Cu(i)-catalyzed multicomponent cascade reactions of terminal alkynes, unactivated primary alkyl bromides, CO2 and NaN3

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63855-63858 ◽  
Author(s):  
Fu-song Wu ◽  
Wei Tong ◽  
Ying Liang ◽  
Heng-shan Wang ◽  
Qing-hu Teng ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Sodium Azide ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Terminal Alkynes ◽  
Alkyl Bromides

We have developed a mild, robust, and multicomponent cascade reaction for the synthesis of triazolo-fused dihydrooxazinones from terminal alkynes, unactivated primary alkyl bromides, carbon dioxide and sodium azide.

ChemInform Abstract: Cu(I)-Catalyzed Multicomponent Cascade Reactions of Terminal Alkynes, Unactivated Primary Alkyl Bromides, CO2and NaN3.

ChemInform ◽  
2016 ◽  
Vol 47 (47) ◽  
Author(s):  
Fu-song Wu ◽  
Wei Tong ◽  
Ying Liang ◽  
Heng-shan Wang ◽  
Qing-hu Teng ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Terminal Alkynes ◽  
Alkyl Bromides

Efficient Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Ligand‐Free Copper Catalyst under Ambient Conditions

2019 ◽  
Vol 8 (8) ◽  
pp. 1501-1505 ◽  
Author(s):  
Wan‐Hui Wang ◽  
Lihong Jia ◽  
Xiujuan Feng ◽  
Dingqiao Fang ◽  
Hongyu Guo ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Copper Catalyst ◽  
Terminal Alkynes ◽  
Ambient Conditions ◽  
Ligand Free

A method for estimation of urea using ammonia electrode and its applicability to milk samples

2008 ◽  
Vol 75 (4) ◽  
pp. 466-470 ◽  
Author(s):  
Rajan Sharma ◽  
Yudhishthir S Rajput ◽  
Sumandeep Kaur ◽  
Sudhir K Tomar
Keyword(s):  
Carbon Dioxide ◽  
Sodium Azide ◽  
Inverse Relationship ◽  
Ammonium Ion ◽  
Enzymatic Method ◽  
Alkaline Ph ◽  
Milk Samples ◽  
Electrode Response ◽  
Urease Enzyme ◽  
Ammonia Electrode

A method for the estimation of urea in milk using ammonia electrode is described. Urea is first degraded by urease enzyme into ammonium ion and carbon dioxide at neutral pH. The ammonium ion is then converted into ammonia at alkaline pH. A linear inverse relationship was observed between logarithmic concentration of ammonia or urea and electrode response. Repeatability, expressed as a coefficient of variation, was 1·77% at a level of 8·92 mm-urea in milk. The method was validated in milk samples spiked with between 2×10−3 and 10×10−3 m-urea and recovery of added urea was quantitative. Whereas, preservative sodium azide at 0·5 g/l or 2 g/l level did not affect results, lower values of urea concentration in presence of Bronopol at 0·5 g/l were observed. Urea levels in milk samples estimated by this method were comparable to standard enzymatic method. The method is simple, fast and is not prone to interference from other milk constituents.

scholarly journals Synthesis of a Novel Series of Cu(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Homogeneous and Carbon-Supported Catalysts for the Synthesis of 1- and 2-Substituted-1,2,3-triazoles

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2702
Author(s):  
Ivy L. Librando ◽  
Abdallah G. Mahmoud ◽  
Sónia A. C. Carabineiro ◽  
M. Fátima C. Guedes da Silva ◽  
Carlos F. G. C. Geraldes ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Sodium Azide ◽  
Supported Catalysts ◽  
Cycloaddition Reaction ◽  
Water Soluble ◽  
Terminal Alkynes ◽  
One Pot ◽  
Catalytic Systems ◽  
Immobilized Catalyst ◽  
High Yields

The N-alkylation of 1,3,5-triaza-7-phosphaadamantane (PTA) with ortho-, meta- and para-substituted nitrobenzyl bromide under mild conditions afforded three hydrophilic PTA ammonium salts, which were used to obtain a new set of seven water-soluble copper(I) complexes. The new compounds were fully characterized and their catalytic activity was investigated for the low power microwave assisted one-pot azide–alkyne cycloaddition reaction in homogeneous aqueous medium to obtain disubstituted 1,2,3-triazoles. The most active catalysts were immobilized on activated carbon (AC), multi-walled carbon nanotubes (CNT), as well as surface functionalized AC and CNT, with the most efficient support being the CNT treated with nitric acid and NaOH. In the presence of the immobilized catalyst, several 1,4-disubstituted-1,2,3-triazoles were obtained from the reaction of terminal alkynes, organic halides and sodium azide in moderate yields up to 80%. Furthermore, the catalyzed reaction of terminal alkynes, formaldehyde and sodium azide afforded 2-hydroxymethyl-2H-1,2,3-triazoles in high yields up to 99%. The immobilized catalyst can be recovered and recycled through simple workup steps and reused up to five consecutive cycles without a marked loss in activity. The described catalytic systems proceed with a broad substrate scope, under microwave irradiation in aqueous medium and according to “click rules”.

scholarly journals Synthesis of spiro[benzo[4,5]imidazo[2,1-b][1,3]thiazole-2,3-thiolane]s via sulfa-Michael/aldol cascade reactions

2019 ◽  
Vol 43 (1-2) ◽  
pp. 63-66 ◽  
Author(s):  
Jiaying Lei ◽  
Xinliang Fu ◽  
Yulin Huang ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Resolution Mass

The sulfa-Michael/aldol cascade reaction of ( Z)-2-arylmethylidene-benzo[4,5]imidazo[2,1- b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2-aryl-4-hydroxy-spiro[benzo[4,5]imidazo[2,1- b][1,3]thiazole-2,3-thiolan]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared and high-resolution mass spectrometry together with X-ray crystallographic analysis.

scholarly journals Brushing the surface: cascade reactions between immobilized nanoreactors

Nanoscale ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 1551-1562 ◽  
Author(s):  
Dalin Wu ◽  
Serena Rigo ◽  
Stefano Di Leone ◽  
Andrea Belluati ◽  
Edwin C. Constable ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Cascade Reactions ◽  
Cascade Reaction

A tandem cascade reaction between polymer brushes-supported nanoreactors has been demonstrated.

ChemInform Abstract: Three-Component, Four-Molecule, Ru-Catalyzed Cascade Reactions of Indoles and Alkyl Bromides with Sodium Nitrite.

ChemInform ◽  
2015 ◽  
Vol 46 (28) ◽  
pp. no-no
Author(s):  
Hongen Qu ◽  
Jiuling Li ◽  
Huiliang Li ◽  
Hengshan Wang ◽  
Liangxian Liu
Keyword(s):  
Sodium Nitrite ◽  
Cascade Reactions ◽  
Alkyl Bromides

Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1552-1571 ◽  
Author(s):  
Jianxian Gong ◽  
Zhen Yang ◽  
Yueqing Gu ◽  
Ceheng Tan
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Left Wing ◽  
Asymmetric Total Synthesis ◽  
Diversity Oriented Synthesis ◽  
Active Natural

This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies.1 Introduction2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids2.2 Synthesis of Left-Wing Fragment of Azadirachtin I2.3 Collective Synthesis of Cladiellins3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins3.2 Total Synthesis of Orientalol F3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C4 Summary and Outlook

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