ChemInform Abstract: Broensted Acidic Ionic Liquid [C3SO3HDoim]HSO4Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient and Solvent-Free Synthesis of Pyrimidinone Derivatives and Its Mechanistic Study.

ChemInform ◽  
2016 ◽  
Vol 47 (27) ◽  
Author(s):  
Zhi-Lei Zhou ◽  
Peng-Cheng Wang ◽  
Ming Lu
Keyword(s):  
Ionic Liquid ◽  
Solvent Free ◽  
Mechanistic Study ◽  
One Pot ◽  
Type Reaction ◽  
Acidic Ionic Liquid ◽  
Solvent Free Synthesis

ChemInform Abstract: Highly Efficient, One-Pot, Solvent-Free Synthesis of 2,4,6-Triarylpyridines Using a Broensted-Acidic Ionic Liquid as Reusable Catalyst.

ChemInform ◽  
2010 ◽  
Vol 42 (1) ◽  
pp. no-no
Author(s):  
Abolghasem Davoodnia ◽  
Mehdi Bakavoli ◽  
Raheleh Moloudi ◽  
Niloofar Tavakoli-Hoseini ◽  
Maryam Khashi
Keyword(s):  
Ionic Liquid ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
Acidic Ionic Liquid ◽  
Highly Efficient ◽  
Solvent Free Synthesis

Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst

2016 ◽  
Vol 70 (8) ◽  
Author(s):  
Heshmatollah Alinezhad ◽  
Mahmood Tajbakhsh ◽  
Mahboobeh Zare ◽  
Mahbooeh Mousavi
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
Organic Solvents ◽  
Simple Procedure ◽  
Solvent Free ◽  
One Pot ◽  
Efficient Catalyst ◽  
Short Reaction Time ◽  
Acidic Ionic Liquid ◽  
Solvent Free Synthesis

AbstractA one-pot three-component Biginelli-like reaction of enaminones, aldehydes with urea/thiourea in the presence of 2-pyrrolidonium bisulphate as an acidic ionic liquid catalyst for the preparation of 6-unsubstituted dihydropyrimidinones is described. The excellent yield, short reaction time, simple procedure and avoidance of the use of organic solvents are some advantages of this method.

1, 1’-Sulfinyldiethylammonium Bis (Hydrogen Sulfate) as a Recyclable Dicationic Ionic Liquid Catalyst for the Efficient Solvent-free Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction

2020 ◽  
Vol 23 (2) ◽  
pp. 157-167
Author(s):  
Zainab Ehsani-Nasab ◽  
Ali Ezabadi
Keyword(s):  
Ionic Liquid ◽  
Biginelli Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Hydrogen Sulfate ◽  
One Pot ◽  
Acidic Ionic Liquid ◽  
Brønsted Acidic Ionic Liquid ◽  
Solvent Free Conditions ◽  
Dicationic Ionic Liquid

Objective: A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Brönsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been successfully developed. Material and Method:: 3, 4-Dihydropyrimidin-2(1H)-ones were synthesized through one-pot condensation of aromatic aldehydes, ethyl acetoacetate, and urea under solvent-free conditions using [(EtNH2)2SO][HSO4]2 as a novel catalyst. The progress of the reaction was monitored by thin-layer chromatography (ethyl acetate / n-hexane = 1 / 5). The products have been characterized by IR, 1H NMR, 13C NMR, and also by their melting points. Results: In this research, a library of dihydropyrimidinone derivatives was synthesized via Biginelli reaction under solvent-free conditions at 120oC using [(EtNH2)2SO][HSO4]2 as a catalyst. Various aromatic aldehydes, as well as heteroaromatic aldehydes, were employed, affording good to high yields of the corresponding products and illustrating the substrate generality of the present method. In addition, the prepared dicationic Brönsted acidic ionic liquid can be easily recovered and reused. Conclusion: 1, 1’-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions.

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