Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities

RSC Advances ◽  
2016 ◽  
Vol 6 (83) ◽  
pp. 80114-80120 ◽  
Author(s):  
Nina Vaněčková ◽  
Anna Hošt‘álková ◽  
Marcela Šafratová ◽  
Jiří Kuneš ◽  
Daniela Hulcová ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids ◽  
Amaryllidaceae Alkaloids ◽  
Chromatographic Methods

Twenty-two isoquinoline alkaloids (1–22) were isolated from fresh bulbs of Nerine bowdenii (Amaryllidaceae) by standard chromatographic methods.

Isoquinoline Alkaloids fromFumaria officinalisL. and Their Biological Activities Related toAlzheimer's Disease

2016 ◽  
Vol 13 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Jakub Chlebek ◽  
Zdeněk Novák ◽  
Dominika Kassemová ◽  
Marcela Šafratová ◽  
Jan Kostelník ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids

Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities

Heterocycles ◽  
2010 ◽  
Vol 81 (5) ◽  
pp. 1193 ◽  
Author(s):  
Kinuko Iwasa ◽  
Yumi Nishiyama ◽  
Suguru Okada ◽  
Sousuke Takeuchi ◽  
Masataka Moriyasu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids ◽  
Derivatives Of

scholarly journals Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4901
Author(s):  
Seydou Ka ◽  
Manoj Koirala ◽  
Natacha Mérindol ◽  
Isabel Desgagné-Penix
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activities ◽  
Pharmacological Effects ◽  
Amaryllidaceae Alkaloids ◽  
Important Group ◽  
Structure Activity ◽  
Wide Range ◽  
Pharmaceutical Properties

Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

scholarly journals Alkaloids from Peumus boldus and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Inhibition Activity

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Anna Hošt'álková ◽  
Lubomír Opletal ◽  
Jiří Kuneš ◽  
Zdeněk Novák ◽  
Martina Hrabinová ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Inhibition Activity ◽  
Isoquinoline Alkaloids ◽  
Prolyl Oligopeptidase ◽  
Benzylisoquinoline Alkaloids ◽  
Chemical Structures ◽  
Chromatographic Methods ◽  
Ellman’S Method ◽  
Butyrylcholinesterase Inhibition

Eleven isoquinoline alkaloids (1–11) were isolated from dried leaves of Peumus boldus Mol. by standard chromatographic methods. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic analysis, and by comparison with literature data. Compounds isolated in sufficient amount were evaluated for their acetylcholinesterase, and butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro- p-nitroanilide was used as substrate. Promising butyrylcholinesterase inhibition activities were demonstrated by two benzylisoquinoline alkaloids, reticuline (8) and N-methylcoclaurine (9), with IC50 values of 33.6 ± 3.0 μM and 15.0 ± 1.4 μM, respectively. Important prolyl oligopeptidase inhibition activities were shown by N-methyllaurotetanine (6) and sinoacutine (4) with IC50 values of 135.4 ± 23.2 μM and 143.1 ± 25.4 μM, respectively. Other tested compounds were considered inactive.

scholarly journals Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5240
Author(s):  
Lucie Cahlíková ◽  
Rudolf Vrabec ◽  
Filip Pidaný ◽  
Rozálie Peřinová ◽  
Negar Maafi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Life Expectancy ◽  
Neurodegenerative Disease ◽  
Elderly People ◽  
Recent Progress ◽  
Isoquinoline Alkaloids ◽  
Amaryllidaceae Alkaloids ◽  
Age Related

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.

Phytochemical Constituents and Biological Activities of Origanum syriacum

2009 ◽  
Vol 64 (4) ◽  
pp. 447-451 ◽  
Author(s):  
Samy K. El-Desouky ◽  
Lamyaa F. Ibrahim ◽  
Salwa A. Kawashty ◽  
Mohamed A. El-Ansari ◽  
Yeong Suk Kim ◽  
...  
Keyword(s):  
Mtt Assay ◽  
Hela Cells ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Methanol Extract ◽  
Biological Activities ◽  
Flavone Glycoside ◽  
Chromatographic Methods ◽  
Aerial Parts ◽  
Phytochemical Constituents

The cytotoxicity of the methanol extract of Origanum syriacum against human cerivical adenocarcinoma, Hela cells, was evaluated by the MTT assay. From the crude extract, a new flavone glycoside, acacetin-7-O-[2´´-O-α-L-rhamnopyranosyl-6´´-O-β -D-glucopyranosyl]-β -D-glucopyranoside (1), together with the ten known flavonoids luteolin (2), apigenin (3), luteolin-6-C-glucoside (4), luteolin-3´-methylether-6-C-glucoside (5), luteolin-7,4´-dimethyether-6-C-glucoside (6), apigenin-7- methylether-6-C-glucoside (7), apigenin-7-O-glucoside (8), diosmetin-7-O-glucoside (9), acacetin- 7-O-glucoside (10) and acacetin-7-O-rutinoside (11), was isolated from the methanol extract of the aerial parts of Origanum syriacum. The structure elucidation of the isolated compounds was performed by spectroscopic and chromatographic methods.

scholarly journals Recent Progress in Amaryllidaceae Biotechnology

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4670
Author(s):  
Vasil Georgiev ◽  
Ivan Ivanov ◽  
Atanas Pavlov
Keyword(s):  
In Vitro Culture ◽  
Biological Activities ◽  
Plant Secondary Metabolites ◽  
Acetylcholinesterase Activity ◽  
Production Plant ◽  
Biotechnological Production ◽  
Amaryllidaceae Alkaloids ◽  
In Vitro Systems ◽  
Culture Technology

Plants belonging to the monocotyledonous Amaryllidaceae family include about 1100 species divided among 75 genera. They are well known as medicinal and ornamental plants, producing pharmaceutically important alkaloids, the most intensively investigated of which are galanthamine and lycorine. Amaryllidaceae alkaloids possess various biological activities, the most important one being their anti-acetylcholinesterase activity, used for the treatment of Alzheimer’s disease. Due to increased demand for Amaryllidaceae alkaloids (mainly galanthamine) and the limited availability of plant sources, in vitro culture technology has attracted the attention of researchers as a prospective alternative for their sustainable production. Plant in vitro systems have been extensively used for continuous, sustainable, and economically viable production of bioactive plant secondary metabolites. Over the past two decades, a significant success has been demonstrated in the development of in vitro systems synthesizing Amaryllidaceae alkaloids. The present review discusses the state of the art of in vitro Amaryllidaceae alkaloids production, summarizing recently documented plant in vitro systems producing them, as well as the authors’ point of view on the development of biotechnological production processes with a focus on the future prospects of in vitro culture technology for the commercial production of these valuable alkaloids.

scholarly journals Alkaloid Profiling and Cholinesterase Inhibitory Potential of Crinum × amabile Donn. (Amaryllidaceae) Collected in Ecuador

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2686
Author(s):  
Luciana R. Tallini ◽  
Angelo Carrasco ◽  
Karen Acosta León ◽  
Diego Vinueza ◽  
Jaume Bastida ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Biological Activities ◽  
New Drugs ◽  
Bioactive Molecules ◽  
Acetylcholinesterase Inhibition ◽  
Plant Family ◽  
Disease Symptoms ◽  
Amaryllidaceae Alkaloids ◽  
Inhibitory Potential

Natural products are one of the main sources for developing new drugs. The alkaloids obtained from the plant family Amaryllidaceae have interesting structures and biological activities, such as acetylcholinesterase inhibition potential, which is one of the mechanisms used for the palliative treatment of Alzheimer’s disease symptoms. Herein we report the alkaloidal profile of bulbs and leaves extracts of Crinum × amabile collected in Ecuador and their in vitro inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Using Gas Chromatography coupled to Mass Spectrometry (GC-MS), we identified 12 Amaryllidaceae alkaloids out of 19 compounds detected in this species. The extracts from bulbs and leaves showed great inhibitory activity against AChE and BuChE, highlighting the potential of Amaryllidaceae family in the search of bioactive molecules.

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