Isoquinoline Alkaloids fromFumaria officinalisL. and Their Biological Activities Related toAlzheimer's Disease

2016 ◽  
Vol 13 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Jakub Chlebek ◽  
Zdeněk Novák ◽  
Dominika Kassemová ◽  
Marcela Šafratová ◽  
Jan Kostelník ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids

Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities

Heterocycles ◽  
2010 ◽  
Vol 81 (5) ◽  
pp. 1193 ◽  
Author(s):  
Kinuko Iwasa ◽  
Yumi Nishiyama ◽  
Suguru Okada ◽  
Sousuke Takeuchi ◽  
Masataka Moriyasu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids ◽  
Derivatives Of

Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities

RSC Advances ◽  
2016 ◽  
Vol 6 (83) ◽  
pp. 80114-80120 ◽  
Author(s):  
Nina Vaněčková ◽  
Anna Hošt‘álková ◽  
Marcela Šafratová ◽  
Jiří Kuneš ◽  
Daniela Hulcová ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids ◽  
Amaryllidaceae Alkaloids ◽  
Chromatographic Methods

Twenty-two isoquinoline alkaloids (1–22) were isolated from fresh bulbs of Nerine bowdenii (Amaryllidaceae) by standard chromatographic methods.

Synthesis of 2-(2-hydroxyethyl)-1-(2-hydroxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and pseudosymmetry in its crystal structure

2016 ◽  
Vol 72 (8) ◽  
pp. 607-611 ◽  
Author(s):  
Kambarali K. Turgunov ◽  
Sherzod N. Zhurakulov ◽  
Ulli Englert ◽  
Valentina I. Vinogradova ◽  
Bakhodir Tashkhodjaev
Keyword(s):  
Structural Model ◽  
Biological Activities ◽  
Molecular Geometry ◽  
Intramolecular Hydrogen Bonding ◽  
Asymmetric Unit ◽  
Isoquinoline Alkaloids ◽  
Title 1 ◽  
Anisotropic Displacement Parameters ◽  
Intramolecular Hydrogen ◽  
Hydroxyethyl Group

Natural and synthetic isoquinoline alkaloids display a wide variety of potent biological activities. The title 1-aryl-2-hydroxyethyl-1,2,3,4-tetrahydroisoquinoline, C19H23NO4, crystallizes with two molecules in the asymmetric unit related by pseudo-translation but differing only slightly in conformation. The pseudosymmetry is also reflected in the diffraction pattern. The subset of reflections corresponding to the smaller cell and average structure are on average twice as intense as those subtending the larger cell. Tentative refinement in the subcell leads to a disordered structural model with satisfactory agreement factors and, after appropriate use of restraints, acceptable molecular geometry but significantly larger and more anisotropic displacement parameters. In the correct unit cell, the independent molecules differ with respect to the orientation of the hydroxyethyl group. Intramolecular hydrogen bonding occurs between the hydroxyphenyl group and the N atom.

scholarly journals Genomic and Chemical Investigation of Bioactive Secondary Metabolites From a Marine-Derived Fungus Penicillium steckii P2648

2021 ◽  
Vol 12 ◽  
Author(s):  
Guangshan Yao ◽  
Xiaofeng Chen ◽  
Huawei Zheng ◽  
Danhua Liao ◽  
Zhi Yu ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Gene Cluster ◽  
Pathogenic Bacteria ◽  
Biological Activities ◽  
Gene Clusters ◽  
Ionization Mass ◽  
Structural Determination ◽  
Isoquinoline Alkaloids ◽  
Biosynthesis Gene Cluster ◽  
Strong Activity

Marine fungi of the genus Penicillium are rich resources of secondary metabolites, showing a variety of biological activities. Our anti-bacterial screening revealed that the crude extract from a coral-derived fungus Penicillium steckii P2648 showed strong activity against some pathogenic bacteria. Genome sequencing and mining uncovered that there are 28 secondary metabolite gene clusters in P2648, potentially involved in the biosynthesis of antibacterial compounds. Chemical isolation and structural determination suggested citrinin is the dominant component of the crude extracts of P2648, and our further tests confirmed that citrinin showed excellent activities against various pathogenic bacteria. Moreover, the gene cluster containing a homolog of the polyketide synthase CitS was identified as the citrinin biosynthesis gene cluster through genetic analysis. Interestingly, three isoquinoline alkaloids were unexpectedly activated and isolated from the Δcits mutant and structural determination by using high-resolution electron spray ionization mass spectroscopy (HRESIMS), 1D, and 2D NMR. Further antibacterial assays displayed that compounds 1 and 2, but not compound 3, showed moderate activities against two antibiotic-resistant pathogenic bacteria with minimum inhibitory concentration (MIC) of 16–32 μg/ml. In conclusion, our results demonstrated that citrinin and isoquinoline alkaloids represent as the major antibacterial agents in the coral-associated fungus P. steckii P2648, and our genomic and chemical analyses present evidence in support of P. steckii P2648 as a potent natural products source for anti-bacterial drug discovery.

Two new isoquinoline alkaloids from Cryptocarya wrayi and their biological activities

Fitoterapia ◽  
2021 ◽  
pp. 105086
Author(s):  
Yun-Lai Liu ◽  
Yong Wang ◽  
Xiao-Ru He ◽  
Li-She Gan ◽  
Fan Xu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Isoquinoline Alkaloids

Improvement of cytoprotective and antioxidant activity of Rosa canina L. and Salix alba L. by controlled differential sieving process against H2O2-induced oxidative stress in mouse primary splenocytes

2017 ◽  
Vol 87 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
Nidhal Soualeh ◽  
Aliçia Stiévenard ◽  
Elie Baudelaire ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Good Alternative ◽  
Activity Levels ◽  
Salix Alba ◽  
Rosa Canina ◽  
Free Process ◽  
Plant Powders ◽  
Sieving Process

Abstract. In this study, cytoprotective and antioxidant activities of Rosa canina (RC) and Salix alba (SA), medicinal plants, were studied on mouse primary splenocytes by comparing Controlled Differential Sieving process (CDSp), which is a novel green solvent-free process, versus a conventional technique, employing hydroethanolic extraction (HEE). Thus, preventive antioxidant activity of three plant powders of homogeneous particle sizes, 50–100 µm, 100–180 µm and 180–315 µm, dissolved directly in the cellular buffer, were compared to those of hydroethanolic (HE) extract, at 2 concentrations (250 and 500 µg/mL) in H2O2-treated spleen cells. Overall, compared to HE extract, the superfine powders, i. e., fractions < 180 µm, at the lowest concentration, resulted in greater reactive oxygen species (ROS) elimination, increased glutathione peroxidase (GPx) activity and lower malondialdehyde (MDA) production. Better antioxidant and preventive effects in pre-treated cells were found with the superfine powders for SA (i. e., 50–100 µm and 100–180 µm, both p < 0.001), and with the intermediate powder for RC (i. e., 100–180 µm, p < 0.05) versus HE extract. The activity levels of catalase (CAT) and superoxide dismutase (SOD) in pretreated splenocytes exposed to H2O2, albeit reduced, were near to those in unexposed cells, suggesting that pretreatment with the fine powders has relatively restored the normal levels of antioxidant-related enzymes. These findings supported that CDSp improved the biological activities of plants, avoiding the use of organic solvents and thus it could be a good alternative to conventional extraction techniques.

Shape‐controlled silver NPs for shape‐dependent biological activities

2017 ◽  
Vol 12 (9) ◽  
pp. 647-651 ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Abolfazl Yazdanpanah ◽  
Amirbabak Abrishamkar ◽  
Fatholah Moztarzadeh ◽  
Arash Ramedani ◽  
...  
Keyword(s):  
Biological Activities ◽  
Silver Nps ◽  
Shape Controlled

Research into chemistry and biological activities of Prangos Lindl. (Apiaceae) species of Turkey

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
KHC Baser ◽  
B Demirci ◽  
G Ozek ◽  
A Duran ◽  
N Tabanca ◽  
...  
Keyword(s):  
Biological Activities
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