scholarly journals Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 200
Author(s):  
Fátima A. R. Mota ◽  
Sarah A. P. Pereira ◽  
André R. T. S. Araujo ◽  
M. Lúcia M. F. S. Saraiva
Keyword(s):  
Enzyme Activity ◽  
Ionic Liquids ◽  
Sodium Salicylate ◽  
Raw Material ◽  
Human Neutrophil Elastase ◽  
Active Pharmaceutical Ingredients ◽  
Diagnostic Biomarker ◽  
Significant Information ◽  
Pharmaceutical Ingredients

Human neutrophil elastase (HNE) is used as diagnostic biomarker for inflammation/infection. In this work, 10 ionic liquids (ILs) and 11 ionic liquids active pharmaceutical ingredients (ILs-APIs) were tested to evaluate the inhibition effect on the activity of porcine pancreatic elastase enzyme, frequently employed as a model for HNE. The insertion of ionic liquids in some drugs is useful, as the insertion of ILs with inhibitory capacity will also slow down all processes in which this enzyme is involved. Therefore, a spectrophotometric method was performed to the determination of EC50 values of the compounds tested. EC50 values of 124 ± 4 mM to 289 ± 11 mM were obtained, with the most toxic IL for elastase being tetrabutylammonium acetate and the least toxic 1-butyl-3-methylimidazolium acetate. Moreover, sodium salicylate (raw material) presented the lower and benzethonium bistriflimide the higher EC50 when compared with all the IL-APIs tested. This work provides significant information about the effect of the studied IL and IL-APIs in elastase enzyme activity.

Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

MedChemComm ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 559 ◽  
Author(s):  
O. Andreea Cojocaru ◽  
Katharina Bica ◽  
Gabriela Gurau ◽  
Asako Narita ◽  
Parker D. McCrary ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Liquid Form ◽  
Pharmaceutical Ingredients

Simultaneous Determination of Emtricitabine and Tenofovir disoproxil fumarate in Pharmaceutical Dosage by Reverse Phase High Performance Liquid Chromatography

2021 ◽  
pp. 412-416
Author(s):  
Rajan V. Rele ◽  
Sandip P. Patil
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Tenofovir Disoproxil Fumarate ◽  
High Performance ◽  
Phosphoric Acid Solution ◽  
Active Pharmaceutical Ingredients ◽  
Chromatography Method ◽  
Pharmaceutical Ingredients

A simple, rapid and accurate high performance liquid chromatography method is described for simultaneous determination of emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients. The separation of drug was achieved on Hypersil BDS C18 (150 x 4.6 mm i.d.) with 5 µ particle size column showed most favorable chromatographic pattern over the other columns. The mobile phase consisted of a mixture of buffer and methanol (85:15 % v/v). The buffer was mixtures of 0.1 % (v/v) ortho-phosphoric acid solution adjusted the pH 3.5 with tri-ethyl amine. The detection was carried out at wavelength 260 nm. The mixture of buffer of pH 3.5 and methanol (85:15% v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients.

scholarly journals Ionic Liquids as Active Pharmaceutical Ingredients

ChemMedChem ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. 975-985 ◽  
Author(s):  
Ricardo Ferraz ◽  
Luís C. Branco ◽  
Cristina Prudêncio ◽  
João Paulo Noronha ◽  
Željko Petrovski
Keyword(s):  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Determination of pKa values of active pharmaceutical ingredients

2007 ◽  
Vol 26 (11) ◽  
pp. 1043-1061 ◽  
Author(s):  
Sandra Babić ◽  
Alka J.M. Horvat ◽  
Dragana Mutavdžić Pavlović ◽  
Marija Kaštelan-Macan
Keyword(s):  
Active Pharmaceutical Ingredients ◽  
Pka Values ◽  
Pharmaceutical Ingredients
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