Effect of arginine : lysine ratio in free amino acid and protein form onl-NAME induced hypertension in hypercholesterolemic Wistar rats

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73388-73398 ◽  
Author(s):  
Vishwanath S. Vallabha ◽  
Arun Tapal ◽  
Shinde Vijay Sukhdeo ◽  
Govindaraju K ◽  
Purnima Kaul Tiku
Keyword(s):  
Free Amino ◽  
Wistar Rats ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin System ◽  
Angiotensin I Converting Enzyme ◽  
Oxide Precursor ◽  
System P ◽  
Induced Hypertension

Arginine : lysine in the ratio of 5 : 1 plays an important role in cardiovascular diseases, especially as a nitric oxide precursor leading to vasodilation and inhibiting angiotensin-I converting enzyme in renin angiotensin system.

scholarly journals Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Author(s):  
Dong Chen ◽  
Xiaokun Li ◽  
Qifa Song ◽  
Chenchan Hu ◽  
Feifei Su ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Renin Angiotensin System ◽  
Good Prognosis ◽  
Clinical Implications ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin System ◽  
Angiotensin I Converting Enzyme ◽  
Underlying Causes ◽  
The Relationship

BACKGROUNDSARS-CoV-2 has caused a series of COVID-19 globally. SARS-CoV-2 binds angiotensin I converting enzyme 2 (ACE2) of renin–angiotensin system (RAS) and causes prevalent hypokalemiaMETHODSThe patients with COVID-19 were classified into severe hypokalemia, hypokalemia, and normokalemia group. The study aimed to determine the relationship between hypokalemia and clinical features, the underlying causes and clinical implications of hypokalemia.RESULTSBy Feb 15, 2020, 175 patients with COVID-19 (92 women and 83 men; median age, 46 [IQR, 34–54] years) were admitted to hospital in Wenzhou, China, consisting 39 severe hypokalemia-, 69 hypokalemia-, and 67 normokalemia patients. Gastrointestinal symptoms were not associated with hypokalemia among 108 hypokalemia patients (P > 0.05). Body temperature, CK, CK-MB, LDH, and CRP were significantly associated with the severity of hypokalemia (P<0.01). 93% of severe and critically ill patients had hypokalemia which was most common among elevated CK, CK-MB, LDH, and CRP. Urine K+ loss was the primary cause of hypokalemia. 1 severe hypokalemia patients was given 3 g/day, adding up to an average of 34 (SD=4) g potassium during hospital stay. The exciting finding was that patients responded well to K+ supplements when they were inclined to recovery.CONCLUSIONSHypokalemia is prevailing in patients with COVID-19. The correction of hypokalemia is challenging because of continuous renal K+ loss resulting from the degradation of ACE2. The end of urine K+ loss indicates a good prognosis and may be a reliable, in-time, and sensitive biomarker directly reflecting the end of adverse effect on RAS system.

scholarly journals Garlic Attenuates Plasma and Kidney ACE-1 and AngII Modulations in Early Streptozotocin-Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Khaled K. Al-Qattan ◽  
Martha Thomson ◽  
Divya Jayasree ◽  
Muslim Ali
Keyword(s):  
Blood Pressure ◽  
Renal Clearance ◽  
Renin Angiotensin System ◽  
Diabetic Rats ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin System ◽  
Angiotensin I Converting Enzyme ◽  
Type 1 Dm

Raw garlic aqueous extract (GE) has ameliorative actions on the renin-angiotensin system in type-1 diabetes mellitus (DM); however its effects on plasma and kidney angiotensin I converting enzyme type-1 (ACE-1) and angiotensin II (AngII) require further elucidation. This study investigated the effect of GE on plasma and kidney ACE-1 and AngII concentrations and in relation to systemic and renal clearance indicators significant to blood pressure (BP) homeostasis in early streptozotocin- (STZ-) induced type-1 DM. Normal rats (n=10) received 0.5 mL normal saline (NR/NS), diabetic rats (n=10) received 0.5 mL NS (DR/NS), and treated diabetic rats (n=10) received 50 mg/0.1 mL/100 g body weight GE (DR/GE) as daily intraperitoneal injections for 8 weeks. Compared to NR/NS, DR/NS showed a significant increase in plasma ACE-1 and AngII and conversely a decrease in kidney ACE-1 and AngII. These changes were associated with an increase in BP and clearance functions. Alternatively and compared to DR/NS, DR/GE showed normalization or attenuation in plasma and kidney ACE-1 and AngII. These GE induced rectifications were associated with moderation in BP elevation and renal clearance functions. Garlic attenuates modulations in plasma and kidney ACE-1 and AngII, in addition to BP and renal clearance function in type-1 DM.

Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer

Cancer ◽  
2008 ◽  
Vol 112 (4) ◽  
pp. 748-757 ◽  
Author(s):  
Ronald van der Knaap ◽  
Claire Siemes ◽  
Jan-Willem W. Coebergh ◽  
Cornelia M. van Duijn ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Deletion Polymorphism ◽  
Angiotensin System ◽  
Enzyme Gene ◽  
Renin Angiotensin ◽  
Gene Insertion ◽  
Angiotensin I Converting Enzyme

scholarly journals Nandrolone increases angiotensin-I converting enzyme activity in rats tendons

2015 ◽  
Vol 21 (3) ◽  
pp. 173-177 ◽  
Author(s):  
Rita de Cassia Marqueti ◽  
Nara Yumi Hashimoto ◽  
João Luiz Quaglioti Durigan ◽  
Lívia Larissa Batista e Silva ◽  
Jeeser Alves de Almeida ◽  
...  
Keyword(s):  
Training Session ◽  
Renin Angiotensin System ◽  
Tissue Growth ◽  
Control Group ◽  
Activity Levels ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme ◽  
Tendon Adaptation ◽  
Ace Activity

INTRODUCTION: The renin-angiotensin system (RAS) has been associated with several biological processes of the human body, regulating, among others blood pressure and water and electrolytes balance. Moreover, RAS also regulates connective tissue growth. Recently, studies have shown that the use of nandrolone modifies the angiotensin-I converting enzyme (ACE) activity and increases collagen deposition in the heart. OBJECTIVE: The aim of study was to evaluate the Angiotensin-I converting enzyme (ACE) activity in the superficial flexor tendon (SFT) and in serum after load exercise in combination with anabolic androgenic steroid (AAS) administration after training session and six weeks of detraining. METHODS: Forty-eight Wistar rats were used into two groups (G1 and G2) subdivided into four subgroups: Sedentary (S); trained (T); AAS-treated (Deca-Durabolin(r), 5mg/kg, twice a week) sedentary rats (AAS) and AAS-treated and trained animals (AAST). Trained groups performed jumps in water: four series of 10 jumps each, followed by a 30 sec interval between the series, for seven weeks. RESULTS: Training increased ACE activity in the SFT compared to the control group (p <0.05). Both AAS and AAST groups presented higher ACE activity levels (p < 0.05). The AAST increased the ACE activity only compared to the trained animals. Only the AAST group presented significant higher levels of ACE in the serum. In the G2 group, all experimental groups presented decreased ACE activity in the serum and in the tendon, as compared to the control group. CONCLUSION: This study indicates that AAS administration and its combination with exercise increased ACE activity of tendons. AAS abuse could compromise tendon adaptation causing maladaptive remodeling.

scholarly journals Differences in the expression of the renin angiotensin system and the kallikrein-kinin system during the course of myocardial infarction in male and female Wistar rats

2020 ◽  
Vol 21 (2) ◽  
pp. 147032031990003
Author(s):  
Jazmín Flores-Monroy ◽  
Diego Lezama-Martínez ◽  
Salvador Fonseca-Coronado ◽  
Luisa Martínez-Aguilar
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Converting Enzyme ◽  
Wistar Rats ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Kinin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Female Wistar Rats ◽  
Kallikrein Kinin System

Background: There is some evidence that components of the renin-angiotensin system and kallikrein-kinin system are not similarly regulated in both sexes. The aim of this work was to analyze the expression of angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin 1 receptor, angiotensin 2 receptor, beta-1 receptor, and beta-2 receptor during the evolution of myocardial infarction. Methods: Thirty-six male and 36 female Wistar rats were used. Myocardial infarction was induced. Six groups of both sexes were formed, ( n=6): (a) sham; (b) 48 h myocardial infarction; (c) one week myocardial infarction; (d) two weeks myocardial infarction; (e) three weeks myocardial infarction and (f) four weeks myocardial infarction. The expression was evaluated by real-time polymerase chain reaction on the penumbra of left ventricle. Results: The mRNA expression of most biomarkers was lower in females than in males. During acute infarction, an increase of all protein expression was found in female and at two weeks while in the male only biomarker changes occurred at three weeks. In addition, in male biomarkers mRNA expression decreased during chronic infarction while in females it did not. Conclusions: The renin-angiotensin system and kallikrein-kinin system biomarkers expression occurs at earlier times in the female than in the male rat. In addition, during chronic myocardial infarction these biomarkers remained unchanged in females while in males they decreased.

ACE2–angiotensin-(1–7)–Mas axis in renal ischaemia/reperfusion injury in rats

2010 ◽  
Vol 119 (9) ◽  
pp. 385-394 ◽  
Author(s):  
Kátia D. da Silveira ◽  
Kênia S. Pompermayer Bosco ◽  
Lúcio R. L. Diniz ◽  
Adriana K. Carmona ◽  
Giovanni D. Cassali ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Renin Angiotensin System ◽  
At1 Receptor ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Ischaemia Reperfusion Injury ◽  
Mas Receptor ◽  
Angiotensin I Converting Enzyme ◽  
Ischaemia Reperfusion ◽  
Renal Expression

AngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor also play a role in renal disease models. Therefore, in the present study, we have examined the renal profile of Ang-(1–7), ACE2 and the Mas receptor in renal I/R and compared them with that of AngII, ACE and the AT1 receptor. Male Wistar rats were submitted to left nephrectomy and ischaemia (45 min) followed by reperfusion (2 or 4 h) in the right kidney. At 4 h of reperfusion, renal AngII was increased (P<0.01) and renal Ang-(1–7) was decreased substantially (P<0.05), although plasma levels of both angiotensins were unchanged. In addition, renal I/R decreased the renal mRNA expression of renin (P<0.05), AT1 receptors (P<0.001) and ACE2 (P<0.05). At 2 and 4 h of reperfusion, renal ACE activity was reduced (P<0.05). On the other hand, renal expression of the Mas receptor was greatly increased at 4 h of reperfusion (P<0.01), which was confirmed by immunohistochemical and Western blot analysis. In conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin–angiotensin system)-related peptidases support an important role for the ACE2–Ang-(1–7)–Mas axis in AKI.

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