Two new mixed copper(ii)–dipeptide complexes of N,N-donor heterocycle ligands: studies on their non-covalent DNA binding, chemical nuclease, antioxidant and anticancer activities

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35952-35965 ◽  
Author(s):  
Qian Gan ◽  
Chun-Lian Zhang ◽  
Bing-Feng Wang ◽  
Ya-Hong Xiong ◽  
Yin-Lian Fu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Dna Interactions ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Chemical Nuclease

Two novel mononuclear mixed ligand copper(ii)-dipeptide complexes have been synthesized. The DNA interactions of the complexes were investigated. In addition, the antioxidant and antitumor activities of the complexes were evaluated.

scholarly journals Synthesis, DFT Calculations, Antiproliferative, Bactericidal Activity and Molecular Docking of Novel Mixed-Ligand Salen/8-Hydroxyquinoline Metal Complexes

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4725
Author(s):  
Badriah Saad Al-Farhan ◽  
Maram T. Basha ◽  
Laila H. Abdel Rahman ◽  
Ahmed M. M. El-Saghier ◽  
Doaa Abou El-Ezz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Wide Spectrum ◽  
Mixed Ligand ◽  
Molecular Formula ◽  
Hep G2 ◽  
Anticancer Activities ◽  
Azomethine Group ◽  
Ic50 Values

Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive agents, their metal complexes are still under development. Here, we report the synthesis of novel mixed-ligand metal complexes (MSQ) comprising salen (S), derived from (2,2′-{1,2-ethanediylbis[nitrilo(E) methylylidene]}diphenol, and 8-hydroxyquinoline (Q) with Co(II), Ni(II), Cd(II), Al(III), and La(III). The structures and properties of these MSQ metal complexes were investigated using molar conductivity, melting point, FTIR, 1H NMR, 13C NMR, UV–VIS, mass spectra, and thermal analysis. Quantum calculation, analytical, and experimental measurements seem to suggest the proposed structure of the compounds and its uncommon monobasic tridentate binding mode of salen via phenolic oxygen, azomethine group, and the NH group. The general molecular formula of MSQ metal complexes is [M(S)(Q)(H2O)] for M (II) = Co, Ni, and Cd or [M(S)(Q)(Cl)] and [M(S)(Q)(H2O)]Cl for M(III) = La and Al, respectively. Importantly, all prepared metal complexes were evaluated for their antimicrobial and anticancer activities. The metal complexes exhibited high cytotoxic potency against human breast cancer (MDA-MB231) and liver cancer (Hep-G2) cell lines. Among all MSQ metal complexes, CoSQ and LaSQ produced IC50 values (1.49 and 1.95 µM, respectively) that were comparable to that of cisplatin (1.55 µM) against Hep-G2 cells, whereas CdSQ and LaSQ had best potency against MDA-MB231 with IC50 values of 1.95 and 1.43 µM, respectively. Furthermore, the metal complexes exhibited significant antimicrobial activities against a wide spectrum of both Gram-positive and -negative bacterial and fungal strains. The antibacterial and antifungal efficacies for the MSQ metal complexes, the free S and Q ligands, and the standard drugs gentamycin and ketoconazole decreased in the order AlSQ > LaSQ > CdSQ > gentamycin > NiSQ > CoSQ > Q > S for antibacterial activity, and for antifungal activity followed the trend of LaSQ > AlSQ > CdSQ > ketoconazole > NiSQ > CoSQ > Q > S. Molecular docking studies were performed to investigate the binding of the synthesized compounds with breast cancer oxidoreductase (PDB ID: 3HB5). According to the data obtained, the most probable coordination geometry is octahedral for all the metal complexes. The molecular and electronic structures of the metal complexes were optimized theoretically, and their quantum chemical parameters were calculated. PXRD results for the Cd(II) and La(III) metal complexes indicated that they were crystalline in nature.

Mixed ligand Ni(II) complexes: DNA binding, oxidative and photo-cleavage studies

2008 ◽  
Vol 7 (2) ◽  
pp. 97-107 ◽  
Author(s):  
M. C. Prabhakara ◽  
H. S. Bhojya Naik
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Photo Cleavage

Photophysical properties and DNA binding studies of novel Eu 3+ mixed ligand complex

2016 ◽  
Vol 177 ◽  
pp. 416-424 ◽  
Author(s):  
Sneha R. Wankar ◽  
Umar Jan Pandit ◽  
Imran Khan ◽  
S.N. Limaye
Keyword(s):  
Dna Binding ◽  
Photophysical Properties ◽  
Mixed Ligand Complex ◽  
Mixed Ligand ◽  
Binding Studies ◽  
Ligand Complex ◽  
Dna Binding Studies

Synthesis, structures, DNA-binding and anticancer activities of some copper(I)-phosphine complexes

Polyhedron ◽  
2019 ◽  
Vol 158 ◽  
pp. 164-172 ◽  
Author(s):  
Khlood H. Mashat ◽  
Bandar A. Babgi ◽  
Mostafa A. Hussien ◽  
Muhammad Nadeem Arshad ◽  
Magda H. Abdellattif
Keyword(s):  
Dna Binding ◽  
Anticancer Activities ◽  
Phosphine Complexes

A supramolecular adduct of tegafur and syringic acid: the first tegafur-nutraceutical cocrystal with perfected in vitro and in vivo characteristics as well as synergized anticancer activities

2020 ◽  
Vol 44 (37) ◽  
pp. 15994-16005
Author(s):  
Yue-Ming Yu ◽  
Ming-Chao Yu ◽  
Ling-Yang Wang ◽  
Yan-Tuan Li ◽  
Zhi-Yong Wu ◽  
...  
Keyword(s):  
Syringic Acid ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Supramolecular Adduct

The in vitro and in vivo properties as well as synergistic antitumor activities of the first tegafur-nutraceutical cocrystal are reported.

scholarly journals Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents

2013 ◽  
Vol 78 (9) ◽  
pp. 1301-1308 ◽  
Author(s):  
Lin Luo ◽  
Jiang-Ke Qin ◽  
Zhi-Kai Dai ◽  
Shi-Hua Gao
Keyword(s):  
Cell Lines ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Structural Factors ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Human Solid Tumor ◽  
Synthesis And Biological Evaluation

Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships.

Mixed-Ligand Cu(II) Carboxylates: Synthesis, Crystal Structure, FTIR, DNA Binding, Antidiabetic, and Anti-Alzheimer’s Studies

2019 ◽  
Vol 64 (11) ◽  
pp. 1365-1378 ◽  
Author(s):  
Afifa Mushtaq ◽  
Saqib Ali ◽  
Muhammad Nawaz Tahir ◽  
Ali Haider ◽  
Hammad Ismail ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Mixed Ligand
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