Solid-Phase Synthesis of Trisubstituted Benzo[f][1,2,3]triazolo[1,5-a][1,4]diazepin-6(5H)-ones and Their Sulfonyl Analogues under Mild Reaction Conditions

2015 ◽  
Vol 2015 (16) ◽  
pp. 3551-3557 ◽  
Author(s):  
Veronika Fülöpová ◽  
Petr Funk ◽  
Igor Popa ◽  
Claire McMaster ◽  
Miroslav Soural
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Reaction Conditions ◽  
Phase Synthesis

scholarly journals Hollow nanoporous covalent triazine frameworks via acid vapor-assisted solid phase synthesis for enhanced visible light photoactivity

2016 ◽  
Vol 4 (20) ◽  
pp. 7555-7559 ◽  
Author(s):  
Wei Huang ◽  
Zi Jun Wang ◽  
Beatriz Chiyin Ma ◽  
Saman Ghasimi ◽  
Dominik Gehrig ◽  
...  
Keyword(s):  
Visible Light ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Trifluoromethanesulfonic Acid ◽  
Synthetic Method ◽  
Reaction Conditions ◽  
Acid Vapor ◽  
Phase Synthesis ◽  
Interconnected Pores

Herein, we report a novel trifluoromethanesulfonic acid vapor-assisted solid phase synthetic method to construct nanoporous covalent triazine frameworks with highly ordered hollow interconnected pores under mild reaction conditions.

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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