scholarly journals Biodegradable, pH-responsive chitosan aerogels for biomedical applications

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32960-32965 ◽  
Author(s):  
J. Radwan-Pragłowska ◽  
M. Piątkowski ◽  
Ł. Janus ◽  
D. Bogdał ◽  
D. Matysek
Keyword(s):  
Biomedical Applications ◽  
Ph Responsive ◽  
Step Process ◽  
Mw Irradiation

Biodegradable chitosan aerogels with advanced properties for biomedical applications are obtained in a two-step process using biotolerant chemicals, MW irradiation and lyophilisation.

Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy

2016 ◽  
Vol 4 (29) ◽  
pp. 5046-5058 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Yongli Wang ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Anticancer Therapy ◽  
Effective Strategy ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Delivery Platform

We introduce a simple and effective strategy to design a promising drug delivery platform for improving the biomedical applications of smart nanodiamond carriers.

Fine-tuning the pH response of polymersomes for mimicking and controlling the cell membrane functionality

2017 ◽  
Vol 8 (19) ◽  
pp. 2904-2908 ◽  
Author(s):  
Hannes Gumz ◽  
Thu Hang Lai ◽  
Brigitte Voit ◽  
Dietmar Appelhans
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Biomedical Applications ◽  
Fine Tuning ◽  
Ph Responsive ◽  
Ph Response

To expand the biomedical applications of pH responsive polymersomes a concept is presented for precisely adjusting the pH triggered transition of the membrane permeability.

scholarly journals Engineering pH responsive fibronectin domains for biomedical applications

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Pete Heinzelman ◽  
John Krais ◽  
Eliza Ruben ◽  
Robert Pantazes
Keyword(s):  
Biomedical Applications ◽  
Ph Responsive ◽  
Fibronectin Domains

Biomedical Applications of pH-Responsive Amphiphilic Polymer Nanoassemblies

2020 ◽  
Vol 3 (3) ◽  
pp. 2104-2117 ◽  
Author(s):  
Shivshankar R. Mane ◽  
Ashlin Sathyan ◽  
Raja Shunmugam
Keyword(s):  
Biomedical Applications ◽  
Amphiphilic Polymer ◽  
Ph Responsive

scholarly journals Stimuli-Responsive Micelles with Detachable Poly(2-ethyl-2-oxazoline) Shell Based on Amphiphilic Polyurethane for Improved Intracellular Delivery of Doxorubicin

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2642
Author(s):  
Kang Xu ◽  
Xiaojun Liu ◽  
Leran Bu ◽  
Hena Zhang ◽  
Caihong Zhu ◽  
...  
Keyword(s):  
Disulfide Bonds ◽  
Biomedical Applications ◽  
Fluorescent Microscopy ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
C6 Cells ◽  
Stimuli Responsive ◽  
Trimethylene Carbonate ◽  
Ph Responsive ◽  
Drug Release Profile

Polyurethanes (PUs) have various biomedical applications including controlled drug delivery. However, the incompletely release of drug at tumor sites limits the efficiency of these drug loaded polyurethane micelles. Here we report a novel polymer poly(2-ethyl-2-oxazoline)-SS-polyurethane-SS-poly(2-ethyl-2-oxazoline) triblock polyurethane (PEtOz-PU(PTMCSS)-PEtOz). The hydrophilic pH-responsive poly(2-ethyl-2-oxazoline) was used as an end-block to introduce pH responsiveness, and the hydrophobic PU middle-block was easily synthesized by the reaction of poly (trimethylene carbonate) diol containing disulfide bonds (PTMC-SS-PTMC diol) and bis (2-isocyanatoethyl) disulfide (CDI). PEtOz-PU(PTMCSS)-PEtOz could self-assemble to form micelles (176 nm). The drug release profile of PEtOz-PU(PTMCSS)-PEtOz micelles loaded with Doxorubicin (DOX) was studied in the presence of acetate buffer (10 mM, pH 5.0) and 10 mM dithiothreitol (DTT). The results showed that under this environment, DOX-loaded polyurethane micelles could release DOX faster and more thoroughly, about 97% of the DOX was released from the DOX-loaded PEtOz-PU(PTMCSS)-PEtOz micelle. In addition, fluorescent microscopy and cell viability assays validated that the DOX-loaded polyurethane micelle strongly inhibits the growth of C6 cells, suggesting their potential as a new nanomedicine against cancer.

Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots

2022 ◽  
Vol 43 (01) ◽  
pp. 137-151
Author(s):  
Song-jie HE ◽  
◽  
Qing-mei ZHANG ◽  
Lu-peng ZHANG ◽  
Xiu-juan DU ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Biomedical Applications ◽  
Ph Responsive

Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications

2016 ◽  
Vol 26 (34) ◽  
pp. 6158-6169 ◽  
Author(s):  
Feng Kong ◽  
Hongbo Zhang ◽  
Xu Zhang ◽  
Dongfei Liu ◽  
Dong Chen ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Biomedical Applications ◽  
Ph Responsive ◽  
Hybrid Platform
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