scholarly journals Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

2017 ◽  
Vol 8 (4) ◽  
pp. 2782-2789 ◽  
Author(s):  
Jie Liu ◽  
Chao Chen ◽  
Shenglu Ji ◽  
Qian Liu ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Fluorescent Nanoparticles ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Long Wavelength ◽  
Image Guided ◽  
Fluorescent Molecules

Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

2019 ◽  
Vol 62 (11) ◽  
pp. 1472-1480 ◽  
Author(s):  
Xiaoyan Zhang ◽  
Cong Li ◽  
Wenyi Liu ◽  
Hanlin Ou ◽  
Dan Ding
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Aggregation Induced Emission ◽  
Image Guided

Efficient near-infrared photosensitizer with aggregation-induced emission characteristics for mitochondria-targeted and image-guided photodynamic cancer therapy

2020 ◽  
Vol 4 (7) ◽  
pp. 2064-2071 ◽  
Author(s):  
Hanxiao Yang ◽  
Jiabao Zhuang ◽  
Nan Li ◽  
Yue Li ◽  
Shiyu Zhu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Highly Efficient ◽  
Photodynamic Cancer Therapy

A highly efficient near-infrared photosensitizer with aggregation-induced emission characteristics was developed for mitochondria-targeted and image-guided photodynamic cancer therapy.

High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. 1110-1114 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Shidang Xu ◽  
Shenglu Ji ◽  
Fang Hu ◽  
...  
Keyword(s):  
High Performance ◽  
Near Infrared ◽  
Anticancer Therapy ◽  
Infrared Emission ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Near Infrared Emission

A series of D–A′–π–A type photosensitizers were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously, and have been successfully used for image-guided photodynamic anticancer therapy.

Use of in vivo near-infrared laser confocal endomicroscopy with indocyanine green to detect the boundary of infiltrative tumor

2011 ◽  
Vol 115 (6) ◽  
pp. 1131-1138 ◽  
Author(s):  
Nikolay L. Martirosyan ◽  
Daniel D. Cavalcanti ◽  
Jennifer M. Eschbacher ◽  
Peter M. Delaney ◽  
Adrienne C. Scheck ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Tumor Cells ◽  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Normal Brain ◽  
Tumor Margins ◽  
Confocal Endomicroscopy ◽  
Infiltrative Tumor

Object Infiltrative tumor resection is based on regional (macroscopic) imaging identification of tumorous tissue and the attempt to delineate invasive tumor margins in macroscopically normal-appearing tissue, while preserving normal brain tissue. The authors tested miniaturized confocal fiberoptic endomicroscopy by using a near-infrared (NIR) imaging system with indocyanine green (ICG) as an in vivo tool to identify infiltrating glioblastoma cells and tumor margins. Methods Thirty mice underwent craniectomy and imaging in vivo 14 days after implantation with GL261-luc cells. A 0.4 mg/kg injection of ICG was administered intravenously. The NIR images of normal brain, obvious tumor, and peritumoral zones were collected using the handheld confocal endomicroscope probe. Histological samples were acquired from matching imaged areas for correlation of tissue images. Results In vivo NIR wavelength confocal endomicroscopy with ICG detects fluorescence of tumor cells. The NIR and ICG macroscopic imaging performed using a surgical microscope correlated generally to tumor and peritumor regions, but NIR confocal endomicroscopy performed using ICG revealed individual tumor cells and satellites within peritumoral tissue; a definitive tumor border; and striking fluorescent microvascular, cellular, and subcellular structures (for example, mitoses, nuclei) in various tumor regions correlating with standard clinical histological features and known tissue architecture. Conclusions Macroscopic fluorescence was effective for gross tumor detection, but NIR confocal endomicroscopy performed using ICG enhanced sensitivity of tumor detection, providing real-time true microscopic histological information precisely related to the site of imaging. This first-time use of such NIR technology to detect cancer suggests that combined macroscopic and microscopic in vivo ICG imaging could allow interactive identification of microscopic tumor cell infiltration into the brain, substantially improving intraoperative decisions.

Sign in / Sign up

Export Citation Format

Share Document