal Gelation

Purpose: In this study, a novel D-α-tocopheryl polyethylene glycol succinate (TPGS) modified bovine serum albumin (BSA) nanoparticles were developed for delivery of Anastrozole (ANZ) which is optimized by Box-Behnken design (BBD). This TPGS-ANZ-BSA NPs are evaluated for their physicochemical and drug release characteristics. Methods: TPGS-ANZ-BSA NPs were prepared by desolvation thermal gelation method andthe effects of critical process parameter (CPP)which are BSA amount, TPGS concentration and stirring speed on the critical quality attributes (CQA) such as % drug loading (%DL) and particle size were studied using BBD. TPGS-ANZ-BSA NPs were characterized using different spectroscopic techniques including UV-Visible and FTIR is used to confirm the entrapment of ANZ in BSA. DSC and PXRD revealed the amorphization of ANZ in the TPGS-ANZ-BSA NPs after freeze drying. Scanning electron microscopy (SEM) analysis was performed for the surface morphologyanalysesNPs. In vitro release studies were performed at pH 5.5 and pH 7.4 for 48h to mimic tumour microenvironment. Results: The BBD optimized batch showed 107 nm particle size with % DL of 8.5± 0.5 of TPGS-ANZ-BSA NPs. The spectroscopic and thermal characterizations revealed the successful encapsulation of ANZ inside the nanoparticles.The TPGS-ANZ-BSA NPs were found to exhibit burst release at pH 5.5 and sustained release at pH 7.4. The short-term stability of drug-loaded nanoparticles displayed no significant changes in physicochemical properties at room temperature for period of one month. Conclusion: The BBD optimized TPGS-ANZ-BSA nanoparticles showed enhanced physiochemical properties for ANZ and potential candidate for anticancer agent drugs delivery.

scholarly journals Studies on Thermal Aggregation of Bovine Serum Albumin as a Drug Carrier.

2000 ◽  
Vol 48 (4) ◽  
pp. 464-466 ◽  
Author(s):  
Chikako HONDA ◽  
Hiroko KAMIZONO ◽  
Tomomi SAMEJIMA ◽  
Kazutoyo ENDO
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Drug Carrier ◽  
Thermal Aggregation

Study of the interaction of an anticancer drug with human and bovine serum albumin: Spectroscopic approach

2006 ◽  
Vol 41 (2) ◽  
pp. 393-399 ◽  
Author(s):  
P.B. Kandagal ◽  
S. Ashoka ◽  
J. Seetharamappa ◽  
S.M.T. Shaikh ◽  
Y. Jadegoud ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Anticancer Drug ◽  
Bovine Serum

Experimental and computational investigation on the binding of anticancer drug gemcitabine with bovine serum albumin

2021 ◽  
pp. 1-14
Author(s):  
Mohd Sajid Ali ◽  
Jayaraman Muthukumaran ◽  
Monika Jain ◽  
Hamad A. Al-Lohedan ◽  
M. Abul Farah ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Anticancer Drug ◽  
Bovine Serum ◽  
Computational Investigation
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