scholarly journals Self-assembled PEG–carboxymethylcellulose nanoparticles/α-cyclodextrin hydrogels for injectable and thermosensitive drug delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 2905-2912 ◽  
Author(s):  
Lin Dai ◽  
Rui Liu ◽  
Li-Qiu Hu ◽  
Jun-Hui Wang ◽  
Chuan-Ling Si
Keyword(s):  
Drug Delivery ◽  
Inclusion Complex ◽  
Betulinic Acid ◽  
Aqueous Media ◽  
Self Assembled ◽  
First Time

Novel cellulose hydrogels based on the inclusion complex between α-cyclodextrin and binary-drug loaded nanoparticles (carboxymethylcellulose–betulinic acid/hydroxycamptothecine nanoparticles) were prepared in aqueous media for the first time.

scholarly journals Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 50
Author(s):  
Aila Jimenez-Ruiz ◽  
Rafael Prado-Gotor ◽  
José G. Fernández-Bolaños ◽  
Alejandro González-Benjumea ◽  
José María Carnerero
Keyword(s):  
Marked Decrease ◽  
Aqueous Media ◽  
Nanoparticle Synthesis ◽  
Reaction Medium ◽  
Concentrated Solutions ◽  
Protection Mechanisms ◽  
Self Assembled ◽  
Concentration Threshold ◽  
Gold Nanoparticle Synthesis ◽  
First Time

Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) concentration in the reaction medium was found to greatly influence the outcome and stability of the resulting nanocolloid, with a marked decrease in particle size being found for the more concentrated oleuropein solutions. The protection mechanisms involved in the stabilized nanosystems were analyzed. Oleuropein self-assembled structures were found to be formed at a concentration threshold of [OLE] > 5 × 10−5 M, and observed through the use of CryoSEM imaging. Those structures were responsible for both the increased stability and the decrease in size observed at the more concentrated solutions.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Green Synthesis and Spectroscopic Studies of Ag-rGO Nanocomposites for Highly Selective Mercury (II) Sensing

2018 ◽  
Vol 9 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Shubhangi J. Mane-Gavade ◽  
Sandip R. Sabale ◽  
Xiao-Ying Yu ◽  
Gurunath H. Nikam ◽  
Bhaskar V. Tamhankar
Keyword(s):  
Green Synthesis ◽  
Color Change ◽  
Limit Of Detection ◽  
Aqueous Media ◽  
Suitable Condition ◽  
Cost Effective ◽  
Spectroscopic Studies ◽  
Calibration Plot ◽  
First Time

Introduction: Herein we report the green synthesis and characterization of silverreduced graphene oxide nanocomposites (Ag-rGO) using Acacia nilotica gum for the first time. Experimental: We demonstrate the Hg2+ ions sensing ability of the Ag-rGO nanocomposites form aqueous medium. The developed colorimetric sensor method is simple, fast and selective for the detection of Hg2+ ions in aqueous media in presence of other associated ions. A significant color change was noticed with naked eye upon Hg2+ addition. The color change was not observed for cations including Sr2+, Ni2+, Cd2+, Pb2+, Mg2+, Ca2+, Fe2+, Ba2+ and Mn2+indicating that only Hg2+ shows a strong interaction with Ag-rGO nanocomposites. Under the most suitable condition, the calibration plot (A0-A) against concentration of Hg2+ was linear in the range of 0.1-1.0 ppm with a correlation coefficient (R2) value 0.9998. Results & Conclusion The concentration of Hg2+ was quantitatively determined with the Limit of Detection (LOD) of 0.85 ppm. Also, this method shows excellent selectivity towards Hg2+ over nine other cations tested. Moreover, the method offers a new cost effective, rapid and simple approach for the detection of Hg2+ in water samples.

scholarly journals Synthesis of novel adsorbent based on tetrasulfide-functionalized fibrous silica KCC-1 for removal of Hg(II) cations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Azam Marjani ◽  
Reza Khan Mohammadi
Keyword(s):  
Effective Interaction ◽  
Sol Gel ◽  
Aqueous Media ◽  
Synthesis Method ◽  
Mercury Ions ◽  
Toxic Heavy Metals ◽  
Uptake Capacity ◽  
Hydrothermal Preparation ◽  
Ultrasonic Assisted ◽  
First Time

AbstractHg(II) has been identified to be one of the extremely toxic heavy metals because of its hazardous effects and this fact that it is even more hazardous to animals than other pollutants such as Ag, Au, Cd, Ni, Pb, Co, Cu, and Zn. Accordingly, for the first time, tetrasulfide-functionalized fibrous silica KCC-1 (TS-KCC-1) spheres were synthesized by a facile, conventional ultrasonic-assisted, sol–gel-hydrothermal preparation approach to adsorb Hg(II) from aqueous solution. Tetrasulfide groups (–S–S–S–S–) were chosen as binding sites due to the strong and effective interaction of mercury ions (Hg(II)) with sulfur atoms. Hg(II) uptake onto TS-KCC-1 in a batch system has been carried out. Isotherm and kinetic results showed a very agreed agreement with Langmuir and pseudo-first-order models, respectively, with a Langmuir maximum uptake capacity of 132.55 mg g–1 (volume of the solution = 20.0 mL; adsorbent dose = 5.0 mg; pH = 5.0; temperature: 198 K; contact time = 40 min; shaking speed = 180 rpm). TS-KCC-1was shown to be a promising functional nanoporous material for the uptake of Hg(II) cations from aqueous media. To the best of our knowledge, there has been no report on the uptake of toxic Hg(II) cations by tetrasulfide-functionalized KCC-1 prepared by a conventional ultrasonic-assisted sol–gel-hydrothermal synthesis method.

scholarly journals Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Leela Goel ◽  
Huaiyu Wu ◽  
Bohua Zhang ◽  
Jinwook Kim ◽  
Paul A. Dayton ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Negative Pressure ◽  
Boiling Point ◽  
Clot Lysis ◽  
Control Group ◽  
Peak Negative Pressure ◽  
Blood Clots ◽  
Tissue Plasminogen ◽  
First Time

AbstractOne major challenge in current microbubble (MB) and tissue plasminogen activator (tPA)-mediated sonothrombolysis techniques is effectively treating retracted blood clots, owing to the high density and low porosity of retracted clots. Nanodroplets (NDs) have the potential to enhance retracted clot lysis owing to their small size and ability to penetrate into retracted clots to enhance drug delivery. For the first time, we demonstrate that a sub-megahertz, forward-viewing intravascular (FVI) transducer can be used for ND-mediated sonothrombolysis, in vitro. In this study, we determined the minimum peak negative pressure to induce cavitation with low-boiling point phase change nanodroplets and clot lysis. We then compared nanodroplet mediated sonothrombolysis to MB and tPA mediate techniques. The clot lysis as a percent mass decrease in retracted clots was 9 ± 8%, 9 ± 5%, 16 ± 5%, 14 ± 9%, 17 ± 9%, 30 ± 8%, and 40 ± 9% for the control group, tPA alone, tPA + US, MB + US, MB + tPA + US, ND + US, and ND + tPA + US groups, respectively. In retracted blood clots, combined ND- and tPA-mediated sonothrombolysis was able to significantly enhance retracted clot lysis compared with traditional MB and tPA-mediated sonothrombolysis techniques. Combined nanodroplet with tPA-mediated sonothrombolysis may provide a feasible strategy for safely treating retracted clots.

scholarly journals Exploring the utility of hybrid siloxane-phosphocholine (SiPC) liposomes as drug delivery vehicles

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 13014-13023
Author(s):  
Mark B. Frampton ◽  
Andrea Blais ◽  
Zachary Raczywolski ◽  
Alan Castle ◽  
Paul M. Zelisko
Keyword(s):  
Drug Delivery ◽  
Aqueous Media ◽  
Unilamellar Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Hybrid siloxane-phosphocholines (SiPCs) are a unique class of lipids that spontaneously form unilamellar vesicles (ULVs) that are ∼100 nm in diameter upon exposure to aqueous media without the need for extrusion and can be used as delivery vehicles.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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