Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

Biopolymers ◽  
2014 ◽  
Vol 101 (10) ◽  
pp. 1038-1050 ◽  
Author(s):  
Sheh-Yi Sheu ◽  
Chao-Hsien Huang ◽  
Jia-Kai Zhou ◽  
Dah-Yen Yang
Keyword(s):  
Relative Stability ◽  
Promoter Region ◽  
G Quadruplex ◽  
Derivatives Of

scholarly journals Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

2016 ◽  
Vol 52 (92) ◽  
pp. 13511-13514 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Benjamin J. Pinchbeck ◽  
Bhovina Seewoodharry Buguth ◽  
Timothy G. Meadows ◽  
David J. Richardson ◽  
...  
Keyword(s):  
Promoter Region ◽  
Paracoccus Denitrificans ◽  
Nitrate Assimilation ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Specific Control

Ligand-specific control of nitrate assimilation inParacoccus denitrificansby stabilization of DNA G-quadruplex in the promoter region ofnas.

scholarly journals Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103876 ◽  
Author(s):  
Silvia Da Ros ◽  
Eleonora Zorzan ◽  
Mery Giantin ◽  
Lara Zorro Shahidian ◽  
Manlio Palumbo ◽  
...  
Keyword(s):  
Human Disease ◽  
Promoter Region ◽  
G Quadruplex

Stability of the 1,4-bis(2′-haloethyl)-1,4-diazabicyclo[2.2.1]heptane dication

1981 ◽  
Vol 59 (2) ◽  
pp. 217-221 ◽  
Author(s):  
George R. Pettit ◽  
Donald P. Gieschen ◽  
William E. Pettit ◽  
Thomas E. Rawson
Keyword(s):  
Ion Exchange ◽  
Relative Stability ◽  
Heterocyclic System ◽  
Rapid Preparation ◽  
Anticancer Properties ◽  
Convenient Synthesis ◽  
Neutral Conditions ◽  
Derivatives Of

Certain derivatives of the 1,4-bis(2′-haloethyl)-1,4-diazabicyclo[2.2.1]heptane dication system ranging from dibromide 2b to ethanesulfonate 2g were found to be quite stable under essentially neutral conditions. A very convenient synthesis of 1,4-bis(2′-chloroethyl)-1,4-diazabicyclo [2.2.1]heptane dichloride (2d) was developed in order to compare the relative stability of this system with that of dibromide 2b. While dichloride 2d was found to be less stable than dibromide 2b, it did prove very useful for rapid preparation of other anion derivatives such as dinitrate 2e, dihydrogen dimaleate 2h, diperiodate 2i, tetrachloroplatinate 2j, and tetrachloroaurate 2k. At temperatures near 150 °C, or upon ignition (in the open) or gentle shock, diperiodate2i detonated violently. The ethanesulfonate 2g was obtained from diperchlorate 2a employing an ion-exchange procedure. Stabilization of dication 2 provides an unusual heterocyclic system with exceptional anticancer properties.

scholarly journals Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA

2016 ◽  
Vol 21 (2) ◽  
pp. 227-239 ◽  
Author(s):  
Navin C. Sabharwal ◽  
Oscar Mendoza ◽  
John M. Nicoludis ◽  
Thomas Ruan ◽  
Jean-Louis Mergny ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
Derivatives Of

scholarly journals Effect of Ionic Strength on Porphyrin Drugs Interaction with Quadruplex DNA Formed by the Promoter Region of C-myc and Bcl2 Oncogenes

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Narayana Nagesh ◽  
Varun K. Sharma ◽  
A. Ganesh Kumar ◽  
Edwin A. Lewis
Keyword(s):  
Ionic Strength ◽  
Fluorescence Spectroscopy ◽  
Drug Interactions ◽  
Promoter Region ◽  
Promoter Regions ◽  
Quadruplex Dna ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Drugs Interaction ◽  
Dna Complex

C-myc and Bcl2 are well characterized oncogenes that are capable of forming G-quadruplex structures. Promoter regions of C-myc and Bcl2 forming G-quadruplex structures are chemically synthesized and G-quadruplex structure is formed in presence of 100 mM potassium ion. Three different porphyrin drugs, namely TMPyP2, TMPyP3, and TMPyP4 are allowed to interact with quadruplex DNA complex and the site and nature of interaction are studied. Drug interactions with quadruplex DNA were carried out in different potassium ionic strengths using fluorescence spectroscopy. It is found that fluorescence hypochromicity decreases with an increase in ionic strength in the case of TMPyP4, TMPyP3, and TMPyP2. Fluorescence titration studies and Job plots indicate that four molecules of TMPyP4, two molecules of TMPyP3 and TMPyP2 are interacting with one molecule of quadruplex DNA.

scholarly journals Energetic and Geometric Characteristics of Substituents, Part 3: The Case of NO2 and NH2 Groups in Their Mono-Substituted Derivatives of Six-Membered Heterocycles

Symmetry ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 145
Author(s):  
Paweł A. Wieczorkiewicz ◽  
Halina Szatylowicz ◽  
Tadeusz M. Krygowski
Keyword(s):  
Active Region ◽  
Electronic Properties ◽  
Electron Density ◽  
Relative Stability ◽  
Theoretical Study ◽  
Functional Materials ◽  
Electronic Interactions ◽  
Geometric Descriptors ◽  
Energy Of Interaction ◽  
Derivatives Of

Substituted heterocyclic arenes play important roles in biochemistry, catalysis, and in the design of functional materials. Exemplary six-membered heteroaromatic molecules, that differ from benzene by inclusion of one heteroatom, are pyridine, phosphorine, arsabenzene, and borabenzene. This theoretical study concerns the influence of the heteroatom present in these molecules on the properties of substituents of two types: electron-donating (ED) NH2 group and electron-accepting (EA) NO2 group, attached at the 2-, 3-, or 4-position. The effect is evaluated by the energy of interaction (Erel) between the substituent and the substituted system and electronic properties of the substituents described by the charge of the substituent active region (cSAR) index. In addition, several geometric descriptors of the substituent and heteroaromatic ring, as well as changes in the aromaticity, are considered. The latter are assessed using the Electron Density of Delocalized Bonds (EDDBs) property of delocalized π electrons. The obtained results show that the electronegativity (EN) of the heteroatom has a profound effect on the EA/ED properties of the substituents. This effect is also reflected in the geometry of studied molecules. The Erel parameter indicates that the relative stability of the molecules is highly related to the electronic interactions between the substituent and the heteroarene. This especially applies to the enhancement or weakening of π-resonance due to the EN of the heteroatom. Additionally, in the 2-heteroarene derivatives, specific through-space ortho interactions contribute to the heteroatom effects.

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