scholarly journals Primaquine-based ionic liquids as a novel class of antimalarial hits

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56134-56138 ◽  
Author(s):  
Ricardo Ferraz ◽  
Joana Noronha ◽  
Fernanda Murtinheira ◽  
Fátima Nogueira ◽  
Marta Machado ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Low Cost ◽  
Antimalarial Drugs ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical antimalarial drugs.

scholarly journals Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1186
Author(s):  
Carmen S. Favaro-Trindade ◽  
Fernando E. de Matos Junior ◽  
Paula K. Okuro ◽  
João Dias-Ferreira ◽  
Amanda Cano ◽  
...  
Keyword(s):  
Oral Administration ◽  
Raw Materials ◽  
Low Cost ◽  
Pharmaceutical Formulations ◽  
Spray Cooling ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Taste And Odor ◽  
Cooling Technology ◽  
Simple Technology

Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.

Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

MedChemComm ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 559 ◽  
Author(s):  
O. Andreea Cojocaru ◽  
Katharina Bica ◽  
Gabriela Gurau ◽  
Asako Narita ◽  
Parker D. McCrary ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Liquid Form ◽  
Pharmaceutical Ingredients

scholarly journals Ionic Liquids as Active Pharmaceutical Ingredients

ChemMedChem ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. 975-985 ◽  
Author(s):  
Ricardo Ferraz ◽  
Luís C. Branco ◽  
Cristina Prudêncio ◽  
João Paulo Noronha ◽  
Željko Petrovski
Keyword(s):  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

The third evolution of ionic liquids: active pharmaceutical ingredients

2007 ◽  
Vol 31 (8) ◽  
pp. 1429 ◽  
Author(s):  
Whitney L. Hough ◽  
Marcin Smiglak ◽  
Héctor Rodríguez ◽  
Richard P. Swatloski ◽  
Scott K. Spear ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
The Third

scholarly journals The A Priori Design and Selection of Ionic Liquids as Solvents for Active Pharmaceutical Ingredients

2017 ◽  
Vol 23 (23) ◽  
pp. 5498-5508 ◽  
Author(s):  
Andreas J. Kunov‐Kruse ◽  
Cameron C. Weber ◽  
Robin D. Rogers ◽  
Allan S. Myerson
Keyword(s):  
Ionic Liquids ◽  
A Priori ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Selection Of

Thermodynamic Properties of Flufenamic Ionic Liquids

2014 ◽  
Vol 625 ◽  
pp. 586-591
Author(s):  
Fatimah Julia Romeli ◽  
Cecilia Devi Wilfred ◽  
Anis Shuib
Keyword(s):  
Thermal Stability ◽  
Ionic Liquids ◽  
Thermodynamic Properties ◽  
Molecular Volume ◽  
Standard Entropy ◽  
Active Pharmaceutical Ingredients ◽  
Density Data ◽  
Pharmaceutical Ingredients ◽  
Increasing Temperature ◽  
Experimental Density

Active pharmaceutical ingredients-ionic liquids (APIs-ILs) in which, when compared to active pharmaceutical ingredients hydrochloride (APIs-HCl), exhibits better solubility, increased thermal stability and significant enhancement in the efficiency of APIs. Three novel flufenamic-ILs were synthesized and their density and viscosities were determined and reported as a function of temperature. From the experimental density data the crystal energy, molecular volume and standard entropy was estimated. The result showed that the density and viscosities decrease with increasing temperature in these four ionic liquids.

scholarly journals Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 200
Author(s):  
Fátima A. R. Mota ◽  
Sarah A. P. Pereira ◽  
André R. T. S. Araujo ◽  
M. Lúcia M. F. S. Saraiva
Keyword(s):  
Enzyme Activity ◽  
Ionic Liquids ◽  
Sodium Salicylate ◽  
Raw Material ◽  
Human Neutrophil Elastase ◽  
Active Pharmaceutical Ingredients ◽  
Diagnostic Biomarker ◽  
Significant Information ◽  
Pharmaceutical Ingredients

Human neutrophil elastase (HNE) is used as diagnostic biomarker for inflammation/infection. In this work, 10 ionic liquids (ILs) and 11 ionic liquids active pharmaceutical ingredients (ILs-APIs) were tested to evaluate the inhibition effect on the activity of porcine pancreatic elastase enzyme, frequently employed as a model for HNE. The insertion of ionic liquids in some drugs is useful, as the insertion of ILs with inhibitory capacity will also slow down all processes in which this enzyme is involved. Therefore, a spectrophotometric method was performed to the determination of EC50 values of the compounds tested. EC50 values of 124 ± 4 mM to 289 ± 11 mM were obtained, with the most toxic IL for elastase being tetrabutylammonium acetate and the least toxic 1-butyl-3-methylimidazolium acetate. Moreover, sodium salicylate (raw material) presented the lower and benzethonium bistriflimide the higher EC50 when compared with all the IL-APIs tested. This work provides significant information about the effect of the studied IL and IL-APIs in elastase enzyme activity.

Multicomponent Crystals of an Artemisinin Derivative and Cinchona Alkaloids for Use as Antimalarial Drugs

CrystEngComm ◽  
2021 ◽  
Author(s):  
Qi Jiang ◽  
David A. Hirsh ◽  
Yifan Tu ◽  
Laibin Luo
Keyword(s):  
Physicochemical Properties ◽  
Antimalarial Drugs ◽  
Cinchona Alkaloids ◽  
Active Pharmaceutical Ingredients ◽  
Artemisinin Derivative ◽  
Pharmaceutical Ingredients

Pharmaceutical multicomponent crystals (MCCs) including salts and co-crystals of active pharmaceutical ingredients (APIs), are an active focus of research to improve various physicochemical properties of drugs. In this work, we...

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