Synthesis, structures, DNA-binding and anticancer activities of some copper(I)-phosphine complexes

Polyhedron ◽  
2019 ◽  
Vol 158 ◽  
pp. 164-172 ◽  
Author(s):  
Khlood H. Mashat ◽  
Bandar A. Babgi ◽  
Mostafa A. Hussien ◽  
Muhammad Nadeem Arshad ◽  
Magda H. Abdellattif
Keyword(s):  
Dna Binding ◽  
Anticancer Activities ◽  
Phosphine Complexes

scholarly journals DNA-Binding and Topoisomerase-I-Suppressing Activities of Novel Vanadium Compound Van-7

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Xiao-mei Mo ◽  
Zhan-fang Chen ◽  
Xin Qi ◽  
Yan-tuan Li ◽  
Jing Li
Keyword(s):  
Dna Binding ◽  
Anticancer Agents ◽  
Topoisomerase I ◽  
A549 Cells ◽  
Anticancer Activities ◽  
Vanadium Compound ◽  
New Class ◽  
M Phase ◽  
Low Toxicity ◽  
Topo Ii

Vanadium compounds were studied during recent years to be considered as a representative of a new class of nonplatinum metal anticancer agents in combination to its low toxicity. Here, we found a vanadium compound Van-7 as an inhibitor of Topo I other than Topo II using topoisomerase-mediated supercoiled DNA relaxation assay. Agarose gel electrophoresis and comet assay showed that Van-7 treatment did not produce cleavable complexes like HCPT, thereby suggesting that Topo I inhibition occurred upstream of the relegation step. Further studies revealed that Van-7 inhibited Topo I DNA binding involved in its intercalating DNA. Van-7 did not affect the catalytic activity of DNase I even up to100 μM. Van-7 significantly suppressed the growth of cancer cell lines with IC50at nanomolar concentrations and arrested cell cycle of A549 cells at G2/M phase. All these results indicate that Van-7 is a potential selective Topo I inhibitor with anticancer activities as a kind of Topo I suppressor, not Topo I poison.

Gold(i) and gold(iii) phosphine complexes: synthesis, anticancer activities towards 2D and 3D cancer models, and apoptosis inducing properties

2018 ◽  
Vol 47 (43) ◽  
pp. 15312-15323 ◽  
Author(s):  
T. Srinivasa Reddy ◽  
Steven H. Privér ◽  
Vijay V. Rao ◽  
Nedaossadat Mirzadeh ◽  
Suresh K. Bhargava
Keyword(s):  
Anticancer Activity ◽  
Anticancer Activities ◽  
Phosphine Complexes ◽  
Cancer Models ◽  
2D And 3D

Herein we report the synthesis of gold(i) and gold(iii) complexes of tris(4-methoxyphenyl)phosphine and tris(2,6-dimethoxyphenyl)phosphine and their anticancer activity towards 2D and 3D cancer models.

Spectroscopic and In Silico DNA Binding Studies on the Interaction of Some New N-Substituted Rhodanines with Calf-thymus DNA: In Vitro Anticancer Activities

2019 ◽  
Vol 19 (3) ◽  
pp. 425-433 ◽  
Author(s):  
Imran Ali ◽  
Mohammad N. Lone ◽  
Zeid A. Alothman ◽  
Ahmad Y. Badjah ◽  
Abdullah G. Alanazi
Keyword(s):  
Dna Binding ◽  
Anticancer Agents ◽  
In Silico ◽  
Calf Thymus Dna ◽  
Black Dot ◽  
Anticancer Activities ◽  
Binding Studies ◽  
Molecular Docking Study ◽  
Calf Thymus ◽  
Dna Binding Studies

Background: In this era of science, cancer is a black dot on the face of humankind. Consequently, the search of promising anticancer agents continues. Aims: Here we designed and synthesized new N-substituted rhodanines (RD1-7), evaluated their multispectroscopic interaction with calf thymus DNA, in silico and anticancer studies against MDA-MB-231cancer cell line. Methods: By MTT assay rhodanine RD1 was found to be the most potent with IC50 value of 72.61 μM. In addition, DNA binding studies (UV-vis and fluorescence) revealed strong binding affinity of RD1-7 with DNA (Kb in the range of 1.5-7.4 × 105 M-1). Moreover, molecular docking study, experimental DNA binding and anticancer studies are all well agreed to each other. Results: It was observed that H-bonding and hydrophobic attractions were responsible for stability of DNAcompound adducts. Besides, the reported rhodanines (RD1-7) were found as minor groove binders of DNA. Concisely, RD1-7 indicated promising pharmacological properties and hence, shows auspicious future for the development of novel anticancer agents. Conclusion: The reported rhodanines showed excellent anticancer properties. Therefore, the described rhodanines may be used as potential anticancer agents in the future.

Two new mixed copper(ii)–dipeptide complexes of N,N-donor heterocycle ligands: studies on their non-covalent DNA binding, chemical nuclease, antioxidant and anticancer activities

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35952-35965 ◽  
Author(s):  
Qian Gan ◽  
Chun-Lian Zhang ◽  
Bing-Feng Wang ◽  
Ya-Hong Xiong ◽  
Yin-Lian Fu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Dna Interactions ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Chemical Nuclease

Two novel mononuclear mixed ligand copper(ii)-dipeptide complexes have been synthesized. The DNA interactions of the complexes were investigated. In addition, the antioxidant and antitumor activities of the complexes were evaluated.

scholarly journals Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh3)2(4,6-Dimethyl-2-Thiopyrimidine-κS]

Crystals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 688
Author(s):  
Bandar A. Babgi ◽  
Jalal H. Alsayari ◽  
Bambar Davaasuren ◽  
Abdul-Hamid Emwas ◽  
Mariusz Jaremko ◽  
...  
Keyword(s):  
Cancer Cell Line ◽  
Symmetry Operation ◽  
Anticancer Activities ◽  
Centrosymmetric Dimer ◽  
Anticancer Properties ◽  
Phosphine Complexes ◽  
Hela Cell Lines ◽  
Copper Center ◽  
A Domains ◽  
Intramolecular Hydrogen

CuBr(PPh3)2(4,6-dimethylpyrimidine-2-thione) (Cu-L) was synthesized by stirring CuBr(PPh3)3 and 4,6-dimethylpyrimidine-2-thione in dichloromethane. The crystal structure of Cu-L was obtained, and indicated that the complex adopts a distorted tetrahedral structure with several intramolecular hydrogen bonds. Moreover, a centrosymmetric dimer is formed by the intermolecular hydrogen bonding of the bromine acceptor created by symmetry operation 1−x, 1−y, 1−z to the methyl group (D3 = C42) of the pyrimidine–thione ligand. HSA-binding of Cu-L and its ligand were evaluated, revealing that Cu-L binds to HSA differently than its ligand. The HSA-bindings were modeled by molecular docking, which suggested that Cu-L binds to the II A domain while L binds between the I B and II A domains. Anticancer activities toward OVCAR-3 and HeLa cell lines were tested and indicated the significance of the copper center in enhancing the cytotoxic effect; negligible toxicities for L and Cu-L were observed towards a non-cancer cell line. The current study highlights the potential of copper(I)-phosphine complexes containing thione ligands as therapeutic agents.

Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds

2013 ◽  
Vol 23 (24) ◽  
pp. 6854-6859 ◽  
Author(s):  
Chung-Yu Chen ◽  
Pei-Hua Lee ◽  
Yong-Yong Lin ◽  
Wen-Ting Yu ◽  
Wan-Ping Hu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activities ◽  
Hybrid Scaffolds

Synthesis, Characterization, DNA Interaction Study, Antibacterial and Anticancer Activities of New Palladium(II) Phosphine Complexes

2018 ◽  
Vol 88 (3) ◽  
pp. 551-559 ◽  
Author(s):  
I. Aziz ◽  
M. Sirajuddin ◽  
A. Munir ◽  
S. A. Tirmizi ◽  
S. Nadeem ◽  
...  
Keyword(s):  
Dna Interaction ◽  
Interaction Study ◽  
Anticancer Activities ◽  
Phosphine Complexes

Copper(ii) complexes with NNO ligands: synthesis, crystal structures, DNA cleavage, and anticancer activities

2019 ◽  
Vol 48 (48) ◽  
pp. 17925-17935 ◽  
Author(s):  
Ping Yang ◽  
Dan-Dan Zhang ◽  
Zi-Zhou Wang ◽  
Hui-Zhong Liu ◽  
Qing-Shan Shi ◽  
...  
Keyword(s):  
Dna Binding ◽  
Crystal Structures ◽  
Binding Affinity ◽  
Dna Cleavage ◽  
Anticancer Activities ◽  
Dna Binding Affinity

The copper(ii) complexes of aroylhydrazone ligands exhibit strong DNA binding affinity and prominent ds DNA cleavage and cytotoxicity.

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