Tumor-targeted docetaxel-loaded hyaluronic acid-quercetin polymeric micelles with p-gp inhibitory property for hepatic cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (33) ◽  
pp. 27542-27556 ◽  
Author(s):  
Chenfeng Xu ◽  
Yu Ding ◽  
Jiang Ni ◽  
Lifang Yin ◽  
Jianping Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Therapeutic Efficacy ◽  
Polymeric Micelles ◽  
Hepatic Cancer ◽  
Efflux Inhibition ◽  
Targeted Drug

Herein, a novel targeted drug delivery nanosystem based on hyaluronic acid (HA) and quercetin (QU) was designed to improve the in vivo therapeutic efficacy of DTX on HC through HA-CD44 mediated targeting and QU-based p-gp efflux inhibition.

Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (21) ◽  
pp. 5273-5280 ◽  
Author(s):  
Hong Yeol Yoon ◽  
Heebeom Koo ◽  
Ki Young Choi ◽  
Ick Chan Kwon ◽  
Kuiwon Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Improved Stability ◽  
Targeted Drug

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations

2013 ◽  
Vol 5 (15) ◽  
pp. 6909-6914 ◽  
Author(s):  
Guodong Liu ◽  
He Shen ◽  
Jinning Mao ◽  
Liming Zhang ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

2019 ◽  
pp. 173-204 ◽  
Author(s):  
Mahadevappa Y. Kariduraganavar ◽  
Geetha B. Heggannavar ◽  
Sandra Amado ◽  
Geoffrey R. Mitchell
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Targeted Drug
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