Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64239-64246 ◽  
Author(s):  
Marin Simeonov ◽  
Bistra Kostova ◽  
Elena Vassileva

Novel interpenetrating polymer networks (IPN) of poly(methacrylic acid) (PMAA) and polyacrylamide (PAAm) were synthesized and characterized and their potential as drug delivery system was revealed.

Author(s):  
Maryam Bakhshizadeh ◽  
Ameneh Sazgarnia ◽  
Mahmoud Seifi ◽  
Farzin Hadizadeh ◽  
Ghadir Rajabzadeh ◽  
...  

2019 ◽  
Vol 64 (No. 7) ◽  
pp. 287-293
Author(s):  
J Matejkova ◽  
P Podhorec

Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.


RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.


1985 ◽  
Vol 74 (9) ◽  
pp. 922-925 ◽  
Author(s):  
Alan L. Weiner ◽  
Sharon S. Carpenter-Green ◽  
Ellen C. Soehngen ◽  
Robert P. Lenk ◽  
Mircea C. Popescu

2009 ◽  
Vol 21 (13) ◽  
pp. 2679-2687 ◽  
Author(s):  
Sylvie Bégu ◽  
Anne Aubert-Pouëssel ◽  
Ramona Polexe ◽  
Eliska Leitmanova ◽  
Dan A. Lerner ◽  
...  

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