scholarly journals Novel multifunctional dental bonding agent for class-V restorations to inhibit periodontal biofilms

RSC Advances ◽  
2017 ◽  
Vol 7 (46) ◽  
pp. 29004-29014 ◽  
Author(s):  
Lin Wang ◽  
Chunyan Li ◽  
Michael D. Weir ◽  
Ke Zhang ◽  
Yanmin Zhou ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Bonding Agent ◽  
Ion Release ◽  
Class V ◽  
Dental Bonding ◽  
Phosphate Ion

We recently developed a dental bonding agent to bond restorations to teeth using nanoparticles of amorphous calcium phosphate (NACP) for remineralization with rechargeable calcium and phosphate ion release.

scholarly journals Antibacterial activity and ion release of bonding agent containing amorphous calcium phosphate nanoparticles

2014 ◽  
Vol 30 (8) ◽  
pp. 891-901 ◽  
Author(s):  
Chen Chen ◽  
Michael D. Weir ◽  
Lei Cheng ◽  
Nancy J. Lin ◽  
Sheng Lin-Gibson ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Bonding Agent ◽  
Ion Release ◽  
Calcium Phosphate Nanoparticles

scholarly journals Ion release and recharge from a fissure sealant containing amorphous calcium phosphate

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241272
Author(s):  
Mahtab Memarpour ◽  
Neda Afzali Baghdadabadi ◽  
Azade Rafiee ◽  
Mehrdad Vossoughi
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Calcium Ion ◽  
Ion Release ◽  
Three Solutions ◽  
Fissure Sealant ◽  
Phosphate Ion ◽  
Phosphate Ions ◽  
Release Capacity ◽  
Casein Phosphopeptide

To assess- the release of calcium and phosphate ions from a fissure sealant containing amorphous calcium phosphate (ACP), and to determine the re-release capacity of these ions when charged with a solution containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). Nine blocks of ACP resin-based sealant were prepared and immersed in three solutions at different pH (4.0, 5.5, 7.0), and calcium and phosphate ion release was measured with ion chromatography at 1, 3, 5, 7, 14, 21 and 28 days after immersion. Sixty days after immersion, each block was charged with CPP-ACP solution in three 7-day cycles to investigate the re-release of these ions, which was measured on days 1, 3, and 7. No difference was observed in initial calcium ion release at pH 4.0 and pH 5.5. At both values, ion release was significantly higher than at pH 7.0 (p<0.001). Initial phosphate release was significantly different among the three pH values (p<0.001). After re-charging the specimens, calcium ion re-release was greater than phosphate ion release. Initial ion release from ACP resin-based sealant was greatest at the lowest pH. Ion release decreased with time. As the number of recharge cycles increased, ion re-release also improved. Phosphate ion re-release required more recharge cycles than calcium ion re-release.

Amorphous Calcium Phosphate Based Polymeric Composites: Effects of Polymer Composition and Filler's Particle Size on Composite Properties

2005 ◽  
Vol 284-286 ◽  
pp. 737-740 ◽  
Author(s):  
Drago Skrtic ◽  
S.Y. Lee ◽  
Joseph M. Antonucci ◽  
D.W. Liu
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Physicochemical Properties ◽  
Amorphous Calcium Phosphate ◽  
Fine Tuning ◽  
Polymer Composition ◽  
Ion Release ◽  
The Matrix ◽  
Carboxylic Groups ◽  
Composite Properties

This study explores how a) the resin grafting potential for amorphous calcium phosphate (ACP) and b) particle size of ACP affects physicochemical properties of composites. Copolymers and composites were evaluated for biaxial flexure strength (BFS), degree of vinyl conversion (DC), mineral ion release and water sorption (WS). Milled ACP composites were superior to unmilled ACP composites and exhibited 62 % and 77 % higher BFS values (dry and wet state, respectively). The average DC of copolymers 24 h after curing was 80 %. DC of composites decreased 10.3 % for unmilled Zr-ACP and 4.6 % for milled Zr-ACP when compared to the corresponding copolymers. The WS increased as follows: copolymers < milled Zr-ACP composites < unmilled Zr-ACP composites. The levels of Ca and PO4 released from both types of composites increased with the increasing EBPADMA/TEGDMA ratio in the matrix. They were significantly above the minimum necessary for the redeposition of HAP to occur. No significant consumption of released calcium by the carboxylic groups of methacryloxyethyl phtahalate (MEP) occurred at a mass fraction of 2.6 % of MEP in the resin. Improvements in ACP composite’s physicochemical properties are achieved by fine tuning of the resin and improved ACP’s dispersion within the polymer matrix after ball-milling.

scholarly journals Tuning Nano-Amorphous Calcium Phosphate Content in Novel Rechargeable Antibacterial Dental Sealant

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1544 ◽  
Author(s):  
Maria Ibrahim ◽  
Faisal AlQarni ◽  
Yousif Al-Dulaijan ◽  
Michael Weir ◽  
Thomas Oates ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Flexural Strength ◽  
Amorphous Calcium Phosphate ◽  
Mechanical Performance ◽  
Flexural Modulus ◽  
Dental Materials ◽  
Ion Release ◽  
Dental Sealants ◽  
Mass Fractions ◽  
The Impact

Dental sealants with antibacterial and remineralizing properties are promising for caries prevention among children and adolescents. The application of nanotechnology and polymer development have enabled nanoparticles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM) to emerge as anti-caries strategies via resin-based dental materials. Our objectives in this study were to (1) incorporate different mass fractions of NACP into a parental rechargeable and antibacterial sealant; (2) investigate the effects on mechanical performance, and (3) assess how the variations in NACP concentration would affect the calcium (Ca) and phosphate (PO4) ion release and re-chargeability over time. NACP were synthesized using a spray-drying technique and incorporated at mass fractions of 0, 10, 20 and 30%. Flexural strength, flexural modulus, and flowability were assessed for mechanical and physical performance. Ca and PO4 ion release were measured over 70 days, and three ion recharging cycles were performed for re-chargeability. The impact of the loading percentage of NACP upon the sealant’s performance was evaluated, and the optimized formulation was eventually selected. The experimental sealant at 20% NACP had flexural strength and flexural modulus of 79.5 ± 8.4 MPa and 4.2 ± 0.4 GPa, respectively, while the flexural strength and flexural modulus of a commercial sealant control were 70.7 ± 5.5 MPa (p > 0.05) and 3.3 ± 0.5 GPa (p < 0.05), respectively. A significant reduction in flow was observed in the experimental sealant at 30% NACP (p < 0.05). Increasing the NACP mass fraction increased the ion release. The sealant formulation with NACP at 20% displayed desirable mechanical performance and ideal flow and handling properties, and also showed high levels of long-term Ca and PO4 ion release and excellent recharge capabilities. The findings provide fundamental data for the development of a new generation of antibacterial and rechargeable Ca and PO4 dental sealants to promote remineralization and inhibit caries.

Effect of glass fillers on ion release from composites containing amorphous calcium phosphate

2013 ◽  
Vol 29 ◽  
pp. e35-e36
Author(s):  
M.C. Rodrigues ◽  
M.D. Chiari ◽  
A. Simões ◽  
D.N. Souza ◽  
R.R. Braga
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Ion Release ◽  
Glass Fillers

scholarly journals THE EFFECT OF CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE-PROPOLIS CHEWING GUM ON CALCIUM AND PHOSPHATE ION LEVELS IN CARIES-FREE SUBJECT’S SALIVA AND STREPTOCOCCUS MUTANS BIOFILM FORMATION

2017 ◽  
Vol 10 (17) ◽  
pp. 174
Author(s):  
Sri Angky Soekanto ◽  
Gadiacanaparimita Ghrena Duhita ◽  
Endang Winiati Bachtiar ◽  
Muhamad Sahlan
Keyword(s):  
Calcium Phosphate ◽  
Streptococcus Mutans ◽  
Calcium Ions ◽  
Amorphous Calcium Phosphate ◽  
Chewing Gum ◽  
Phosphate Ion ◽  
Phosphate Ions ◽  
Casein Phosphopeptide ◽  
Mass Formation

 Objective: The aim of this study is to analyze the amount of calcium and phosphate ion released by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), which supports the remineralization and the effectiveness of propolis wax in suppressing the mass formation of Streptococcus mutans biofilm on caries-free subjects and to observe if these two active components are effective when combined into one substance and placed inside sugar-free chewing gum.Methods: Twenty-five samples of caries-free saliva before and after the mastication simulation (five concentrations of chewing gum) in vitro were observed to check for release of calcium and phosphate ions along with a biofilm assay. The release of calcium ions was detected using AAS, the release of phosphate ions was detected using spectrophotometry ultraviolet-visible, and the biofilm assay was detected using a crystal violet 96-well plate ELISA and was evaluated with an ELISA reader.Result: Chewing gum with a concentration of 0% prop + 5% CPP-ACP showed the highest release level of calcium ions (p<0.05) and phosphate ions (p>0.05) and is significant in suppressing the mass formation of the S. mutans biofilm (p<0.05).Conclusions: Mastication simulation of CPP-ACP-Propolis chewing gum can increase calcium and phosphate ion levels in caries-free saliva and decrease S. mutans biofilm mass formation; this can support remineralization and becomes a dental caries prevention alternative.

scholarly journals Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia

2021 ◽  
pp. 1-10
Author(s):  
Ahmed Sleibi ◽  
Anwar R. Tappuni ◽  
Aylin Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Primary Root ◽  
Severity Index ◽  
Salivary Flow ◽  
Root Caries ◽  
Carious Lesions ◽  
Group 2 ◽  
Casein Phosphopeptide ◽  
Group 1

Different formulas of topical fluoride have been used to manage root carious lesions. This clinical trial aimed to investigate the efficacy of a dental varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride compared with fluoride alone in reversing/arresting root caries in xerostomic patients over 1 year. A total of 80 patients (age range 45–92 years) with primary root caries (<i>n</i> = 184 root carious lesions) and unstimulated salivary flow rate of &#x3c;0.2 mL/min were randomly allocated to receive either dental varnish containing CPP-ACP and 5% fluoride (group 1: MI varnish; GC, Japan) (<i>n</i> = 41, 83 lesions), or dental varnish with 5% fluoride alone (group 2: NUPRO White; Dentsply, USA) (<i>n</i> = 39, 101 lesions). Clinical assessments with Severity Index (SI) for root caries, DIAGNOdent measurements, and varnish application were carried out at baseline, 3, 6, and 12 months. Standard oral hygiene instructions with 1,450 ppm fluoride toothpastes were provided for both groups. After 3 months, 63.9% (<i>n</i> = 46) of root caries in group 1 became hard (SI: 0) compared with 39.3% (<i>n</i> = 35) in group 2 (<i>p</i> &#x3c; 0.01). After 6 and 12 months, the differences in SI were insignificant (group 1, <i>n</i> = 60, 83.3%) (group 2, <i>n</i> = 66, 74.2%) (<i>p</i> = 0.36), and (group 1, <i>n</i> = 60, 89.6%) (group 2, <i>n</i> = 67, 81.7%, <i>n</i> = 1 soft, 1.2%) (<i>p</i> = 0.29), respectively. In both groups, noncavitated leathery lesions were more likely to become hard when compared to the cavitated root caries. A significant decrease in plaque index, surface roughness, lesion dimension, and DIAGNOdent readings with a significant increase in lesion distance from the gingival margin was reported in both groups (<i>p</i> &#x3c; 0.05). This study has provided evidence that fluoride dental varnish either with or without calcium and phosphate has the potential to arrest/reverse root caries, especially noncavitated lesions for patients with xerostomia.

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