Novel ibuprofenate- and docusate-based ionic liquids: emergence of antimicrobial activity

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100476-100486 ◽  
Author(s):  
Clarissa P. Frizzo ◽  
Keli Wust ◽  
Aniele Z. Tier ◽  
Thaíssa S. Beck ◽  
Leticia V. Rodrigues ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Molecular Structures ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Six new ionic-liquid-based active pharmaceutical ingredients (IL-APIs) were prepared and their molecular structures characterized.

Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

MedChemComm ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 559 ◽  
Author(s):  
O. Andreea Cojocaru ◽  
Katharina Bica ◽  
Gabriela Gurau ◽  
Asako Narita ◽  
Parker D. McCrary ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Liquid Form ◽  
Pharmaceutical Ingredients

scholarly journals Ionic Liquids as Active Pharmaceutical Ingredients

ChemMedChem ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. 975-985 ◽  
Author(s):  
Ricardo Ferraz ◽  
Luís C. Branco ◽  
Cristina Prudêncio ◽  
João Paulo Noronha ◽  
Željko Petrovski
Keyword(s):  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

The third evolution of ionic liquids: active pharmaceutical ingredients

2007 ◽  
Vol 31 (8) ◽  
pp. 1429 ◽  
Author(s):  
Whitney L. Hough ◽  
Marcin Smiglak ◽  
Héctor Rodríguez ◽  
Richard P. Swatloski ◽  
Scott K. Spear ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
The Third

scholarly journals The A Priori Design and Selection of Ionic Liquids as Solvents for Active Pharmaceutical Ingredients

2017 ◽  
Vol 23 (23) ◽  
pp. 5498-5508 ◽  
Author(s):  
Andreas J. Kunov‐Kruse ◽  
Cameron C. Weber ◽  
Robin D. Rogers ◽  
Allan S. Myerson
Keyword(s):  
Ionic Liquids ◽  
A Priori ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Selection Of

Thermodynamic Properties of Flufenamic Ionic Liquids

2014 ◽  
Vol 625 ◽  
pp. 586-591
Author(s):  
Fatimah Julia Romeli ◽  
Cecilia Devi Wilfred ◽  
Anis Shuib
Keyword(s):  
Thermal Stability ◽  
Ionic Liquids ◽  
Thermodynamic Properties ◽  
Molecular Volume ◽  
Standard Entropy ◽  
Active Pharmaceutical Ingredients ◽  
Density Data ◽  
Pharmaceutical Ingredients ◽  
Increasing Temperature ◽  
Experimental Density

Active pharmaceutical ingredients-ionic liquids (APIs-ILs) in which, when compared to active pharmaceutical ingredients hydrochloride (APIs-HCl), exhibits better solubility, increased thermal stability and significant enhancement in the efficiency of APIs. Three novel flufenamic-ILs were synthesized and their density and viscosities were determined and reported as a function of temperature. From the experimental density data the crystal energy, molecular volume and standard entropy was estimated. The result showed that the density and viscosities decrease with increasing temperature in these four ionic liquids.

scholarly journals Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 200
Author(s):  
Fátima A. R. Mota ◽  
Sarah A. P. Pereira ◽  
André R. T. S. Araujo ◽  
M. Lúcia M. F. S. Saraiva
Keyword(s):  
Enzyme Activity ◽  
Ionic Liquids ◽  
Sodium Salicylate ◽  
Raw Material ◽  
Human Neutrophil Elastase ◽  
Active Pharmaceutical Ingredients ◽  
Diagnostic Biomarker ◽  
Significant Information ◽  
Pharmaceutical Ingredients

Human neutrophil elastase (HNE) is used as diagnostic biomarker for inflammation/infection. In this work, 10 ionic liquids (ILs) and 11 ionic liquids active pharmaceutical ingredients (ILs-APIs) were tested to evaluate the inhibition effect on the activity of porcine pancreatic elastase enzyme, frequently employed as a model for HNE. The insertion of ionic liquids in some drugs is useful, as the insertion of ILs with inhibitory capacity will also slow down all processes in which this enzyme is involved. Therefore, a spectrophotometric method was performed to the determination of EC50 values of the compounds tested. EC50 values of 124 ± 4 mM to 289 ± 11 mM were obtained, with the most toxic IL for elastase being tetrabutylammonium acetate and the least toxic 1-butyl-3-methylimidazolium acetate. Moreover, sodium salicylate (raw material) presented the lower and benzethonium bistriflimide the higher EC50 when compared with all the IL-APIs tested. This work provides significant information about the effect of the studied IL and IL-APIs in elastase enzyme activity.

scholarly journals Technology administration active substance in the ointment base

2019 ◽  
pp. 38-42
Author(s):  
V. V. Trochimchuk ◽  
V. V. Shmatenko ◽  
V. O. Tarasenko ◽  
A. O. Drozdova
Keyword(s):  
Antimicrobial Activity ◽  
Military Medicine ◽  
Experimental Studies ◽  
Active Pharmaceutical Ingredients ◽  
Optimal Method ◽  
Pharmaceutical Ingredients ◽  
Solid Agar ◽  
Ointment Base ◽  
Important Challenge ◽  
Technological Route

The problem of expanding the range of medicines that are used for the topical treatment of wound process, remains an important challenge for practical military medicine. In this aspect, there are topical ointments combining development for use in the first phase of wound process, which has a complex influence on the pathological processes and exhibits antibacterial, anti-inflammatory and local anesthetic activity. The aim of the study was substantiation of technological route of administration of the active pharmaceutical ingredients in the ointment base, depending on the antimicrobial activity of model compositions. The study included a model sample of ointment bases, cooked on a hydrophilic carrier containing active pharmaceutical ingredients – ofloxacin, nimesulide and lidocaine. Microbiological studies were performed by difution on solid agar medium, which is based on the ability of substances to inhibit the growth antibakterial microorganisms. Comparative analysis of experimental studies showed that the samples of ointments, which are based whith the active pharmaceutical ingredients ofloxacin, nimesulide and lidocaine was injected as a solution in DMSO showed the highest antimicrobial activity. As a result of study on the antimicrobial activity of ointments model samples determined that the optimal method of administering the basis AFI – ofloxacin, nimesulide and lidocaine – a method of administering them in the form of a solution in DMSO.

Sign in / Sign up

Export Citation Format

Share Document