Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84025-84034 ◽  
Author(s):  
Sisini Sasidharan ◽  
Dhirendra Bahadur ◽  
Rohit Srivastava
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
High Stability ◽  
Ct Imaging ◽  
Gold Nanostars ◽  
Ct Contrast

Albumin stabilization of gold nanostars, which demonstrate high stability, biocompatibility, superior CT contrast, SERS and photothermal cytotoxicity towards cancer cells.

Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

2016 ◽  
Vol 4 (23) ◽  
pp. 4216-4226 ◽  
Author(s):  
Du Li ◽  
Yongxing Zhang ◽  
Shihui Wen ◽  
Yang Song ◽  
Yueqin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Gold Nanostars

A theranostic nanoplatform for in vivo CT imaging and enhanced PTT of tumors is reported.

Gold nanostars functionalized with amine-terminated PEG for X-ray/CT imaging and photothermal therapy

2015 ◽  
Vol 3 (21) ◽  
pp. 4330-4337 ◽  
Author(s):  
Ying Tian ◽  
Song Luo ◽  
Huaijiang Yan ◽  
Zhaogang Teng ◽  
Yuanwei Pan ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Ct Guided ◽  
X Ray ◽  
Gold Nanostars

We present the great potential of gold nanostars decorated with amine-terminated PEG in the application of X-ray/CT-guided photothermal therapy.

Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

2015 ◽  
Vol 44 (6) ◽  
pp. 2771-2779 ◽  
Author(s):  
Yuxin Zhang ◽  
Bo Li ◽  
Yunjiu Cao ◽  
Jinbao Qin ◽  
Zhiyou Peng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Ct Imaging ◽  
Dual Model ◽  
Photothermal Treatment ◽  
Nir Absorption

The hydrophilic Na0.3WO3 nanorods showed intense NIR absorption and large HU value, and thus can be used as a promising multifunctional agent for CT imaging and photothermal treatment of cancer.

scholarly journals Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

2014 ◽  
Vol 2 (30) ◽  
pp. 4862-4867 ◽  
Author(s):  
Hunho Jo ◽  
Hyungjun Youn ◽  
Seonghwan Lee ◽  
Changill Ban
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Prostate Cancer Cells ◽  
Gold Nanostars ◽  
Prostate Cancers ◽  
Disease Specific

A novel general platform for disease-specific photothermal therapy. This is the first demonstration of gold nanostars with tremendous efficiency and impressive selectivity for the targeted cancer, particularly the simultaneous targeting of PSMA(+) and PSMA(−) prostate cancers.

scholarly journals Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Lili Ye ◽  
Yaoming Chen ◽  
Jizong Mao ◽  
Xiaotian Lei ◽  
Qian Yang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Transfection Efficiency ◽  
Single Mode ◽  
Ct Imaging ◽  
Colon Cancer Cells ◽  
Proliferation And Apoptosis

Abstract Background The exploitation of novel nanomaterials combining diagnostic and therapeutic functionalities within one single nanoplatform is challenging for tumor theranostics. Methods We synthesized dendrimer-modified gold nanorods for combinational gene therapy and photothermal therapy (PTT) of colon cancer. Poly(amidoamine) dendrimers (PAMAM, G3) grafted gold nanorods were modified with GX1 peptide (a cyclic 7-mer peptide, CGNSNPKSC). The obtained Au NR@PAMAM-GX1 are proposed as a gene delivery vector to gene (FAM172A, regulates the proliferation and apoptosis of colon cancer cells) for the combination of photothermal therapy (PTT) and gene therapy of Colon cancer cells (HCT-8 cells). In addition, the CT imaging function of Au NR can provide imaging evidence for the diagnosis of colon cancer. Results The results display that Au NR@PAMAM-GX1 can specifically deliver FAM172A to cancer cells with excellent transfection efficiency. The HCT-8 cells treated with the Au NR@PAMAM-GX1/FAM172A under laser irradiation have a viability of 20.45%, which is much lower than the survival rate of other single-mode PTT treatment or single-mode gene therapy. Furthermore, animal experiment results confirm that Au NR@PAMAM-GX1/FAM172A complexes can achieve tumor thermal imaging, targeted CT imaging, PTT and gene therapy after tail vein injection. Conclusion Our findings demonstrate that the synthesized Au NR@PAMAM-GX1 offer a facile platform to exert antitumor and improve the diagnostic level of tumor.

Single-chain antibody-decorated Au nanocages@liposomal layer nanoprobes for targeted SERS imaging and remote-controlled photothermal therapy of melanoma cancer cells

2021 ◽  
Vol 124 ◽  
pp. 112086
Author(s):  
Ghazal Farahavar ◽  
Samira Sadat Abolmaali ◽  
Foroogh Nejatollahi ◽  
Amin Safaie ◽  
Sanaz Javanmardi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Melanoma Cancer ◽  
Sers Imaging
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