Dendrimer-Stabilized Gold Nanostars as a Multifunctional Theranostic Nanoplatform for CT Imaging, Photothermal Therapy, and Gene Silencing of Tumors

2016 ◽  
Vol 5 (24) ◽  
pp. 3203-3213 ◽  
Author(s):  
Ping Wei ◽  
Jingwen Chen ◽  
Yong Hu ◽  
Xin Li ◽  
Han Wang ◽  
...  
2016 ◽  
Vol 4 (23) ◽  
pp. 4216-4226 ◽  
Author(s):  
Du Li ◽  
Yongxing Zhang ◽  
Shihui Wen ◽  
Yang Song ◽  
Yueqin Tang ◽  
...  

A theranostic nanoplatform for in vivo CT imaging and enhanced PTT of tumors is reported.


2015 ◽  
Vol 3 (21) ◽  
pp. 4330-4337 ◽  
Author(s):  
Ying Tian ◽  
Song Luo ◽  
Huaijiang Yan ◽  
Zhaogang Teng ◽  
Yuanwei Pan ◽  
...  

We present the great potential of gold nanostars decorated with amine-terminated PEG in the application of X-ray/CT-guided photothermal therapy.


RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84025-84034 ◽  
Author(s):  
Sisini Sasidharan ◽  
Dhirendra Bahadur ◽  
Rohit Srivastava

Albumin stabilization of gold nanostars, which demonstrate high stability, biocompatibility, superior CT contrast, SERS and photothermal cytotoxicity towards cancer cells.


2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  

2021 ◽  
Author(s):  
Moataz Dowaidar

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.


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