scholarly journals Tuning Crystal Structures of Iron-Based Metal–Organic Frameworks for Drug Delivery Applications

ACS Omega ◽  
2020 ◽  
Vol 5 (7) ◽  
pp. 3418-3427 ◽  
Author(s):  
Hao Pham ◽  
Kimberly Ramos ◽  
Andy Sua ◽  
Jessica Acuna ◽  
Katarzyna Slowinska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crystal Structures ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based ◽  
Drug Delivery Applications

Diffusion as a function of guest molecule length and functionalization in flexible metal–organic frameworks

2016 ◽  
Vol 3 (4) ◽  
pp. 355-361 ◽  
Author(s):  
B. Zheng ◽  
L. L. Wang ◽  
L. Du ◽  
Y. Pan ◽  
Z. Lai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Guest Molecule ◽  
Metal Organic Frameworks ◽  
Chemical Separation ◽  
Efficient Design ◽  
Metal Organic ◽  
Drug Delivery Applications ◽  
Flexible Metal

Understanding guest diffusion in nanoporous host–guest systems is crucial in the efficient design of metal–organic frameworks (MOFs) for chemical separation and drug delivery applications.

Nanoscale iron carboxylate metal organic frameworks as drug carriers for magnetically aided intracellular delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76861-76866 ◽  
Author(s):  
Komal Sethi ◽  
Shalini Sharma ◽  
Indrajit Roy
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Intracellular Delivery ◽  
Drug Carriers ◽  
Metal Organic ◽  
Drug Delivery Applications ◽  
Iron Carboxylate

We report the synthesis, characterisation, and magnetically controlled drug delivery applications of drug-encapsulated iron carboxylate nanoscale metal organic frameworks (NMOFs).

Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks

2020 ◽  
Vol 16 (9) ◽  
pp. 1359-1369
Author(s):  
Mihad Ibrahim ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini ◽  
Abdollah Karami ◽  
Reenu Geetha Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Encapsulation Efficiency ◽  
Metal Organic Frameworks ◽  
In Vitro Release ◽  
Triggered Release ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
Iron Based

Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF nanovehicles, and their mechanism is poorly understood. In this work, newly developed iron-based MOFs, namely Fe-NDC nanorods, were investigated as potential nanocarriers for calcein (as a model drug/dye) and Doxorubicin (a chemotherapeutic drug (DOX)). Calcein was successfully loaded by equilibrating its solution with the MOFs nanoparticles under constant stirring. The calcein average encapsulation efficiency achieved was 43.13%, with a corresponding capacity of 17.74 wt.%. In-vitro calcein release was then carried out at 37°C in phosphate buffer saline (PBS) using ultrasound (US) as an external trigger. MOFs released an average of 17.8% (without US), whereas they released up to 95.2% of their contents when 40-kHz US at ~1 W/cm2 was applied for 10 min. The Cytotoxic drug DOX was also encapsulated in Fe-NDC, and its In-vitro release profile was determined under the same conditions. DOX encapsulation efficiency and capacity were found to be 16.10% and 13.37 wt.%, respectively. In-vitro release experiments demonstrated significant release, reaching 80% in 245 minutes, under acoustic irradiation, compared to around 6% in the absence of US. Additionally, experimental results showed that Fe-NDC nanoparticles are biocompatible even at relatively high concentrations, with an MCF-7 IC50 of 1022 g/ml. Our work provides a promising platform for anticancer drug delivery by utilizing biocompatible Fe-NDC nanoparticles and US as an external trigger mechanism.

Iron-Based Metal–Organic Frameworks in Drug Delivery and Biomedicine

2021 ◽  
Vol 13 (8) ◽  
pp. 9643-9655
Author(s):  
Xianbin Liu ◽  
Tiantian Liang ◽  
Rongtao Zhang ◽  
Qian Ding ◽  
Siqiong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Water-stable zirconium and iron-based metal-organic frameworks (MOFs) as fluoride scavengers in aqueous medium

2021 ◽  
Vol 270 ◽  
pp. 118645
Author(s):  
Mohammad Hossien Saghi ◽  
Bruno Chabot ◽  
Shahabaldin Rezania ◽  
Mika Sillanpää ◽  
Ali Akbar Mohammadi ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based

Biomimetic Catalysts of Iron–based Metal-Organic Frameworks with High Peroxidase-Mimicking Activity for Colorimetric Biosensing

2021 ◽  
Author(s):  
Xiao-Ning Wang ◽  
Yu-Meng Zhao ◽  
Jialuo Li ◽  
Jiandong Pang ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Systematic Investigation ◽  
Biomimetic Catalysts ◽  
Biomimetic Catalyst ◽  
Metal Organic ◽  
Iron Based ◽  
Colorimetric Biosensing

The field of Metal-Organic Frameworks (MOFs)-based biomimetic catalyst has achieved great progresses, but is still in its infancy stage. The systematic investigation on the tailored construction of MOF-based biomimetic catalysts...

Negative linear compressibility in nanoporous metal-organic frameworks rationalized by the empty channel structural mechanism

2021 ◽  
Author(s):  
Francisco Colmenero
Keyword(s):  
Crystal Structures ◽  
Metal Organic Frameworks ◽  
Structural Mechanism ◽  
Nanoporous Metal ◽  
Metal Organic ◽  
Linear Compressibility

Cobalt squarate hydroxide (Co3(C4O4)2(OH)2), zinc squarate tetrahydrate (ZnC4O4·4 H2O) and titanium oxalate trioxide dihydrate (Ti2(C2O4)O3·2 H2O) are nanoporous metal-organic frameworks possessing empty channels in their crystal structures. The crystal structures...

Sign in / Sign up

Export Citation Format

Share Document