scholarly journals Controlling amphiphilic copolymer self-assembly morphologies based on macrocycle/anion recognition and nucleotide-induced payload release

2016 ◽  
Vol 7 (9) ◽  
pp. 6006-6014 ◽  
Author(s):  
Xiaofan Ji ◽  
Hu Wang ◽  
Yang Li ◽  
Danyu Xia ◽  
Hao Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Anion Recognition ◽  
Amphiphilic Copolymer ◽  
Anion Binding

We create polymeric self-assembly morphologies by exploiting the anion binding features of the so-called ‘Texas-sized’ molecular box.

scholarly journals The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Benjamin C McIlwain ◽  
Roja Gundepudi ◽  
B Ben Koff ◽  
Randy B Stockbridge
Keyword(s):  
Binding Sites ◽  
Anion Recognition ◽  
Anion Binding ◽  
Structural Studies ◽  
Planar Bilayer ◽  
X Ray ◽  
X Ray Crystallography ◽  
Molecular Determinants ◽  
Cytoplasmic Accumulation ◽  
Oriented System

Fluc family fluoride channels protect microbes against ambient environmental fluoride by undermining the cytoplasmic accumulation of this toxic halide. These proteins are structurally idiosyncratic, and thus the permeation pathway and mechanism have no analogy in other known ion channels. Although fluoride binding sites were identified in previous structural studies, it was not evident how these ions access aqueous solution, and the molecular determinants of anion recognition and selectivity have not been elucidated. Using x-ray crystallography, planar bilayer electrophysiology and liposome-based assays, we identify additional binding sites along the permeation pathway. We use this information to develop an oriented system for planar lipid bilayer electrophysiology and observe anion block at one of these sites, revealing insights into the mechanism of anion recognition. We propose a permeation mechanism involving alternating occupancy of anion binding sites that are fully assembled only as the substrate approaches.

scholarly journals Measuring anion binding at biomembrane interfaces

2021 ◽  
Author(s):  
Xin Wu ◽  
Patrick Wang ◽  
William Lewis ◽  
Yun-Bao Jiang ◽  
Philip Alan Gale
Keyword(s):  
Lipid Bilayers ◽  
Common Knowledge ◽  
Anion Recognition ◽  
Chloride Ions ◽  
Transport Processes ◽  
Anion Binding ◽  
Dihydrogen Phosphate ◽  
Materials Chemistry ◽  
Synthetic Receptor ◽  
Chemistry Research

Understanding non-covalent molecular recognition events at biomembrane interfaces is important in biological, medicinal, and materials chemistry research.1 Despite the crucial regulatory roles of anion binding/transport processes at biomembranes, no information is available regarding how strongly anions can bind to naturally occurring or synthetic receptors in lipid bilayer environments compared to their well-established behaviour in solutions.2 To bridge this knowledge gap, we synthesised a flat macrocycle that possesses a record aqueous SO42– affinity among neutral receptors and exploited its unique fluorescence response at interfaces. We show that the determinants of anion binding are extraordinarily different in organic solvents and in lipid bilayers. The high charge density of dihydrogen phosphate and chloride ions prevails in DMSO, however in lipids they fail to bind the macrocycle. Perchlorate and iodide hardly bind in DMSO but show significant affinities for the macrocycle in lipids. Our results demonstrate a surprisingly great advantage of large, charge-diffuse anions to bind to a lipid-embedded synthetic receptor mainly attributed to their higher polarisabilities and deeper penetration into the bilayer, beyond the common knowledge of dehydration energy-governed selectivity. The elucidation of these principles enhances our understanding of biological anion recognition functions in membranes and guides the design of ionophores and molecular machines operating at biomembrane interfaces.

scholarly journals Amphiphilic copolymer self-assembly of magnetic nanoparticles for construction of magnetically responsive photonic crystals based on steric hindrance

RSC Advances ◽  
2019 ◽  
Vol 9 (70) ◽  
pp. 41280-41286
Author(s):  
Meng Shang ◽  
Xinjiong Ni ◽  
Jiasheng Xu ◽  
Yuhua Cao
Keyword(s):  
Magnetic Nanoparticles ◽  
Photonic Crystals ◽  
Steric Hindrance ◽  
Self Assembly ◽  
Amphiphilic Copolymer ◽  
One Step

One-step self-assembly of magnetic nanoparticles with amphiphilic copolymer for construction of magnetically responsive photonic crystals based on steric hindrance.

A new tetraarylcyclopentadienone based low molecular weight gelator: synthesis, self-assembly properties and anion recognition

2012 ◽  
Vol 36 (7) ◽  
pp. 1469 ◽  
Author(s):  
Mattia Boiani ◽  
Andrea Baschieri ◽  
Cristiana Cesari ◽  
Rita Mazzoni ◽  
Stefano Stagni ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Anion Recognition ◽  
Low Molecular Weight ◽  
Low Molecular Weight Gelator

scholarly journals Synthesis and Self-Assembly of Alternating Amphiphilic Copolymer with Azobenzene Pendants

2019 ◽  
Vol 39 (10) ◽  
pp. 2952
Author(s):  
Jiacheng Wu, ◽  
Zhenghui Liu, ◽  
Yuan Yao, ◽  
Shaoliang Lin,
Keyword(s):  
Self Assembly ◽  
Amphiphilic Copolymer

Acetals moiety contained pH-sensitive amphiphilic copolymer self-assembly used for drug carrier

Polymer ◽  
2010 ◽  
Vol 51 (8) ◽  
pp. 1709-1715 ◽  
Author(s):  
Jushan Lu ◽  
Najun Li ◽  
Qingfeng Xu ◽  
Jianfeng Ge ◽  
Jianmei Lu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer
Sign in / Sign up

Export Citation Format

Share Document