Skeleton selectivity in complexation of chelerythrine and chelerythrine-like natural plant alkaloids with the G-quadruplex formed at the promoter of c-MYC oncogene: in silico exploration

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36667-36680 ◽  
Author(s):  
Jyotsna Bhat ◽  
Subhrangsu Chatterjee
Keyword(s):  
In Silico ◽  
Promoter Region ◽  
Methoxy Group ◽  
Binding Pattern ◽  
Natural Plant ◽  
Myc Oncogene ◽  
The Core ◽  
G Quadruplex ◽  
Plant Alkaloids

Chelerythrine binds at the 5′ end and arrests the G-quadruplex formed in the promoter region ofc-MYConcogene thus restrict thec-MYCexpression. Position of methoxy group over the core skeleton of chelerythrine determines the binding pattern of ligand.

To probe the binding pathway of a selective compound (D089-0563) to c-MYC Pu24 G-quadruplex using free ligand binding simulations and Markov state model analysis

2020 ◽  
Vol 22 (39) ◽  
pp. 22567-22583
Author(s):  
Brian Chen ◽  
Griffin Fountain ◽  
Holli-Joi Sullivan ◽  
Nicholas Paradis ◽  
Chun Wu
Keyword(s):  
Ligand Binding ◽  
Promoter Region ◽  
Free Ligand ◽  
State Model ◽  
Binding Mechanism ◽  
Myc Oncogene ◽  
Markov State Model ◽  
Markov State ◽  
Anti Cancer ◽  
G Quadruplex

D089-0563 is a highly promising anti-cancer compound that selectively binds the transcription-silencing G-quadruplex element (Pu27) at the promoter region of the human c-MYC oncogene; however, its binding mechanism remains elusive.

scholarly journals Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

2016 ◽  
Vol 52 (92) ◽  
pp. 13511-13514 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Benjamin J. Pinchbeck ◽  
Bhovina Seewoodharry Buguth ◽  
Timothy G. Meadows ◽  
David J. Richardson ◽  
...  
Keyword(s):  
Promoter Region ◽  
Paracoccus Denitrificans ◽  
Nitrate Assimilation ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Specific Control

Ligand-specific control of nitrate assimilation inParacoccus denitrificansby stabilization of DNA G-quadruplex in the promoter region ofnas.

Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

Biopolymers ◽  
2014 ◽  
Vol 101 (10) ◽  
pp. 1038-1050 ◽  
Author(s):  
Sheh-Yi Sheu ◽  
Chao-Hsien Huang ◽  
Jia-Kai Zhou ◽  
Dah-Yen Yang
Keyword(s):  
Relative Stability ◽  
Promoter Region ◽  
G Quadruplex ◽  
Derivatives Of

An in Silico Investigation of Binding Modes and Pathway of APTO-253 on c-KIT G-Quadruplex DNA

2020 ◽  
Author(s):  
Saikat Pal ◽  
Sandip Paul
Keyword(s):  
Cancer Therapy ◽  
In Silico ◽  
Binding Modes ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
The Stability

The stability of c-KIT G-quadruplex DNA by ligands has been a significant concern in the growing field of cancer therapy. Thus, it is very important to understand the mechanism behind...

scholarly journals Volumetric Interplay between the Conformational States Adopted by DNA Strands from the Promoter Region of the c-MYC Oncogene

2021 ◽  
Vol 120 (3) ◽  
pp. 218a-219a
Author(s):  
Lutan Liu ◽  
Lily Scott ◽  
Takuma Kume ◽  
Tigran V. Chalikian
Keyword(s):  
Promoter Region ◽  
Conformational States ◽  
Myc Oncogene ◽  
Dna Strands

scholarly journals The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

1992 ◽  
Vol 12 (3) ◽  
pp. 1352-1356 ◽  
Author(s):  
D C Leitman ◽  
E R Mackow ◽  
T Williams ◽  
J D Baxter ◽  
B L West
Keyword(s):  
Transcription Factors ◽  
Tumor Necrosis Factor ◽  
Promoter Region ◽  
Tumor Necrosis ◽  
Core Promoter ◽  
Core Promoter Region ◽  
Necrosis Factor Alpha ◽  
The Core ◽  
Factor Alpha ◽  
Necrosis Factor

Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors. To investigate the mechanism whereby TPA activates the TNF promoter, a series of 5'-deletion mutants of the human TNF promoter linked to chloramphenicol acetyltransferase was transfected into U937 human promonocytic cells. TPA produced a 7- to 11-fold activation of all TNF promoters tested, even those promoters truncated to contain only the core promoter with no upstream enhancer elements. The proximal TNF promoter containing only 28 nucleotides upstream and 10 nucleotides downstream of the RNA start site confers TPA activation to a variety of unrelated upstream enhancer elements and transcription factors, including Sp1, CTF/NF1, cyclic AMP-response element, GAL-E1a, and GAL-VP16. The level of activation by TPA depends on the TATA box structure, since the TPA response is greater in promoters containing the sequence TATAAA than in those containing TATTAA or TATTTA. These findings suggest that the core promoter region is a target for gene regulation by second-messenger pathways.

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