Two-stage pH-sensitive doxorubicin hydrochloride loaded core–shell nanoparticles with dual drug-loading strategies for the potential anti-tumor treatment

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104049-104066 ◽  
Author(s):  
Xiaoyue Yu ◽  
Bo Zhang ◽  
Tianqi Wang ◽  
Jing Zhang ◽  
Shengjun Mu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Core Shell ◽  
Doxorubicin Hydrochloride ◽  
Tumor Treatment ◽  
Two Stage ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Dual Drug

Two-stage pH-sensitive DOX·HCl loaded core–shell nanoparticles (CPOD) with dual drug-loading strategies showed pretty in vivo anti-tumor efficacy.

scholarly journals Thrombolysis Combined Therapy Using CuS@SiO2-PEG/uPA Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Dapeng Fu ◽  
Qingbo Fang ◽  
Fukang Yuan ◽  
Junle Liu ◽  
Heyi Ding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Combined Therapy ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Massive hemorrhage caused by the uncontrolled release of thrombolysis drugs is a key issue of thrombolysis therapy in clinical practice. In this study, we report a near-infrared (NIR) light-triggered drug delivery system, i.e., CuS@mSiO2-PEG (CSP) nanoparticles, for the loading of a thrombolytic drug (urokinase plasminogen activators, uPA). CSP nanoparticles with the CuS nanoparticles as photothermal agents and mesoporous SiO2 for the loading of uPA were synthesized using a facile hydrothermal method. The CSP core-shell nanoparticles were demonstrated to possess excellent photothermal performance, exhibiting a photothermal conversion efficiency of up to 52.8%. Due to the mesoporous SiO2 coating, the CSP core-shell nanoparticles exhibited appropriate pore size, high pore volume, and large surface area; thus, they showed great potential to be used as drug carriers. Importantly, the release of uPA from CuS@mSiO2-PEG/uPA (CSPA) carriers can be promoted by the NIR laser irradiation. The drug loading content of uPA for the as-prepared NIR-triggered drug delivery system was calculated to be 8.2%, and the loading efficiency can be determined to be as high as 89.6%. Due to the excellent photothermal effect of CSP nanocarriers, the NIR-triggered drug delivery system can be used for infrared thermal imaging in vivo. The in vivo thrombolysis assessment demonstrated that the NIR-triggered drug delivery system showed excellent thrombolytic ability under the irradiation of an 808 nm laser, showing the combined therapy for thrombolysis. As far as we know, the CSPA core-shell nanoparticles used as NIR-triggered drug delivery systems for thrombolysis have not been reported.

scholarly journals Dye-doped biodegradable nanoparticle SiO2 coating on zinc- and iron-oxide nanoparticles to improve biocompatibility and for in vivo imaging studies

Nanoscale ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 6164-6175 ◽  
Author(s):  
Elena Navarro-Palomares ◽  
Paula González-Saiz ◽  
Carlos Renero-Lecuna ◽  
Rosa Martín-Rodríguez ◽  
Fernando Aguado ◽  
...  
Keyword(s):  
Iron Oxide ◽  
In Vivo Imaging ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Imaging Studies ◽  
Sio2 Coating ◽  
Shell Nanoparticles ◽  
Nano Medicine ◽  
Core Shell Nanoparticles

Core–shell nanoparticles provide two fold functionality in nano medicine: reduction of nanotoxicity and improving as a tool for imaging and therapy.

Self-assembled dual-drug loaded core-shell nanoparticles based on metal-free fully alternating polyester for cancer theranostics

2019 ◽  
Vol 101 ◽  
pp. 448-463 ◽  
Author(s):  
Piyush Kumar Gupta ◽  
Sreenath Pappuru ◽  
Santosh Gupta ◽  
Bamadeb Patra ◽  
Debashis Chakraborty ◽  
...  
Keyword(s):  
Core Shell ◽  
Shell Nanoparticles ◽  
Metal Free ◽  
Self Assembled ◽  
Cancer Theranostics ◽  
Core Shell Nanoparticles ◽  
Dual Drug

Two-Stage Melting in Core–Shell Nanoparticles: An Atomic-Scale Perspective

2012 ◽  
Vol 116 (21) ◽  
pp. 11837-11841 ◽  
Author(s):  
Rao Huang ◽  
Yu-Hua Wen ◽  
Zi-Zhong Zhu ◽  
Shi-Gang Sun
Keyword(s):  
Atomic Scale ◽  
Core Shell ◽  
Two Stage ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery

2015 ◽  
Vol 72 ◽  
pp. 640-648 ◽  
Author(s):  
Piyasi Mukhopadhyay ◽  
Souma Chakraborty ◽  
Sourav Bhattacharya ◽  
Roshnara Mishra ◽  
P.P. Kundu
Keyword(s):  
Insulin Delivery ◽  
Ph Sensitive ◽  
Core Shell ◽  
Oral Insulin ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Catalytic Core-Shell Nanoparticles With Self-Supplied Calcium And H2O2 To Enable Combinational Tumor Inhibition

2021 ◽  
Author(s):  
Chao Fang ◽  
Hanjing Kong ◽  
Qiang Chu ◽  
Zefeng Hu ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Shell Nanoparticles ◽  
Catalytic Core ◽  
Tumor Inhibition ◽  
Fenton Catalyst ◽  
Core Shell Nanoparticles

Abstract Nanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited intracellular H2O2 and thus suppressed therapeutic efficacy. Here in this study, a type of composite nanoparticles, consisting CaO2 core and Co-ferrocene shell, is designed and synthesized for combinational tumor treatment. The findings indicate that CaO2 core can be hydrolyzed to produce large amounts of H2O2 and calcium ions at the acidic tumor sites. Meanwhile, Co-ferrocene shell acts as an excellent Fenton catalyst, inducing considerable ROS generation following its reaction with H2O2. Excessive cellular oxidative stress triggers agitated calcium accumulation in addition to the calcium ions released from the particles. The combined effect of intracellular ROS and calcium overload causes significant tumor inhibition both in vitro and in vivo.

scholarly journals Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2790
Author(s):  
Gracia García-García ◽  
Fátima Fernández-Álvarez ◽  
Laura Cabeza ◽  
Ángel V. Delgado ◽  
Consolación Melguizo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Loading ◽  
Production Performance ◽  
Solid Matrix ◽  
Complete Analysis ◽  
Core Shell ◽  
Hysteresis Cycle ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Core Shell Nanoparticles

A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values (≈11%), and a biphasic and pH-responsive drug release profile (≈four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was ≈two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment.

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