β,β-Dialkyl γ-amino γ-trifluoromethyl alcohols from trifluoromethyl (E)-aldimines by a one-pot solvent-free Mannich-type reaction and subsequent reduction

Stefania Fioravanti; Federico Mancinelli; Luca Parise; Alessia Pelagalli; Lucio Pellacani; Laura Trulli

doi:10.1039/c6ra22507a

β,β-Dialkyl γ-amino γ-trifluoromethyl alcohols from trifluoromethyl (E)-aldimines by a one-pot solvent-free Mannich-type reaction and subsequent reduction

RSC Advances ◽

10.1039/c6ra22507a ◽

2016 ◽

Vol 6 (104) ◽

pp. 101862-101868 ◽

Cited By ~ 1

Author(s):

Stefania Fioravanti ◽

Federico Mancinelli ◽

Luca Parise ◽

Alessia Pelagalli ◽

Lucio Pellacani ◽

...

Keyword(s):

Solvent Free ◽

Subsequent Reduction ◽

One Pot ◽

Type Reaction

A diastereoselective one-pot solvent-free Mannich-type addition of α-alkyl aldehydes to trifluoromethyl (E)-aldimines, which first act as bases and then as electrophiles, leads to β,β-dialkyl γ-amino γ-CF3 alcohols in good yields, after reduction.

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Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol

Molecular Diversity ◽

10.1007/s11030-014-9559-x ◽

2014 ◽

Vol 19 (1) ◽

pp. 87-101 ◽

Cited By ~ 19

Author(s):

Aziz Shahrisa ◽

Reza Teimuri-Mofrad ◽

Mahdi Gholamhosseini-Nazari

Keyword(s):

Solvent Free ◽

One Pot ◽

Type Reaction ◽

New Class

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Bronsted acidic ionic liquid [C 3 SO 3 HDoim]HSO 4 catalyzed one-pot three-component Biginelli-type reaction: An efficient and solvent-free synthesis of pyrimidinone derivatives and its mechanistic study

Chinese Chemical Letters ◽

10.1016/j.cclet.2015.10.010 ◽

2016 ◽

Vol 27 (2) ◽

pp. 226-230 ◽

Cited By ~ 8

Author(s):

Zhi-Lei Zhou ◽

Peng-Cheng Wang ◽

Ming Lu

Keyword(s):

Ionic Liquid ◽

Solvent Free ◽

Mechanistic Study ◽

One Pot ◽

Type Reaction ◽

Acidic Ionic Liquid ◽

Brønsted Acidic Ionic Liquid ◽

Solvent Free Synthesis

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ChemInform Abstract: Broensted Acidic Ionic Liquid [C3SO3HDoim]HSO4Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient and Solvent-Free Synthesis of Pyrimidinone Derivatives and Its Mechanistic Study.

ChemInform ◽

10.1002/chin.201627190 ◽

2016 ◽

Vol 47 (27) ◽

Author(s):

Zhi-Lei Zhou ◽

Peng-Cheng Wang ◽

Ming Lu

Keyword(s):

Ionic Liquid ◽

Solvent Free ◽

Mechanistic Study ◽

One Pot ◽

Type Reaction ◽

Acidic Ionic Liquid ◽

Solvent Free Synthesis

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An efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones/imines via a Lewis base catalyzed Biginelli-type reaction under solvent-free conditions

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2011.09.018 ◽

2016 ◽

Vol 9 ◽

pp. S846-S851 ◽

Cited By ~ 19

Author(s):

S. Sheik Mansoor ◽

S. Syed Shafi ◽

S. Zaheer Ahmed

Keyword(s):

Solvent Free ◽

Lewis Base ◽

Multicomponent Synthesis ◽

One Pot ◽

Type Reaction ◽

Solvent Free Conditions

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ChemInform Abstract: Broensted Acidic Ionic Liquid as an Efficient and Reusable Catalyst for One-Pot, Three-Component Synthesis of Pyrimidinone Derivatives via Biginelli-Type Reaction under Solvent-Free Conditions.

ChemInform ◽

10.1002/chin.201202169 ◽

2011 ◽

Vol 43 (2) ◽

pp. no-no

Author(s):

Abdol R. Hajipour ◽

Yosof Ghayeb ◽

Nafisehsadat Sheikhan ◽

Arnold E. Ruoho

Keyword(s):

Ionic Liquid ◽

Solvent Free ◽

Reusable Catalyst ◽

One Pot ◽

Type Reaction ◽

Acidic Ionic Liquid ◽

Solvent Free Conditions

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Brønsted Acidic Ionic Liquid as an Efficient and Reusable Catalyst for One-Pot, Three-Component Synthesis of Pyrimidinone Derivatives via Biginelli-Type Reaction Under Solvent-Free Conditions

Synthetic Communications ◽

10.1080/00397911.2010.501474 ◽

2011 ◽

Vol 41 (15) ◽

pp. 2226-2233 ◽

Cited By ~ 22

Author(s):

Abdol R. Hajipour ◽

Yosof Ghayeb ◽

Nafisehsadat Sheikhan ◽

Arnold E. Ruoho

Keyword(s):

Ionic Liquid ◽

Solvent Free ◽

Reusable Catalyst ◽

One Pot ◽

Type Reaction ◽

Acidic Ionic Liquid ◽

Brønsted Acidic Ionic Liquid ◽

Solvent Free Conditions

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Eco-friendly one-pot, three-component synthesis of novel derivatives of kojic acid by the Mannich-type reaction under solvent-free ball-milling conditions

Research on Chemical Intermediates ◽

10.1007/s11164-015-2221-0 ◽

2015 ◽

Vol 42 (4) ◽

pp. 3425-3439 ◽

Cited By ~ 16

Author(s):

Reza Teimuri-Mofrad ◽

Aziz Shahrisa ◽

Mahdi Gholamhosseini-Nazari ◽

Naser Arsalani

Keyword(s):

Ball Milling ◽

Kojic Acid ◽

Solvent Free ◽

One Pot ◽

Type Reaction ◽

Derivatives Of

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(±)-Camphor-10-sulfonic acid catalyzed direct one-pot three-component Mannich type reaction of alkyl (hetero)aryl ketones under solvent-free conditions: application to the synthesis of aminochromans

RSC Advances ◽

10.1039/c1ra00652e ◽

2012 ◽

Vol 2 (2) ◽

pp. 480-486 ◽

Cited By ~ 15

Author(s):

Kshama Kundu ◽

Sandip K. Nayak

Keyword(s):

Sulfonic Acid ◽

Solvent Free ◽

One Pot ◽

Type Reaction ◽

Solvent Free Conditions ◽

Aryl Ketones ◽

Acid Catalyzed

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ChemInform Abstract: (.+-.)-Camphor-10-sulfonic Acid Catalyzed Direct One-Pot Three-Component Mannich Type Reaction of Alkyl (Hetero)aryl Ketones under Solvent-Free Conditions: Application to the Synthesis of Aminochromans.

ChemInform ◽

10.1002/chin.201221062 ◽

2012 ◽

Vol 43 (21) ◽

pp. no-no

Author(s):

Kshama Kundu ◽

Sandip K. Nayak

Keyword(s):

Sulfonic Acid ◽

Solvent Free ◽

One Pot ◽

Type Reaction ◽

Solvent Free Conditions ◽

Aryl Ketones ◽

Acid Catalyzed

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Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190325120715 ◽

2019 ◽

Vol 22 (2) ◽

pp. 123-128

Author(s):

Setareh Habibzadeh ◽

Hassan Ghasemnejad-Bosra ◽

Mina Haghdadi ◽

Soheila Heydari-Parastar

Keyword(s):

Carboxylic Acid ◽

Fe3o4 Nanoparticles ◽

High Efficiency ◽

Reaction Times ◽

Chlorosulfonic Acid ◽

Aromatic Aldehydes ◽

Solvent Free ◽

Magnetic Nanocatalyst ◽

One Pot ◽

Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

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