Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

2014 ◽  
Vol 5 (10) ◽  
pp. 3311-3315 ◽  
Author(s):  
Alexander E. Dunn ◽  
Douglas J. Dunn ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Tim Stait-Gardner ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Alternating Magnetic Field ◽  
Temporal Control ◽  
Delivery Platform

A novel theranostic controlled drug delivery platform that binds the drug to the nanocarrier by utilising Schiff base bonds to achieve high spatial and temporal control over drug release.

Extremely low frequency alternating magnetic field–triggered and MRI–traced drug delivery by optimized magnetic zeolitic imidazolate framework-90 nanoparticles

Nanoscale ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 3259-3263 ◽  
Author(s):  
Jie Fang ◽  
Yong Yang ◽  
Wen Xiao ◽  
Bingwen Zheng ◽  
Yun-Bo Lv ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Low Frequency ◽  
Alternating Magnetic Field ◽  
Zeolitic Imidazolate Framework ◽  
Extremely Low Frequency

An extremely low frequency alternating magnetic field of 20 Hz was proved to be able to remarkably accelerate the drug release from optimized ZIF-90 nanospheres with incorporated Fe3O4 nanoparticles acting as actuator.

Controlled drug delivery for cancer cell treatment via magnetic doxorubicin imprinted silica nanoparticles

2020 ◽  
Vol 56 (70) ◽  
pp. 10255-10258 ◽  
Author(s):  
Maria Nerantzaki ◽  
Aude Michel ◽  
Emmanuel Briot ◽  
Jean Michel Siaugue ◽  
Christine Ménager ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Controlled Drug Delivery ◽  
Alternating Magnetic Field ◽  
Doxorubicin Release

Magnetic doxorubicin imprinted silica nanoparticles for remotely triggered doxorubicin release upon applying an alternating magnetic field.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

Dual-pH/Magnetic-Field-Controlled Drug Delivery Systems Based on Fe3 O4 @SiO2 -Incorporated Salecan Graft Copolymer Composite Hydrogels

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1600-1609 ◽  
Author(s):  
Xinyu Hu ◽  
Yongmei Wang ◽  
Liangliang Zhang ◽  
Man Xu ◽  
Jianfa Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Graft Copolymer ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Composite Hydrogels

Evaluation of clay-ionene nanocomposite carriers for controlled drug delivery: Synthesis, in vitro drug release, and kinetics

2019 ◽  
Vol 225 ◽  
pp. 122-132 ◽  
Author(s):  
Hany El-Hamshary ◽  
Mohamed H. El-Newehy ◽  
Meera Moydeen Abdulhameed ◽  
Ayman El-Faham ◽  
Abeer S. Elsherbiny
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
In Vitro Drug Release

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

scholarly journals Magnetic micropump embedded in contact lens for on-demand drug delivery

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Wang ◽  
Jungyul Park
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Drug Release ◽  
Contact Lens ◽  
Tear Film ◽  
Check Valve ◽  
Drug Diffusion ◽  
On Demand ◽  
The Magnetic Field

AbstractIn this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized.

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