Fabrication of curcumin-loaded gum tragacanth/poly(vinyl alcohol) nanofibers with optimized electrospinning parameters

2016 ◽  
Vol 46 (5) ◽  
pp. 1170-1192 ◽  
Author(s):  
Marziyeh Ranjbar-Mohammadi ◽  
Saeid Kargozar ◽  
S Hajir Bahrami ◽  
MT Joghataei
Keyword(s):  
Response Surface ◽  
Vinyl Alcohol ◽  
Polymer Concentration ◽  
Back Propagation ◽  
Average Diameter ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
Surface Model ◽  
Back Propagation Algorithm ◽  
Gum Tragacanth

This paper focuses on using response surface methodology (RSM) and artificial neural network (ANN) to optimize the diameter of Gum tragacanth (GT)/poly(vinyl alcohol) (PVA) nanofibers. However, producing curcumin-loaded GT/PVA nanofibers with using these optimized conditions is another aim. RSM methodology based on four variables (voltage, feed rate, distance between nozzle and collector, and solution concentration) with three levels and ANN technique were compared for modeling the average diameter of nanofibers. In the RSM method, the individual and interaction effects between the parameters on the average diameter of nanofibers were determined using Box-Behnken design (BBD). Data sets of input–output patterns were used for training the multilayer perceptron (MP) neural networks trained with back-propagation algorithm for modeling purpose. Experimental results for both ANN and RSM techniques showed agreement with the predicted fiber diameter. High-regression coefficient between the variables and the response displayed that the performance of RSM for minimizing diameter of nanofibers was better than ANN. Based on response surface model, optimum conditions (polymer concentration of 4.2% (w/v), distance between the capillary and collector 20 cm, applied voltage of 20 kV and flow rate of 0.5 mL/h) were obtained for producing GT/PVA nanofibers with minimized diameter. Then curcumin-loaded GT/PVA nanofibers were produced with acquired optimum condition and the effect of curcumin concentration (3 and 5% (w/v)) on the morphology, diameter and biological properties of nanofibers was investigated.

scholarly journals Evaluation in Cellulose Nanocrystals Effectiveness on Composite Film based Wound Dressing from Poly(vinyl alcohol) and Gum Tragacanth

2021 ◽  
Author(s):  
Luong Ngoc Diem ◽  
Indranil Banerjee ◽  
Kunal Pal ◽  
Udomlak Sukatta ◽  
Prapassorn Rugthaworn ◽  
...  
Keyword(s):  
Composite Film ◽  
Polymer Matrix ◽  
Cellulose Nanocrystals ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

Abstract Biomaterial-based wound dressings were fabricated using cellulose nanocrystals (CNCs) as nano-filler in a polymeric mixture of poly(vinyl alcohol) (PVA) and gum tragacanth (GT) via solution casting. Physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentrations (2 to 10%) of CNCs were observed. Initial analysis of CNCs showed nanosized particles of 104 nm length and 7 nm width. Scanning electron microscopy (SEM) illustrated cluster formations of CNCs in the polymer matrix. Fourier transform infrared (FTIR) spectrometry was used to confirm the chemical functional groups in the material. The presence of GT and CNCs in the polymer matrix improved water uptake and prolonged stability for 7 days. The CNCs enhanced tensile strength from 54.63 MPa to 80.39MPa. Biological properties of PVA/GT/CNC films were analyzed. Results showed that the dressing material was nontoxic to mouse fibroblast cells L929, while film loaded with betel leaf extract exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film was suitable for application in wound dressing.

Preparation and characterization of poly(vinyl alcohol)/gum tragacanth/cellulose nanocomposite film

2021 ◽  
pp. 50672
Author(s):  
Majid Alizadeh Moghadam ◽  
Reza Mohammadi ◽  
Ehsan Sadeghi ◽  
Mohammad Amin Mohammadifar ◽  
Mohammad Nejatian ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Nanocomposite Film ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

scholarly journals Development of poly(vinyl alcohol)-based membranes by the response surface methodology for environmental applications

2020 ◽  
Vol 24 ◽  
pp. e5
Author(s):  
Juliana Zanol Merck ◽  
Camila Suliani Raota ◽  
Jocelei Duarte ◽  
Camila Baldasso ◽  
Janaina Da Silva Crespo ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Citric Acid ◽  
Response Surface ◽  
Acid Concentration ◽  
Vinyl Alcohol ◽  
Membrane Preparation ◽  
Poly Vinyl Alcohol ◽  
Esterification Reaction ◽  
Citric Acid Concentration ◽  
Ft Ir

The pollution of hydric sources by pharmaceuticals is an issue in many countries, particularly in Brazil. The presence of these substances causes deleterious effects on the environment and human health. One of the main sources of this contamination is domestic sewage, due to the expressive amount of medicines released in their unaltered form. Unfortunately, traditional wastewater treatment is not effective for the removal of pharmaceuticals and, for this reason, membrane technology is an attractive alternative to overcome this issue. In this regard, hydrophilic polymers, such as poly(vinyl alcohol) (PVA), are the most suitable. However, their high affinity with water causes intense swelling, leading to severe modifications in the membrane properties. In view of all these facts, the present work evaluated the swelling of PVA-based membranes, with the aim of finding the membrane preparation method that has the lowest swelling, thereby providing the most suitable characteristics for pharmaceutical removal from wastewater. The membranes were prepared by the casting of a polymeric solution, with PVA as a basis polymer, citric acid as a crosslink agent and glycerol and silver nanoparticles as performance additives. The process optimization was performed using a design of experiments with posterior analysis by the response surface methodology (RSM). The RSM assessed the effect on the membrane swelling of the factors, including citric acid concentration and the time and temperature of crosslinking. The membrane characterization was performed by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy coupled with a field emission gun (SEM-FEG) and water contact angle (WCA) measurements. Overall, the condition that showed the lowest swelling was obtained with 10% of citric acid and crosslinking for 4 h at 130 °C. Under these conditions, the membrane had a mass swelling of 42% and a dimensional swelling of 24%. Additionally, our statistical analysis revealed that the factors with the dominant effects were the citric acid concentration and the temperature of crosslinking. The FT-IR analysis suggested that the crosslinking occurred by an esterification reaction, as showed by the stretching frequencies of C=O at 1710 cm-1 and ester C-O at 1230 cm-1. Moreover, the SEM-FEG images revealed a smooth and flat surface and a dense cross section with a thickness of ~113 μm. Concerning the WCA, the angle was at ~80°, which is characteristic of hydrophilic materials. Finally, the data suggested that it is possible to optimize the membrane preparation process with adequate properties so that it can be subsequently applied to the removal of pharmaceuticals from hospital wastewater.

scholarly journals Effects of cryo-processing on the mechanical and biological properties of poly(vinyl alcohol)-gelatin theta-gels

2020 ◽  
Vol 15 (5) ◽  
pp. 051004 ◽  
Author(s):  
Patrick N. Charron ◽  
Jaime I. Jacobs ◽  
Selina X. Yao ◽  
Rachael A. Oldinski
Keyword(s):  
Vinyl Alcohol ◽  
Biological Properties ◽  
Poly Vinyl Alcohol

scholarly journals The use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffolds

RSC Advances ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 12346-12353 ◽  
Author(s):  
Petra Rejmontová ◽  
Adriana Kovalcik ◽  
Petr Humpolíček ◽  
Zdenka Capáková ◽  
Erik Wrzecionko ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Vinyl Alcohol ◽  
Biological Properties ◽  
Kraft Lignin ◽  
Poly Vinyl Alcohol

The mechanical properties of poly(vinyl alcohol) (PVA)-based scaffolds were successfully improved.

Superior physicochemical and biological properties of poly(vinyl alcohol)/sericin hydrogels fabricated by a non-toxic gamma-irradiation technique

2016 ◽  
Vol 32 (1) ◽  
pp. 32-44 ◽  
Author(s):  
Rungnapa Yamdej ◽  
Karnwalee Pangza ◽  
Teerapol Srichana ◽  
Pornanong Aramwit
Keyword(s):  
Gamma Irradiation ◽  
Vinyl Alcohol ◽  
Tensile Modulus ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
High Elongation ◽  
Physicochemical And Biological Properties ◽  
Migration Assays ◽  
Gamma Irradiated ◽  
High Degree

Gamma irradiation was used to fabricate crosslinked poly(vinyl alcohol)/sericin hydrogels with different sericin concentrations, and the physicochemical and biological properties of the gamma-irradiated poly(vinyl alcohol)/sericin hydrogels were characterized. Following gamma irradiation, the hydrogels had a high gel fraction (80%–95%), implying a high degree of crosslinking. Fourier transform infrared spectra confirmed the crosslinking bonds within the hydrogels, as seen by the characteristic shift in the peak. Furthermore, a low tensile modulus together with a high elongation percentage indicated that the hydrogels were easy to handle. We also showed that all hydrogels released sericin simultaneously. The poly(vinyl alcohol)/sericin hydrogels with high sericin content released more sericin, possibly due to less crosslinking of the hydrogels. When L929 cells were cultured with the hydrogel extracts, the cells were viable and could proliferate, particularly for the cells cultured with the hydrogels containing a high sericin content, which released more sericin. Migration assays also demonstrated that the cells migrated toward the medium extract of hydrogels containing high sericin. We suggest that sterile gamma-irradiated poly(vinyl alcohol)/sericin hydrogels could be used as a wound dressing for the treatment of dry and low-exudate wounds.

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