scholarly journals Synthesis and analysis of stable isotope-labelled N-acyl homoserine lactones

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73717-73730 ◽  
Author(s):  
Ewout Ruysbergh ◽  
Christian V. Stevens ◽  
Norbert De Kimpe ◽  
Sven Mangelinckx
Keyword(s):  
Stable Isotope ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Deuterated Standards

An easy, reliable manner to make suitable, deuterated standards of AHL-molecules belonging to all three important classes of AHLs is presented, starting from a cheap and commercially available deuterium source.

scholarly journals Human Paraoxonase-2 (PON2): Protein Functions and Modulation

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 256
Author(s):  
Giuseppe Manco ◽  
Elena Porzio ◽  
Teresa Maria Carusone
Keyword(s):  
Hydrolytic Activity ◽  
Principal Function ◽  
Substrate Specificities ◽  
Homoserine Lactones ◽  
Stress Control ◽  
Acyl Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Protein Functions ◽  
Bacterial Quorum ◽  
Hydrolyzing Enzymes

PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity toward many acyl-homoserine lactones (acyl-HL) involved in bacterial quorum-sensing signaling. Accordingly, defense against pathogens, such as Brevundimonas aeruginosa (B. aeruginosa), was postulated to be the principal function of PON2. However, recent findings have highlighted the importance of PON2 in oxidative stress control, inhibition of apoptosis, and the progression of various types of malignancies. This review focuses on all of these aspects of PON2.

scholarly journals Sampling, separation, and quantification of N ‐acyl homoserine lactones from marine intertidal sediments

2021 ◽  
Vol 19 (2) ◽  
pp. 145-157
Author(s):  
Frederike Stock ◽  
Emilio Cirri ◽  
Samarasinghe Gunasekara Liyanage Is Nuwanthi ◽  
Willem Stock ◽  
Nico Ueberschaar ◽  
...  
Keyword(s):  
Intertidal Sediments ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones
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