An alternative technique for patterning cells on poly(ethylene glycol) diacrylate hydrogels

RSC Advances ◽  
2016 ◽  
Vol 6 (47) ◽  
pp. 40878-40885 ◽  
Author(s):  
Mathew Peter ◽  
Prakriti Tayalia
Keyword(s):  
Ethylene Glycol ◽  
Addition Reaction ◽  
Alternative Technique ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Cell Adhesive ◽  
A Cell ◽  
Michael Type Addition ◽  
Poly Ethylene

In this work, a poly(ethylene glycol) diacrylate (PEGDA) hydrogel is patterned with a cell adhesive ligand, that was functionalized with an acrylate group using Michael type addition reaction, thus, circumventing the need for proprietary reagents.

The Preparation of pH- and Thermo-Sensitive Chitosan-Based Hydrogels by Michael-Type Addition Reaction

2011 ◽  
Vol 130-134 ◽  
pp. 2392-2395
Author(s):  
Hong Liang Wei ◽  
Cun Cai Ma ◽  
Hui Juan Chu ◽  
Jing Zhu
Keyword(s):  
Ethylene Glycol ◽  
Potential Application ◽  
Addition Reaction ◽  
Poly Ethylene Glycol ◽  
Amino Groups ◽  
Mild Conditions ◽  
Primary Amino ◽  
Michael Type Addition ◽  
Poly Ethylene ◽  
Maleimide Group

The hydrogels based on chitosan were prepared by Michael-type addition reaction between chitosan's primary amino groups and maleimide group terminating poly (ethylene glycol) (PEG) under mild conditions. The hydrogels were characterizatied by FTIR, TG, etc. The study on the swelling behavior indicated that the hydrogels possess pH-and thermo-sensitivity. The chitosan-based hydogels crosslinked by Michael-type addition reaction have a potential application on biomaterials due to its biodegradability, biocompatibility, less toxicity and hydrophilicity.

Extracellular Matrix-like Cell-Adhesive Hydrogels from RGD-Containing Poly(ethylene glycol) Diacrylate

2006 ◽  
Vol 39 (4) ◽  
pp. 1305-1307 ◽  
Author(s):  
Junmin Zhu ◽  
Jeffrey A. Beamish ◽  
Chad Tang ◽  
Kandice Kottke-Marchant ◽  
Roger E. Marchant
Keyword(s):  
Extracellular Matrix ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Cell Adhesive ◽  
Poly Ethylene

Preparation and characterization of hydrogels based on acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) via Michael-type addition reaction

2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Huai-Qing Yu ◽  
Rimin Cong
Keyword(s):  
Ethylene Glycol ◽  
Addition Reaction ◽  
Gelation Time ◽  
Precursor Solution ◽  
Poly Ethylene Glycol ◽  
Biomedical Material ◽  
Michael Type Addition ◽  
Degradation Behaviors ◽  
Poly Ethylene

AbstractAn acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) (4A-PEG-PLA) macromer was firstly prepared. A novel kind of hydrogels was synthesized via the Michael-type addition reaction between (2S,3S)-1,4-bis-sulfanylbutane-2,3-diol (dithiothreitol) and this macromer. Gelation time was determined visually as the time when the precursor solution did not flow on inverting the vials. Hydrogel structure was characterized by FTIR analysis, swelling and degradation tests. It was found that colorless and transparent hydrogels were quickly generated in situ. The gelation time, swelling and degradation behaviors of this kind of hydrogels could be adjusted by changing the concentration of the macromer solution in PBS buffer (pH 7.4). This novel hydrogel is expected to be used as a biomedical material.

scholarly journals Biologically Engineered Protein-graft-Poly(ethylene glycol) Hydrogels:  A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair

2002 ◽  
Vol 3 (4) ◽  
pp. 710-723 ◽  
Author(s):  
Sven Halstenberg ◽  
Alyssa Panitch ◽  
Simone Rizzi ◽  
Heike Hall ◽  
Jeffrey A. Hubbell
Keyword(s):  
Ethylene Glycol ◽  
Tissue Repair ◽  
Poly Ethylene Glycol ◽  
Cell Adhesive ◽  
A Cell ◽  
Poly Ethylene

scholarly journals Gel Polymer Electrolytes Based on Cross-Linked Poly(ethylene glycol) Diacrylate for Calcium-Ion Conduction

ACS Omega ◽  
2021 ◽  
Author(s):  
Saeid Biria ◽  
Shreyas Pathreeker ◽  
Francielli S. Genier ◽  
Fu-Hao Chen ◽  
Hansheng Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Electrolytes ◽  
Calcium Ion ◽  
Gel Polymer Electrolytes ◽  
Poly Ethylene Glycol ◽  
Ion Conduction ◽  
Glycol Diacrylate ◽  
Poly Ethylene

scholarly journals Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2047
Author(s):  
Naofumi Naga ◽  
Mitsusuke Sato ◽  
Kensuke Mori ◽  
Hassan Nageh ◽  
Tamaki Nakano
Keyword(s):  
Ethylene Glycol ◽  
Room Temperature ◽  
Addition Reaction ◽  
Monomer Concentration ◽  
Diglycidyl Ether ◽  
Porous Polymers ◽  
Addition Reactions ◽  
Poly Ethylene Glycol ◽  
Network Polymers ◽  
Poly Ethylene

Addition reactions of multi-functional amine, polyethylene imine (PEI) or diethylenetriamine (DETA), and poly(ethylene glycol) diglycidyl ether (PEGDE) or poly(ethylene glycol) diacrylate (PEGDA), have been investigated to obtain network polymers in H2O, dimethyl sulfoxide (DMSO), and ethanol (EtOH). Ring opening addition reaction of the multi-functional amine and PEGDE in H2O at room temperature or in DMSO at 90 °C using triphenylphosphine as a catalyst yielded gels. Aza-Michael addition reaction of the multi-functional amine and PEGDA in DMSO or EtOH at room temperature also yielded corresponding gels. Compression test of the gels obtained with PEI showed higher Young’s modulus than those with DETA. The reactions of the multi-functional amine and low molecular weight PEGDA in EtOH under the specific conditions yielded porous polymers induced by phase separation during the network formation. The morphology of the porous polymers could be controlled by the reaction conditions, especially monomer concentration and feed ratio of the multi-functional amine to PEGDA of the reaction system. The porous structure was formed by connected spheres or a co-continuous monolithic structure. The porous polymers were unbreakable by compression, and their Young’s modulus increased with the increase in the monomer concentration of the reaction systems. The porous polymers absorbed various solvents derived from high affinity between the polyethylene glycol units in the network structure and the solvents.

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