scholarly journals pH- and ligand-induced release of loads from DNA–acrylamide hydrogel microcapsules

2017 ◽  
Vol 8 (5) ◽  
pp. 3362-3373 ◽  
Author(s):  
Wei-Ching Liao ◽  
Sivan Lilienthal ◽  
Jason S. Kahn ◽  
Marianna Riutin ◽  
Yang Sung Sohn ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Stimuli Responsive ◽  
Triggered Release

A generic method of preparing stimuli-responsive substrate-loaded hydrogel microcapsules, composed of polyacrylamide chains cross-linked by nucleic acids, has been described. The triggered release of loads from the microcapsules proceeds via either the formation of an ATP aptamer or a cocaine aptamer, or the pH-induced generation of i-motif structures.

scholarly journals Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1342 ◽  
Author(s):  
Aaron Alford ◽  
Brenna Tucker ◽  
Veronika Kozlovskaya ◽  
Jun Chen ◽  
Nirzari Gupta ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Defense Mechanisms ◽  
The Body ◽  
Stimuli Responsive ◽  
Triggered Release ◽  
Quadruplex Dna ◽  
Nucleic Acid Therapeutics ◽  
Wide Range ◽  
G Quadruplex ◽  
Hydrogel Capsules

Nucleic acid therapeutics have the potential to be the most effective disease treatment strategy due to their intrinsic precision and selectivity for coding highly specific biological processes. However, freely administered nucleic acids of any type are quickly destroyed or rendered inert by a host of defense mechanisms in the body. In this work, we address the challenge of using nucleic acids as drugs by preparing stimuli responsive poly(methacrylic acid)/poly(N-vinylpyrrolidone) (PMAA/PVPON)n multilayer hydrogel capsules loaded with ~7 kDa G-quadruplex DNA. The capsules are shown to release their DNA cargo on demand in response to both enzymatic and ultrasound (US)-triggered degradation. The unique structure adopted by the G-quadruplex is essential to its biological function and we show that the controlled release from the microcapsules preserves the basket conformation of the oligonucleotide used in our studies. We also show that the (PMAA/PVPON) multilayer hydrogel capsules can encapsulate and release ~450 kDa double stranded DNA. The encapsulation and release approaches for both oligonucleotides in multilayer hydrogel microcapsules developed here can be applied to create methodologies for new therapeutic strategies involving the controlled delivery of sensitive biomolecules. Our study provides a promising methodology for the design of effective carriers for DNA vaccines and medicines for a wide range of immunotherapies, cancer therapy and/or tissue regeneration therapies in the future.

pH-Triggered release of gemcitabine from polymer coated nanodiamonds fabricated by RAFT polymerization and copper free click chemistry

2016 ◽  
Vol 7 (40) ◽  
pp. 6220-6230 ◽  
Author(s):  
Haiwang Lai ◽  
Mingxia Lu ◽  
Hongxu Lu ◽  
Martina H. Stenzel ◽  
Pu Xiao
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Click Chemistry ◽  
Raft Polymerization ◽  
Stimuli Responsive ◽  
Triggered Release

Prodrug (gemcitabine)-based polymer coated nanodiamonds as stimuli-responsive drug delivery platforms for the treatment of pancreatic cancer.

Photo-triggered release of doxorubicin from liposomes formulated by amphiphilic phthalocyanines for combination therapy to enhance antitumor efficacy

2020 ◽  
Vol 8 (35) ◽  
pp. 8022-8036
Author(s):  
Ke Zheng ◽  
Hongyan Liu ◽  
Xinxin Liu ◽  
Libin Jiang ◽  
Linlin Li ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Antitumor Efficacy ◽  
Stimuli Responsive ◽  
Triggered Release

Multidrug combination therapy based on stimuli-responsive liposomes formulated by amphiphilic phthalocyanines has great potential for cancer treatment.

scholarly journals Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

2015 ◽  
Vol 6 (3) ◽  
pp. 1640-1644 ◽  
Author(s):  
Li-Li Tan ◽  
Haiwei Li ◽  
Yu-Chen Qiu ◽  
Dai-Xiong Chen ◽  
Xin Wang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Triggered Release ◽  
Metal Organic ◽  
Hybrid Platform ◽  
First Time

Mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered release capabilities were constructed for the first time as a new stimuli-responsive theranostic hybrid platform.

scholarly journals Liquid Crystal Coacervates Composed of Short Double Stranded DNA and Cationic Peptides

2020 ◽  
Author(s):  
Tommaso Fraccia ◽  
Tony Z. Jia
Keyword(s):  
Liquid Crystal ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Cellular Compartment ◽  
Complex Phase ◽  
Double Stranded Dna ◽  
Monovalent Salt ◽  
And Function ◽  
Multi Phase

<p>Phase separation of nucleic acids and proteins is a ubiquitous phenomenon regulating sub-cellular compartment structure and function. While complex coacervation of flexible single stranded nucleic acids is broadly investigated, coacervation of double stranded DNA (dsDNA) is less studied because of its propensity to generate solid precipitates. Here, we reverse this perspective by showing that short dsDNA and poly-L-lysine coacervates can escape precipitation while displaying a surprisingly complex phase diagram, including the full set of liquid crystal (LC) mesophases observed to date in bulk dsDNA. LC-coacervate structure was characterized upon variations in temperature and monovalent salt, DNA and peptide concentrations, which allow continuous transitions between all accessible phases. A deeper understanding of LC-coacervates can gain insights to decipher structures and phase transition mechanisms within biomolecular condensates, to design stimuli-responsive multi-phase synthetic compartments with different degrees of order and to exploit self-assembly driven cooperative prebiotic evolution of nucleic acids and peptides.</p>

scholarly journals pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2961 ◽  
Author(s):  
Rimesh Augustine ◽  
Nagendra Kalva ◽  
Ho An Kim ◽  
Yu Zhang ◽  
Il Kim
Keyword(s):  
Cellular Level ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Triggered Release ◽  
Guest Molecules ◽  
Ph Variation ◽  
Stimuli Responsive Polymers ◽  
Pharmaceutical Application ◽  
Organ Tissue ◽  
Theranostic Applications

Smart nano-carriers have attained great significance in the biomedical field due to their versatile and interesting designs with different functionalities. The initial stages of the development of nanocarriers mainly focused on the guest loading efficiency, biocompatibility of the host and the circulation time. Later the requirements of less side effects with more efficacy arose by attributing targetability and stimuli-responsive characteristics to nano-carriers along with their bio- compatibility. Researchers are utilizing many stimuli-responsive polymers for the better release of the guest molecules at the targeted sites. Among these, pH-triggered release achieves increasing importance because of the pH variation in different organ and cancer cells of acidic pH. This specific feature is utilized to release the guest molecules more precisely in the targeted site by designing polymers having specific functionality with the pH dependent morphology change characteristics. In this review, we mainly concert on the pH-responsive polypeptides and some interesting nano-carrier designs for the effective theranostic applications. Also, emphasis is made on pharmaceutical application of the different nano-carriers with respect to the organ, tissue and cellular level pH environment.

Light-responsive arylazopyrazole-based hydrogels: their applications as shape-memory materials, self-healing matrices and controlled drug release systems

2019 ◽  
Vol 10 (30) ◽  
pp. 4106-4115 ◽  
Author(s):  
Gilad Davidson-Rozenfeld ◽  
Lucas Stricker ◽  
Julian Simke ◽  
Michael Fadeev ◽  
Margarita Vázquez-González ◽  
...  
Keyword(s):  
Drug Release ◽  
Nucleic Acids ◽  
Shape Memory ◽  
Carboxymethyl Cellulose ◽  
Controlled Drug Release ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Shape Memory Materials ◽  
Responsive Hydrogels

Carboxymethyl cellulose functionalized with nucleic acids, β-cyclodextrin and arylazopyrazole photoisomerizable units self-assembles into stimuli-responsive hydrogels.

scholarly journals Stimuli responsive charge-switchable lipids: Capture and release of nucleic acids

2016 ◽  
Vol 196 ◽  
pp. 52-60 ◽  
Author(s):  
Joseph S. Hersey ◽  
Caroline M. LaManna ◽  
Hrvoje Lusic ◽  
Mark W. Grinstaff
Keyword(s):  
Nucleic Acids ◽  
Stimuli Responsive ◽  
Capture And Release

Stimuli-Responsive Lipidic Cubic Phase: Triggered Release and Sequestration of Guest Molecules

2014 ◽  
Vol 21 (5) ◽  
pp. 1873-1877 ◽  
Author(s):  
Nelli Rahanyan-Kägi ◽  
Simone Aleandri ◽  
Chiara Speziale ◽  
Raffaele Mezzenga ◽  
Ehud M. Landau
Keyword(s):  
Cubic Phase ◽  
Stimuli Responsive ◽  
Triggered Release ◽  
Guest Molecules ◽  
Lipidic Cubic Phase

scholarly journals Dynamic regulation of DNA nanostructures by noncanonical nucleic acids

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Shiliang He ◽  
Zhilei Ge ◽  
Xiaolei Zuo ◽  
Chunhai Fan ◽  
Xiuhai Mao
Keyword(s):  
Nucleic Acids ◽  
Spatial Organization ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Structural Morphology ◽  
Dynamic Regulation ◽  
Hierarchical Assembly ◽  
Dna Triplexes ◽  
Potential Applications ◽  
External Stimuli

AbstractDNA nanostructures are among the most fascinating self-assembled nanostructures in diverse areas of science and technology, because of their nanoscale precision in biomolecule and nanoparticle organization. The implementation of dynamic and spatial regulation in structural morphology and hierarchical assembly upon specific external stimuli will greatly expand their applications in biocomputation, clinical diagnosis, and cancer therapy. Recently, noncanonical nucleic acids, particularly DNA triplexes, i-motifs, and G-quadruplexes, have become powerful tools for biosensing and mechanical switching. Developments in incorporating stimuli-responsive noncanonical nucleic acids into DNA nanostructures provide a promising approach to regulating the spatial organization and hierarchical assembly of DNA nanostructures. In this review, we briefly introduce recent progress in constructing DNA nanostructures with dynamic regulation of the structural transformation and programmable assembly pathways at the nanometer scale by noncanonical nucleic acids and discuss their potential applications and challenges.

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