scholarly journals Hollow nanoporous covalent triazine frameworks via acid vapor-assisted solid phase synthesis for enhanced visible light photoactivity

2016 ◽  
Vol 4 (20) ◽  
pp. 7555-7559 ◽  
Author(s):  
Wei Huang ◽  
Zi Jun Wang ◽  
Beatriz Chiyin Ma ◽  
Saman Ghasimi ◽  
Dominik Gehrig ◽  
...  
Keyword(s):  
Visible Light ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Trifluoromethanesulfonic Acid ◽  
Synthetic Method ◽  
Reaction Conditions ◽  
Acid Vapor ◽  
Phase Synthesis ◽  
Interconnected Pores

Herein, we report a novel trifluoromethanesulfonic acid vapor-assisted solid phase synthetic method to construct nanoporous covalent triazine frameworks with highly ordered hollow interconnected pores under mild reaction conditions.

scholarly journals The Pictet-Spengler Reaction Updates Its Habits

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 414 ◽  
Author(s):  
Andrea Calcaterra ◽  
Laura Mangiardi ◽  
Giuliano Delle Monache ◽  
Deborah Quaglio ◽  
Silvia Balducci ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthetic Method ◽  
Ring Closing Metathesis ◽  
Phase Synthesis ◽  
Acid Catalyzed ◽  
High Yields

The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks. In the lustro (five-year period) following its centenary birthday, the P-S reaction did not exit the stage but it came up again on limelight with new features. This review focuses on the interesting results achieved in this period (2011–2015), analyzing the versatility of this reaction. Classic P-S was reported in the total synthesis of complex alkaloids, in combination with chiral catalysts as well as for the generation of libraries of compounds in medicinal chemistry. The P-S has been used also in tandem reactions, with the sequences including ring closing metathesis, isomerization, Michael addition, and Gold- or Brønsted acid-catalyzed N-acyliminium cyclization. Moreover, the combination of P-S reaction with Ugi multicomponent reaction has been exploited for the construction of highly complex polycyclic architectures in few steps and high yields. The P-S reaction has also been successfully employed in solid-phase synthesis, affording products with different structures, including peptidomimetics, synthetic heterocycles, and natural compounds. Finally, the enzymatic version of P-S has been reported for biosynthesis, biotransformations, and bioconjugations.

Solid-phase synthesis and photoactivity of Ru-polypyridyl visible light chromophores bonded through carbon to semiconductor surfaces

2020 ◽  
Vol 49 (29) ◽  
pp. 10173-10184
Author(s):  
Mona Amiri ◽  
Octavio Martinez Perez ◽  
Riley T. Endean ◽  
Loorthuraja Rasu ◽  
Prabin Nepal ◽  
...  
Keyword(s):  
Visible Light ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Semiconductor Surfaces ◽  
Phase Synthesis

Solid-phase synthesis of monomeric and dimeric Ru-polypyridyl visible light chromophores.

scholarly journals Solid-Phase Synthesis as a Platform for the Discovery of New Ruthenium Complexes for Efficient Release of Photocaged Ligands with Visible Light

2015 ◽  
Vol 54 (4) ◽  
pp. 1901-1911 ◽  
Author(s):  
Rajgopal Sharma ◽  
Jessica D. Knoll ◽  
Nicholas Ancona ◽  
Phillip D. Martin ◽  
Claudia Turro ◽  
...  
Keyword(s):  
Visible Light ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Ruthenium Complexes ◽  
Phase Synthesis

scholarly journals Solid-Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3271
Author(s):  
Krzysztof Kaczmarek ◽  
Barbara Pacholczyk-Sienicka ◽  
Łukasz Albrecht ◽  
Janusz Zabrocki ◽  
Ronald J. Nachman
Keyword(s):  
Bioactive Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Peptide Bond ◽  
Synthetic Method ◽  
Phase Synthesis ◽  
Iminium Salt ◽  
Diaminopropanoic Acid ◽  
Imidazoline Ring ◽  
Ring Motif

A facile solid-phase synthetic method for incorporating the imidazoline ring motif, a surrogate for a trans peptide bond, into bioactive peptides is reported. The example described is the synthesis of an imidazoline peptidomimetic analog of an insect pyrokinin neuropeptide via a cyclization reaction of an iminium salt generated from the preceding amino acid and 2,4-diaminopropanoic acid (Dap).

Solid-phase synthesis of peptide Mn(I)–carbonyl bioconjugates and their CO release upon visible light activation

2021 ◽  
Author(s):  
Yi Zhou ◽  
Yonglu Chen ◽  
Chunmao He
Keyword(s):  
Visible Light ◽  
Late Stage ◽  
Chelating Agents ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Light Activation ◽  
Synthetic Route ◽  
One Pot ◽  
Phase Synthesis ◽  
Visible Light Activation

A one-pot synthetic route has been developed for the assembly of peptide Mn(I)–carbonyl bioconjugates. It allows the installation of a variety of chelating agents at late stage, and after just...

Solid phase synthesis of bioadhesive analogue peptides with trifluoromethanesulfonic acid cleavage from PAM resin

2009 ◽  
Vol 33 (5) ◽  
pp. 318-327 ◽  
Author(s):  
MICHAEL D. SWERDLOFF ◽  
SUSAN B. ANDERSON ◽  
R. DONALD SEDGWICK ◽  
MINA K. GABRIEL ◽  
RAYMOND J. BRAMBILLA ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Trifluoromethanesulfonic Acid ◽  
Phase Synthesis ◽  
Acid Cleavage
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