Preparation and biological performance of poly(vinyl alcohol)/hydroxyapatite porous composites used for cartilage repair

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 99940-99947 ◽  
Author(s):  
Wenting Qiu ◽  
Jia Wang ◽  
Li Li
Keyword(s):  
Porous Materials ◽  
Cartilage Repair ◽  
Vinyl Alcohol ◽  
Cell Structure ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
Blowing Agent ◽  
Biological Performance ◽  
Porous Composites

PVA/HA porous materials with proper cell structure and biological properties which were suitable for cartilage repair were prepared via thermoplastic foaming technique by using water/ethanol as co-blowing agent.

scholarly journals Effects of cryo-processing on the mechanical and biological properties of poly(vinyl alcohol)-gelatin theta-gels

2020 ◽  
Vol 15 (5) ◽  
pp. 051004 ◽  
Author(s):  
Patrick N. Charron ◽  
Jaime I. Jacobs ◽  
Selina X. Yao ◽  
Rachael A. Oldinski
Keyword(s):  
Vinyl Alcohol ◽  
Biological Properties ◽  
Poly Vinyl Alcohol

scholarly journals The use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffolds

RSC Advances ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 12346-12353 ◽  
Author(s):  
Petra Rejmontová ◽  
Adriana Kovalcik ◽  
Petr Humpolíček ◽  
Zdenka Capáková ◽  
Erik Wrzecionko ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Vinyl Alcohol ◽  
Biological Properties ◽  
Kraft Lignin ◽  
Poly Vinyl Alcohol

The mechanical properties of poly(vinyl alcohol) (PVA)-based scaffolds were successfully improved.

Superior physicochemical and biological properties of poly(vinyl alcohol)/sericin hydrogels fabricated by a non-toxic gamma-irradiation technique

2016 ◽  
Vol 32 (1) ◽  
pp. 32-44 ◽  
Author(s):  
Rungnapa Yamdej ◽  
Karnwalee Pangza ◽  
Teerapol Srichana ◽  
Pornanong Aramwit
Keyword(s):  
Gamma Irradiation ◽  
Vinyl Alcohol ◽  
Tensile Modulus ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
High Elongation ◽  
Physicochemical And Biological Properties ◽  
Migration Assays ◽  
Gamma Irradiated ◽  
High Degree

Gamma irradiation was used to fabricate crosslinked poly(vinyl alcohol)/sericin hydrogels with different sericin concentrations, and the physicochemical and biological properties of the gamma-irradiated poly(vinyl alcohol)/sericin hydrogels were characterized. Following gamma irradiation, the hydrogels had a high gel fraction (80%–95%), implying a high degree of crosslinking. Fourier transform infrared spectra confirmed the crosslinking bonds within the hydrogels, as seen by the characteristic shift in the peak. Furthermore, a low tensile modulus together with a high elongation percentage indicated that the hydrogels were easy to handle. We also showed that all hydrogels released sericin simultaneously. The poly(vinyl alcohol)/sericin hydrogels with high sericin content released more sericin, possibly due to less crosslinking of the hydrogels. When L929 cells were cultured with the hydrogel extracts, the cells were viable and could proliferate, particularly for the cells cultured with the hydrogels containing a high sericin content, which released more sericin. Migration assays also demonstrated that the cells migrated toward the medium extract of hydrogels containing high sericin. We suggest that sterile gamma-irradiated poly(vinyl alcohol)/sericin hydrogels could be used as a wound dressing for the treatment of dry and low-exudate wounds.

Hydroxyapatite-Poly(Vinyl Alcohol)-Sodium Alginate Porous Hydrogels with Poly(Vinyl Alcohol) Surface Layer Used for Articular Cartilage Repair

2016 ◽  
Vol 852 ◽  
pp. 1155-1161 ◽  
Author(s):  
Xiao Bing Luo ◽  
Ming Feng Ma ◽  
Xian Ju Zhou
Keyword(s):  
Articular Cartilage ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
X Ray ◽  
Composite Hydrogels ◽  
Good Potential ◽  
Gas Foaming

The double-layered PVA/nanohydroxyapatite (nHA)-poly (vinyl alcohol)(PVA)-sodium alginate (SA) porous composite scaffolds used as synthetic articular cartilage were prepared by the freeze-thawing method, gas foaming method and crosslink method of Ca2+ ion, i.e., upper PVA layer for the cartilage substitute and underlying SA30 porous hydrogels for bone bonding. The microstructure and morphology of composite hydrogels were characterized using scanning electronic microscopy (SEM).It had high porosity and uniform pores. The content of HA in SA30 matrix were tested by Energy-dispersive X-ray spectroscopy (EDS). The biological properties of the composite hydrogels had been evaluated by co-culture and MTT. All results indicate that the PVA/SA30 hydrogels has good potential for repairing or replacing articular cartilage.

Fabrication of curcumin-loaded gum tragacanth/poly(vinyl alcohol) nanofibers with optimized electrospinning parameters

2016 ◽  
Vol 46 (5) ◽  
pp. 1170-1192 ◽  
Author(s):  
Marziyeh Ranjbar-Mohammadi ◽  
Saeid Kargozar ◽  
S Hajir Bahrami ◽  
MT Joghataei
Keyword(s):  
Response Surface ◽  
Vinyl Alcohol ◽  
Polymer Concentration ◽  
Back Propagation ◽  
Average Diameter ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
Surface Model ◽  
Back Propagation Algorithm ◽  
Gum Tragacanth

This paper focuses on using response surface methodology (RSM) and artificial neural network (ANN) to optimize the diameter of Gum tragacanth (GT)/poly(vinyl alcohol) (PVA) nanofibers. However, producing curcumin-loaded GT/PVA nanofibers with using these optimized conditions is another aim. RSM methodology based on four variables (voltage, feed rate, distance between nozzle and collector, and solution concentration) with three levels and ANN technique were compared for modeling the average diameter of nanofibers. In the RSM method, the individual and interaction effects between the parameters on the average diameter of nanofibers were determined using Box-Behnken design (BBD). Data sets of input–output patterns were used for training the multilayer perceptron (MP) neural networks trained with back-propagation algorithm for modeling purpose. Experimental results for both ANN and RSM techniques showed agreement with the predicted fiber diameter. High-regression coefficient between the variables and the response displayed that the performance of RSM for minimizing diameter of nanofibers was better than ANN. Based on response surface model, optimum conditions (polymer concentration of 4.2% (w/v), distance between the capillary and collector 20 cm, applied voltage of 20 kV and flow rate of 0.5 mL/h) were obtained for producing GT/PVA nanofibers with minimized diameter. Then curcumin-loaded GT/PVA nanofibers were produced with acquired optimum condition and the effect of curcumin concentration (3 and 5% (w/v)) on the morphology, diameter and biological properties of nanofibers was investigated.

scholarly journals Evaluation in Cellulose Nanocrystals Effectiveness on Composite Film based Wound Dressing from Poly(vinyl alcohol) and Gum Tragacanth

2021 ◽  
Author(s):  
Luong Ngoc Diem ◽  
Indranil Banerjee ◽  
Kunal Pal ◽  
Udomlak Sukatta ◽  
Prapassorn Rugthaworn ◽  
...  
Keyword(s):  
Composite Film ◽  
Polymer Matrix ◽  
Cellulose Nanocrystals ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

Abstract Biomaterial-based wound dressings were fabricated using cellulose nanocrystals (CNCs) as nano-filler in a polymeric mixture of poly(vinyl alcohol) (PVA) and gum tragacanth (GT) via solution casting. Physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentrations (2 to 10%) of CNCs were observed. Initial analysis of CNCs showed nanosized particles of 104 nm length and 7 nm width. Scanning electron microscopy (SEM) illustrated cluster formations of CNCs in the polymer matrix. Fourier transform infrared (FTIR) spectrometry was used to confirm the chemical functional groups in the material. The presence of GT and CNCs in the polymer matrix improved water uptake and prolonged stability for 7 days. The CNCs enhanced tensile strength from 54.63 MPa to 80.39MPa. Biological properties of PVA/GT/CNC films were analyzed. Results showed that the dressing material was nontoxic to mouse fibroblast cells L929, while film loaded with betel leaf extract exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film was suitable for application in wound dressing.

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