Targeting G-quadruplex DNA and B-DNA with a natural alkaloid: a comparative spectroscopic study

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 109846-109856 ◽  
Author(s):  
Paulami Mandal ◽  
Maitree Bhattacharya ◽  
Joydeep Chowdhury
Keyword(s):  
Molecular Recognition ◽  
Spectroscopic Study ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Natural Alkaloid

Different modes of binding of natural alkaloid harmine with G-quadruplex DNA and B-DNA: key roles in molecular recognition.

Molecular recognition of parallel quadruplex [d-(TTGGGGT)]4 by mitoxantrone: binding with 1 : 4 stoichiometry leads to telomerase inhibition

RSC Advances ◽  
2016 ◽  
Vol 6 (75) ◽  
pp. 71652-71661 ◽  
Author(s):  
Tarikere Palakshan Pradeep ◽  
Sweta Tripathi ◽  
Ritu Barthwal
Keyword(s):  
Molecular Recognition ◽  
Thermal Stabilization ◽  
Cancer Drug ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Anti Cancer ◽  
G Quadruplex ◽  
Cd Studies

NMR and CD studies show that anti-cancer drug mitoxantrone (MTX) binds to parallel G-quadruplex DNA [d-(TTGGGGT)4] as stacked dimer at grooves leading to increase in thermal stabilization of DNA by ~25 °C and inhibits telomerase with IC50 = 2 μM.

scholarly journals The Thermodynamic Effects of Ligand Structure on the Molecular Recognition of Mono- and Biruthenium Polypyridyl Complexes with G-Quadruplex DNA

2017 ◽  
Vol 2017 (33) ◽  
pp. 3953-3960 ◽  
Author(s):  
Clinton G. Mikek ◽  
Venkata R. Machha ◽  
Jake C. White ◽  
Logan R. Martin ◽  
Savannah J. West ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Polypyridyl Complexes ◽  
Quadruplex Dna ◽  
Ligand Structure ◽  
G Quadruplex ◽  
Thermodynamic Effects

A single-molecule force-spectroscopic study on stabilization of G-quadruplex DNA by a telomerase inhibitor

The Analyst ◽  
2014 ◽  
Vol 139 (16) ◽  
pp. 4037-4043 ◽  
Author(s):  
Ryoto Funayama ◽  
Yoshio Nakahara ◽  
Shinpei Kado ◽  
Mutsuo Tanaka ◽  
Keiichi Kimura
Keyword(s):  
Spectroscopic Study ◽  
Single Molecule ◽  
Quadruplex Dna ◽  
Telomerase Inhibitor ◽  
G Quadruplex

The stabilization of G-quadruplex DNA by a telomerase inhibitor was semi-quantitatively evaluated by AFM-based SMFS.

Spectroscopic study and G-quadruplex DNA binding affinity of two bioactive papaverine-derived ligands

2007 ◽  
Vol 41 (5) ◽  
pp. 558-563 ◽  
Author(s):  
Elzbieta Galezowska ◽  
Anna Masternak ◽  
Blazej Rubis ◽  
Artur Czyrski ◽  
Maria Rybczyńska ◽  
...  
Keyword(s):  
Dna Binding ◽  
Spectroscopic Study ◽  
Binding Affinity ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Affinity

scholarly journals Correction: A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 22931-22931
Author(s):  
Dongli Li ◽  
Jin-Qiang Hou ◽  
Wei Long ◽  
Yu-Jing Lu ◽  
Wing-Leung Wong ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Specific Binding ◽  
Amino Group ◽  
Group Interactions ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Recognition Ability

Correction for ‘A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions’ by Dongli Li et al., RSC Adv., 2018, 8, 20222–20227.

Molecular recognition of G-quadruplex DNA by Pheophorbide a

2021 ◽  
Author(s):  
China Okamoto ◽  
Atsuya Momotake ◽  
Masami Kobayashi ◽  
Yasuhiko Yamamoto
Keyword(s):  
Molecular Recognition ◽  
Pheophorbide A ◽  
Quadruplex Dna ◽  
G Quadruplex
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