Tailor-made poly(l-lactide)/poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds prepared via high-pressure compression molding/salt leaching

RSC Advances ◽  
2016 ◽  
Vol 6 (53) ◽  
pp. 47418-47426 ◽  
Author(s):  
Jin Zhang ◽  
Shu-Gui Yang ◽  
Jian-Xun Ding ◽  
Zhong-Ming Li
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
Degradation Rate ◽  
Compression Molding ◽  
Composite Scaffolds ◽  
Salt Leaching ◽  
Hydroxyapatite Composite

The degradation rate, hydrophilicity, and mechanical properties of PLLA/PLGA/HA scaffolds can be tuned by adjusting the composition. Such tailor-made scaffolds are hopeful to address the specific requirements of the regenerated tissue.

3D printed hydroxyapatite composite scaffolds with enhanced mechanical properties

2019 ◽  
Vol 45 (8) ◽  
pp. 10991-10996 ◽  
Author(s):  
Shangsi Chen ◽  
Yufei Shi ◽  
Xin Zhang ◽  
Jun Ma
Keyword(s):  
Mechanical Properties ◽  
Composite Scaffolds ◽  
Hydroxyapatite Composite ◽  
3D Printed

scholarly journals Factorial Study of Compressive Mechanical Properties and PrimaryIn VitroOsteoblast Response of PHBV/PLLA Scaffolds

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Naznin Sultana ◽  
Tareef Hayat Khan
Keyword(s):  
Mechanical Properties ◽  
Polymer Matrix ◽  
Tissue Regeneration ◽  
Degradation Rate ◽  
Bone Tissue Regeneration ◽  
Osteoblastic Cells ◽  
Composite Scaffolds ◽  
Biomimetic Systems ◽  
Human Osteoblastic Cells

For bone tissue regeneration, composite scaffolds containing biodegradable polymers and nanosized osteoconductive bioceramics have been regarded as promising biomimetic systems. Polymer blends of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(L-lactic acid) (PLLA) can be used as the polymer matrix to control the degradation rate. In order to render the scaffolds osteoconductive, nano-sized hydroxyapatite (nHA) particles can be incorporated into the polymer matrix. In the first part of this study, a factorial design approach to investigate the influence of materials on the initial compressive mechanical properties of the scaffolds was studied. In the second part, the protein adsorption behavior and the attachment and morphology of osteoblast-like cells (Saos-2) of the scaffoldsin vitrowere also studied. It was observed that nHA incorporated PHBV/PLLA composite scaffolds adsorbed more bovine serum albumin (BSA) protein than PHBV or PHBV/PLLA scaffolds.In vitrostudies also revealed that the attachment of human osteoblastic cells (SaOS-2) was significantly higher in nHA incorporated PHBV/PLLA composite scaffolds. From the SEM micrographs of nHA incorporated PHBV/PLLA composite scaffolds seeded with SaOS-2 cells after a 7-day cell culture period, it was observed that the cells were well expanded and spread in all directions on the scaffolds.

Degradability Research of Nano-PLLA/Chitosan Composite Scaffolds

2013 ◽  
Vol 650 ◽  
pp. 245-248
Author(s):  
Li Yong Lv ◽  
Xue Jun Wang ◽  
Tao Lou ◽  
Chong Sui ◽  
Guo Jun Song
Keyword(s):  
Mechanical Properties ◽  
Phase Separation ◽  
Degradation Rate ◽  
Thermally Induced Phase Separation ◽  
Composite Scaffolds ◽  
Thermally Induced ◽  
Chitosan Scaffolds ◽  
Chitosan Composite

Nano-PLLA/chitosan scaffolds were prepared through thermally induced phase separation(TIPS). With incorporation of chitosan fibers, composites not only improved the mechanical properties of nano scaffolds, but also reduced the degradation rate of mechanical properties which deepen the applications of scaffolds better.

Polymer coated phosphate glass/hydroxyapatite composite scaffolds for bone tissue engineering applications

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60188-60198 ◽  
Author(s):  
R. Govindan ◽  
G. Suresh Kumar ◽  
E. K. Girija
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Phosphate Glass ◽  
Composite Scaffolds ◽  
Engineering Applications ◽  
Hydroxyapatite Composite

Biopolymer coated PG/HA composite scaffolds were prepared with enhanced mechanical properties for bone tissue engineering applications.

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