Controlling the resolution and duration of pulsatile release from injectable magnetic ‘plum-pudding’ nanocomposite hydrogels

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15770-15781 ◽  
Author(s):  
Danielle Maitland ◽  
Scott B. Campbell ◽  
Jenny Chen ◽  
Todd Hoare
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Pore Space ◽  
Alternating Magnetic Field ◽  
Injectable Hydrogel ◽  
Pulsatile Release ◽  
Nanocomposite Hydrogels ◽  
Hydrogel Nanocomposites ◽  
Thermosensitive Microgels

Injectable hydrogel nanocomposites with entrapped SPIONs, thermosensitive microgels, and model drugs generate heat when an alternating magnetic field is applied, causing the microgels to deswell and create pore space to promote enhanced drug release.

Extremely low frequency alternating magnetic field–triggered and MRI–traced drug delivery by optimized magnetic zeolitic imidazolate framework-90 nanoparticles

Nanoscale ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 3259-3263 ◽  
Author(s):  
Jie Fang ◽  
Yong Yang ◽  
Wen Xiao ◽  
Bingwen Zheng ◽  
Yun-Bo Lv ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Low Frequency ◽  
Alternating Magnetic Field ◽  
Zeolitic Imidazolate Framework ◽  
Extremely Low Frequency

An extremely low frequency alternating magnetic field of 20 Hz was proved to be able to remarkably accelerate the drug release from optimized ZIF-90 nanospheres with incorporated Fe3O4 nanoparticles acting as actuator.

scholarly journals Fluorescent magnetosomes for controlled and repetitive drug release under the application of an alternating magnetic field under conditions of limited temperature increase (<2.5 °C)

Nanoscale ◽  
2018 ◽  
Vol 10 (23) ◽  
pp. 10918-10933 ◽  
Author(s):  
Edouard Alphandéry ◽  
Darine Abi Haidar ◽  
Olivier Seksek ◽  
François Guyot ◽  
Imène Chebbi
Keyword(s):  
Magnetic Field ◽  
Antitumor Activity ◽  
Drug Release ◽  
Temperature Increase ◽  
Alternating Magnetic Field ◽  
Limited Temperature ◽  
External Sources

Therapeutic substances bound to nanoparticles have been shown to dissociate following excitation by various external sources of energies or chemical disturbance, resulting in controllable and efficient antitumor activity.

Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

2014 ◽  
Vol 5 (10) ◽  
pp. 3311-3315 ◽  
Author(s):  
Alexander E. Dunn ◽  
Douglas J. Dunn ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Tim Stait-Gardner ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Alternating Magnetic Field ◽  
Temporal Control ◽  
Delivery Platform

A novel theranostic controlled drug delivery platform that binds the drug to the nanocarrier by utilising Schiff base bonds to achieve high spatial and temporal control over drug release.

scholarly journals Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3637
Author(s):  
Koichiro Hayashi ◽  
Atsuto Tokuda ◽  
Jin Nakamura ◽  
Ayae Sugawara-Narutaki ◽  
Chikara Ohtsuki
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Heat Generation ◽  
Culture Medium ◽  
Surgical Repair ◽  
Thermal Therapy ◽  
Alternating Magnetic Field ◽  
Medium Temperature ◽  
Exogenous Trigger ◽  
Tissue Defects

Tearable and fillable implants are used to facilitate surgery. The use of implants that can generate heat and release a drug in response to an exogenous trigger, such as an alternating magnetic field (AMF), can facilitate on-demand combined thermal treatment and chemotherapy via remote operation. In this study, we fabricated tearable sponges composed of collagen, magnetite nanoparticles, and anticancer drugs. Crosslinking of the sponges by heating for 6 h completely suppressed undesirable drug release in saline at 37 °C but allowed drug release at 45 °C. The sponges generated heat immediately after AMF application and raised the cell culture medium temperature from 37 to 45 °C within 15 min. Heat generation was controlled by switching the AMF on and off. Furthermore, in response to heat generation, drug release from the sponges could be induced and moderated. Thus, remote-controlled heat generation and drug release were achieved by switching the AMF on and off. The sponges destroyed tumor cells when AMF was applied for 15 min but not when AMF was absent. The tearing and filling properties of the sponges may be useful for the surgical repair of bone and tissue defects. Moreover, these sponges, along with AMF application, can facilitate combined thermal therapy and chemotherapy.

Assembly-Induced Thermogenesis of Gold Nanoparticles in the Presence of Alternating Magnetic Field for Controllable Drug Release of Hydrogel

2016 ◽  
Vol 28 (48) ◽  
pp. 10801-10808 ◽  
Author(s):  
Peng Wang ◽  
Jianfei Sun ◽  
Zhichao Lou ◽  
Fengguo Fan ◽  
Ke Hu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Alternating Magnetic Field

scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

AMF responsive DOX-loaded magnetic microspheres: transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer

2018 ◽  
Vol 6 (15) ◽  
pp. 2289-2303 ◽  
Author(s):  
Weiming Xue ◽  
Xiao-Li Liu ◽  
Heping Ma ◽  
Wensheng Xie ◽  
Saipeng Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Cancer Therapy ◽  
Drug Release ◽  
Alternating Magnetic Field ◽  
Magnetic Microspheres ◽  
Release Mechanism ◽  
Chitosan Microspheres ◽  
Drug Release Mechanism

DOX-loaded magnetic alginate–chitosan microspheres were developed to evaluate alternating magnetic field-responsive, synergistic chemo-thermal cancer therapy.

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