pH-sensitive nanomedicine based on PEGylated nanodiamond for enhanced tumor therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36407-36417 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
Yingqi Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Therapy ◽  
Ph Sensitive ◽  
Sustained Drug Release

pH-sensitive nanomedicine based on PEGylated nanodiamond with excellent dispersity, a slow and sustained drug release capability for enhanced tumor therapy.

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

2020 ◽  
pp. 088532822095259
Author(s):  
Ke Ma ◽  
Yongbin Cheng ◽  
Xinran Wei ◽  
Daijun Chen ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Drug Release ◽  
Fluorescence Imaging ◽  
Colloidal Stability ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Chitosan Nanoparticles ◽  
Fluorescence Emission ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
One Pot

In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

scholarly journals Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9497-9504 ◽  
Author(s):  
Devleena Samanta ◽  
Jana L. Meiser ◽  
Richard N. Zare
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
Sustained Drug Release ◽  
Drug Molecules ◽  
Polypyrrole Nanoparticles

Charged drug molecules from nanoparticles are released by changing the pH of the surroundings and fine-tuned by adding appropriate amphiphiles.

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

Simulation study of the pH sensitive directed self-assembly of rheins for sustained drug release hydrogel

2020 ◽  
Vol 195 ◽  
pp. 111260 ◽  
Author(s):  
Yun Hao Feng ◽  
Xiao Peng Zhang ◽  
Yu Ying Hao ◽  
Gui Yao Ren ◽  
Xin Dong Guo
Keyword(s):  
Drug Release ◽  
Simulation Study ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Sustained Drug Release

Cyclodextrin-phenylboronic acid cross-linked hydrogel with drug hosting, self-healing and pH-sensitive for sustained drug release

2021 ◽  
Author(s):  
Daijun Chen ◽  
Guanglei Ren ◽  
Xiaoli Zhao ◽  
Jinni Luo ◽  
Huanxia Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Phenylboronic Acid ◽  
Ph Sensitive ◽  
Self Healing ◽  
Practical Application ◽  
Sustained Drug Release ◽  
Simple Method ◽  
Healing Property

The rapid drug release and poor self-healing property of drug-loaded hydrogel largely limit its practical application. Herein, we presented a simple method to prepare hydrogel with self-healing, drug hosting and...

Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers

2017 ◽  
Vol 32 (6) ◽  
pp. 826-838 ◽  
Author(s):  
Li Cao ◽  
Yi Xiao ◽  
Wei Lu ◽  
Shiyuan Liu ◽  
Lin Gan ◽  
...  
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Ph Value ◽  
Ph Sensitive ◽  
Critical Aggregation Concentration ◽  
Hydrodynamic Diameter ◽  
Average Particle ◽  
Sustained Drug Release ◽  
Doxorubicin Release

In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide). In vitro studies revealed that mPEG-g-P(ae-Asp)-Hap copolymer was stable in neutral solutions but tend to be hydrolyzed under acidic condition, which was attributed to the acid-sensitive properties of hexahydrophthalic amides (β-carboxylic amides). MPEG-g-P(ae-Asp)-Hap copolymer with critical aggregation concentration of 0.166 mg·mL−1 could self-assemble into stable blank nanomicelles with an average particle hydrodynamic diameter of 98.1 nm, but the hydrodynamic diameter of doxorubicin-loaded nanomicelles (mPEG-g-P(ae-Asp)-Hap·Dox) was smaller and approximately 77.5 nm. MPEG-g-P(ae-Asp)-Hap·Dox nanomicelles showed sustained drug release profiles over 34 h, and the cumulative drug release showed a tendency to increase from 25% to 62% with the pH value decreasing from 7.4 to 5.0 due to the acid-triggered disassembly of nanomicelles. The cytotoxicity of mPEG-g-P(ae-Asp)-Hap·Dox nanomicelles against A549 treated with 40 mM NH4Cl (lysosomotropic weak bases) was decreased significantly than that without NH4Cl treatment, further confirmed the drug release from the nanomicelles was triggered by the low pH value of lysosome (pH 5.0). Compared with doxorubicin HCl, mPEG-g-P(ae-Asp)-Hap·Dox nanomicelle drug showed enhanced cellular uptake ability during 2 or 4 h of incubation due to the endocytosis mechanism of nanomicelle drug. In summary, the cleavage of pH-sensitive β-carboxylic amides bonds on the hydrophobic branch of mPEG-g-P(ae-Asp)-Hap copolymer triggered the disassembly of the nanomicelles and release of doxorubicin in the acidic lysosomal compartments of cancer cells. These nanomicelles exhibited excellent potential for drug delivery due to their smart properties-PEGylation, suitable size, and acid-triggered drug release.

Cytochrome C capped mesoporous silica nanocarriers for pH-sensitive and sustained drug release

2014 ◽  
Vol 2 (27) ◽  
pp. 4356-4362 ◽  
Author(s):  
Yuxia Tang ◽  
Zhaogang Teng ◽  
Ying Liu ◽  
Ying Tian ◽  
Jing Sun ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Ph Sensitive ◽  
Sustained Drug Release ◽  
Drug Nanocarriers ◽  
Pore Blocker

Drug nanocarriers with pH-sensitive and sustained drug release properties were constructed by using cytochrome C as a pore blocker to achieve high therapeutic efficacy for cancer.

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