scholarly journals Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: drug delivery and cytotoxicity assays

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111060-111069 ◽  
Author(s):  
Laura Español ◽  
Ane Larrea ◽  
Vanesa Andreu ◽  
Gracia Mendoza ◽  
Manuel Arruebo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plga Nanoparticles ◽  
Single Step ◽  
Step Method ◽  
Drug Encapsulation ◽  
Hydrophilic Drugs ◽  
Biodegradable Nanoparticles ◽  
Cytotoxicity Assays ◽  
Dual Drug

Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis–encapsulation processes.

scholarly journals Quality by design prospects of pharmaceuticals application of double emulsion method for PLGA loaded nanoparticles

2021 ◽  
Vol 3 (6) ◽  
Author(s):  
Dhananjay Panigrahi ◽  
Pratap Kumar Sahu ◽  
Suryakanta Swain ◽  
Rajan Kumar Verma
Keyword(s):  
Drug Delivery ◽  
Quality By Design ◽  
Drug Product ◽  
Double Emulsion ◽  
Plga Nanoparticles ◽  
Influential Factors ◽  
Critical Material ◽  
Emulsion Method ◽  
Hydrophilic Drugs ◽  
Wide Range

Abstract QbD approach empowers the pharma researchers to minimize the number of experimental trials and time. It helps identify the significant, influential factors such as critical material attributes, critical formulation variables, and critical process parameters, which may significantly impact the quality of the products. Poly lactic-co-glycolic acid (PLGA), a biocompatible and biodegradable polymer, has gained an immense potential and wide range of applications as a carrier for manufacturing of polymeric nanoparticle drug delivery systems as per US-FDA and European Medicine Agency for drug delivery. The double emulsion method for preparing PLGA nanoparticles to encapsulate hydrophilic drugs has attracted interest in manufacturing processes. The double emulsion is a two-step process consisting of two different emulsification, making the process more complicated. The stability of nanoparticles obtained by a double emulsion method remains questionable due to the many formulations and process attributes. Currently, PLGA based nanoparticles prepared by a double emulsion technique are an alternative pharmaceutical manufacturing operation for getting the quality product by employing the Quality by Design approach. This present review has discussed the QbD elements to elucidate the effect of material attributes, formulation, and process variables on the critical quality attributes of the drug product, such as particle size distribution, encapsulation efficiency, etc. The components of a double emulsion, characteristics of drugs, polymers, and stabilizers used have been discussed in detail in this review. Graphic abstract

Dual drug delivery system of PLGA nanoparticles to reverse drug resistance by altering BAX/Bcl-2

2018 ◽  
Vol 47 ◽  
pp. 291-298 ◽  
Author(s):  
Farhad Alvandifar ◽  
Baharnaz Ghaffari ◽  
Navid Goodarzi ◽  
Nazanin Shabani Ravari ◽  
Fahimeh Karami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plga Nanoparticles ◽  
Dual Drug

Purification of Urokinase from Complex Mixtures Using Immobilized Monoclonal Antibody Against Urokinase Light Chain

1983 ◽  
Vol 49 (01) ◽  
pp. 024-027 ◽  
Author(s):  
David Vetterlein ◽  
Gary J Calton
Keyword(s):  
Monoclonal Antibody ◽  
Light Chain ◽  
Culture Media ◽  
Biological Fluids ◽  
Single Step ◽  
High Yield ◽  
Step Method ◽  
Commercial Preparation ◽  
E Coli ◽  
Tissue Culture Media

SummaryThe preparation of a monoclonal antibody (MAB) against high molecular weight (HMW) urokinase light chain (20,000 Mr) is described. This MAB was immobilized and the resulting immunosorbent was used to isolate urokinase starting with an impure commercial preparation, fresh urine, spent tissue culture media, or E. coli broth without preliminary dialysis or concentration steps. Monospecific antibodies appear to provide a rapid single step method of purifying urokinase, in high yield, from a variety of biological fluids.

Dual drug delivery of vancomycin and imipenem/cilastatin by coaxial nanofibers for treatment of diabetic foot ulcer infections

2021 ◽  
Vol 123 ◽  
pp. 111975
Author(s):  
Farideh Davani ◽  
Mohsen Alishahi ◽  
Mohammad Sabzi ◽  
Mohammad Khorram ◽  
Amir Arastehfar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Dual Drug

scholarly journals Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy

2021 ◽  
Vol 6 (8) ◽  
pp. 2372-2389
Author(s):  
Song Xue ◽  
Xiaojun Zhou ◽  
Weilin Sang ◽  
Cong Wang ◽  
Haiming Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeting Peptide ◽  
Nir Laser ◽  
Dual Drug

Star-Shaped Polylactide Dipyridamole Conjugated to 5-Fluorouracil and 4-Piperidinopiperidine Nanocarriers for Bioimaging and Dual Drug Delivery in Cancer Cells

2021 ◽  
Author(s):  
Dhanya Moorkoth ◽  
Kesavan Madhavan Nampoothiri ◽  
Selvaraj Nagarajan ◽  
Aswathy Ravindran Girija ◽  
Sivakumar Balasubramaniyan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Dual Drug
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