scholarly journals Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9497-9504 ◽  
Author(s):  
Devleena Samanta ◽  
Jana L. Meiser ◽  
Richard N. Zare
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
Sustained Drug Release ◽  
Drug Molecules ◽  
Polypyrrole Nanoparticles

Charged drug molecules from nanoparticles are released by changing the pH of the surroundings and fine-tuned by adding appropriate amphiphiles.

scholarly journals Glibenclamide-Loaded Polyvinylpyrrolidone (PVP) Nanoparticles and Glibenclamide-Loaded Soluplus® Nanomicelles Intended for Parenteral Administration: Effect of Solvents Mixtures on the Electrosprayed Nanoparticles and In vitro Characterization

2021 ◽  
pp. 241-260
Author(s):  
Maryam Al-Ghezi ◽  
Raghad F. Almilly ◽  
Wedad K. Ali
Keyword(s):  
Drug Release ◽  
Physicochemical Characteristics ◽  
Colloidal Dispersions ◽  
Parenteral Administration ◽  
Solvent Mixtures ◽  
X Ray Diffraction ◽  
Sustained Drug Release ◽  
Drug Molecules ◽  
In Vitro Characterization

Background and Objective: Glibenclamide (GB) is showing promising results in central nervous system (CNS) injuries treatment where intravenous administration of GB could overcome the oral limitations and assure maximum bioavailability. Dry powder of GB nanoparticles reconstituted for parenteral administration was prepared through electrospraying. Methods: The drug was incorporated with two polymers, polyvinylpyrrolidone (PVP) and Soluplus® (SP), at ratios 1:4 and 1:2 (GB/polymer). Different solvent mixtures were used to formulate the particles. Physicochemical characteristics were investigated. Results: The size of the GB-PVP nanoparticle ranged between (409-775) nm with a spherical, disk, fractured and, agglomerated morphology, while those of the GB-SP nanomicelles were of (447-785) nm with mostly irregular morphology, in consequence to the used solvents mixtures. The high encapsulation efficiency ≥ 98% reflects the well dispersed drug molecules within the polymer matrix, further confirmed by X-ray diffraction and infrared spectroscopy. GB-SP colloidal dispersions showed neutral zeta potentials with a cloud point of 36 ˚C, indicating prolonged circulation time and stability after parenteral administration. GB/SP nanomicelles at ratio 1:4 showed a sustained drug release reaching ≥ 94% in 36 hours. Conclusion: The GB-SP nanomicelles with extended drug release and regarding physicochemical properties represent a remarkable drug delivery system for parenteral administration.

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

Simulation study of the pH sensitive directed self-assembly of rheins for sustained drug release hydrogel

2020 ◽  
Vol 195 ◽  
pp. 111260 ◽  
Author(s):  
Yun Hao Feng ◽  
Xiao Peng Zhang ◽  
Yu Ying Hao ◽  
Gui Yao Ren ◽  
Xin Dong Guo
Keyword(s):  
Drug Release ◽  
Simulation Study ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Sustained Drug Release

Cyclodextrin-phenylboronic acid cross-linked hydrogel with drug hosting, self-healing and pH-sensitive for sustained drug release

2021 ◽  
Author(s):  
Daijun Chen ◽  
Guanglei Ren ◽  
Xiaoli Zhao ◽  
Jinni Luo ◽  
Huanxia Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Phenylboronic Acid ◽  
Ph Sensitive ◽  
Self Healing ◽  
Practical Application ◽  
Sustained Drug Release ◽  
Simple Method ◽  
Healing Property

The rapid drug release and poor self-healing property of drug-loaded hydrogel largely limit its practical application. Herein, we presented a simple method to prepare hydrogel with self-healing, drug hosting and...

Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers

2017 ◽  
Vol 32 (6) ◽  
pp. 826-838 ◽  
Author(s):  
Li Cao ◽  
Yi Xiao ◽  
Wei Lu ◽  
Shiyuan Liu ◽  
Lin Gan ◽  
...  
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Ph Value ◽  
Ph Sensitive ◽  
Critical Aggregation Concentration ◽  
Hydrodynamic Diameter ◽  
Average Particle ◽  
Sustained Drug Release ◽  
Doxorubicin Release

In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide). In vitro studies revealed that mPEG-g-P(ae-Asp)-Hap copolymer was stable in neutral solutions but tend to be hydrolyzed under acidic condition, which was attributed to the acid-sensitive properties of hexahydrophthalic amides (β-carboxylic amides). MPEG-g-P(ae-Asp)-Hap copolymer with critical aggregation concentration of 0.166 mg·mL−1 could self-assemble into stable blank nanomicelles with an average particle hydrodynamic diameter of 98.1 nm, but the hydrodynamic diameter of doxorubicin-loaded nanomicelles (mPEG-g-P(ae-Asp)-Hap·Dox) was smaller and approximately 77.5 nm. MPEG-g-P(ae-Asp)-Hap·Dox nanomicelles showed sustained drug release profiles over 34 h, and the cumulative drug release showed a tendency to increase from 25% to 62% with the pH value decreasing from 7.4 to 5.0 due to the acid-triggered disassembly of nanomicelles. The cytotoxicity of mPEG-g-P(ae-Asp)-Hap·Dox nanomicelles against A549 treated with 40 mM NH4Cl (lysosomotropic weak bases) was decreased significantly than that without NH4Cl treatment, further confirmed the drug release from the nanomicelles was triggered by the low pH value of lysosome (pH 5.0). Compared with doxorubicin HCl, mPEG-g-P(ae-Asp)-Hap·Dox nanomicelle drug showed enhanced cellular uptake ability during 2 or 4 h of incubation due to the endocytosis mechanism of nanomicelle drug. In summary, the cleavage of pH-sensitive β-carboxylic amides bonds on the hydrophobic branch of mPEG-g-P(ae-Asp)-Hap copolymer triggered the disassembly of the nanomicelles and release of doxorubicin in the acidic lysosomal compartments of cancer cells. These nanomicelles exhibited excellent potential for drug delivery due to their smart properties-PEGylation, suitable size, and acid-triggered drug release.

Cytochrome C capped mesoporous silica nanocarriers for pH-sensitive and sustained drug release

2014 ◽  
Vol 2 (27) ◽  
pp. 4356-4362 ◽  
Author(s):  
Yuxia Tang ◽  
Zhaogang Teng ◽  
Ying Liu ◽  
Ying Tian ◽  
Jing Sun ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Ph Sensitive ◽  
Sustained Drug Release ◽  
Drug Nanocarriers ◽  
Pore Blocker

Drug nanocarriers with pH-sensitive and sustained drug release properties were constructed by using cytochrome C as a pore blocker to achieve high therapeutic efficacy for cancer.

pH-sensitive nanomedicine based on PEGylated nanodiamond for enhanced tumor therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36407-36417 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
Yingqi Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Therapy ◽  
Ph Sensitive ◽  
Sustained Drug Release

pH-sensitive nanomedicine based on PEGylated nanodiamond with excellent dispersity, a slow and sustained drug release capability for enhanced tumor therapy.

Synthesis, Characterization and in-vitro drug release studies of a macromolecular prodrug of Didanosine.

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Neeraj Agrawal ◽  
M.J. Chandrasekar ◽  
U.V. Sara ◽  
Rohini A.
Keyword(s):  
Drug Release ◽  
Drug Level ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Alkaline Environment ◽  
Stomach Acid ◽  
Release Studies ◽  
Macromolecular Prodrug

A macromolecular prodrug of didanosine (ddI) for oral administration was synthesized and evaluated for in-vitro drug release profile. Didanosine was first coupled to 2-hydroxy ethyl methacrylate (HEMA) through a succinic spacer to form HEMA-Suc-ddI monomeric conjugate which was subsequently polymerized to yield Poly(HEMA-Suc-ddI) conjugate. The structures of the synthesized compounds were characterized by FT-IR, Mass and 1H-NMR spectroscopy. The prodrug was subjected for in-vitro drug release studies in buffers of pH 1.2 and 7.4 mimicking the upper and lower GIT. The results showed that the drug release from the polymeric backbone takes place in a sustained manner over a period of 24 h and the amount of drug released was comparatively higher at pH 7.4 indicating that the drug release takes place predominantly at the alkaline environment of the lower GIT rather than at the acidic environment of the upper GIT. This pH dependent sustained drug release behavior of the prodrug may be capable of reducing the dose limiting toxicities by maintaining the plasma drug level within the therapeutic range and increasing t1/2 of ddI. Moreover, the bioavailability of the drug should be improved as the prodrug releases ddI predominantly in the alkaline environment which will reduce the degradation of ddI in the stomach acid.

Formulation and Evaluation of Chitosan-Polyaniline Nanocomposites for Controlled Release of Anticancer Drug Doxorubicin

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Dillip Kumar Behera ◽  
Kampal Mishra ◽  
Padmolochan Nayak
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Nanocomposite Films ◽  
Casting Method ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Clay Particles ◽  
Solution Casting Method ◽  
Nanoclay Content

In this present work, chitosan (CS) crosslink with polyaniline (PANI) with montmorilonite (MMT) called as (CSPANI/MMT) and CS crosslink with PANI without MMT called as (CS-PANI) were prepared by employing the solution casting method. Further the formation of nanocomposites CS-PANI/MMT and CS-PANI were investigated using XRD, FTIR, SEM and tensile strength. Water uptake and swelling ratio of the CS-PANI and CS-PANI/MMT were found to decrease with increase in concentration of clay. Mechanical properties of the CS-PANI and CS-PANI/MMT were assessed in terms of tensile strength and extensibility using texture analyzer. Increase in tensile strength and reduction in extensibility was reported with increase in the nanoclay content. In vitro drug release study on CS-PANI and CS-PANI/MMT indicated pronounced sustained release of doxorubicin by the incorporation of clay particles in the CS polymer matrix. Overall CSPANI/MMT nanocomposite films exhibited improved mechanical and sustained drug release properties than CS-PANI.

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