Fluorescent protein-reactive polymers via one-pot combination of the Ugi reaction and RAFT polymerization

2016 ◽  
Vol 7 (30) ◽  
pp. 4867-4872 ◽  
Author(s):  
Haibo Wu ◽  
Bin Yang ◽  
Yuan Zhao ◽  
Yen Wei ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Fluorescent Protein ◽  
Raft Polymerization ◽  
Ugi Reaction ◽  
One Pot ◽  
Reactive Polymers ◽  
Reactive Groups ◽  
The One

Well-defined polymers containing both fluorescent and protein-reactive groups at the chain end have been facilely synthesized by the one-pot combination of the four-component Ugi reaction and RAFT polymerization.

Application of the Ugi Reaction for the One-Pot Synthesis of Uracil Polyoxin C Analogues

2009 ◽  
Vol 74 (13) ◽  
pp. 4870-4873 ◽  
Author(s):  
Andrew Plant ◽  
Peter Thompson ◽  
David M. Williams
Keyword(s):  
Ugi Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

One pot synthesis of higher order quasi-block copolymer librariesviasequential RAFT polymerization in an automated synthesizer

2014 ◽  
Vol 5 (18) ◽  
pp. 5236-5246 ◽  
Author(s):  
Joris J. Haven ◽  
Carlos Guerrero-Sanchez ◽  
Daniel J. Keddie ◽  
Graeme Moad ◽  
San H. Thang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
High Throughput ◽  
Raft Polymerization ◽  
Functional Polymers ◽  
Higher Order ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

The utility of automated high-throughput methods for the one pot synthesis of functional polymers of increased complexity is reported.

ChemInform Abstract: Investigation of the One-Pot Synthesis of Quinolin-2-(1H)-ones and the Discovery of a Variation of the Three-Component Ugi Reaction.

ChemInform ◽  
2011 ◽  
Vol 42 (27) ◽  
pp. no-no
Author(s):  
Christopher P. Gordon ◽  
Kelly A. Young ◽  
Lacey Hizartzidis ◽  
Fiona M. Deane ◽  
Adam McCluskey
Keyword(s):  
Ugi Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

The power of one-pot: a hexa-component system containing π–π stacking, Ugi reaction and RAFT polymerization for simple polymer conjugation on carbon nanotubes

2015 ◽  
Vol 6 (4) ◽  
pp. 509-513 ◽  
Author(s):  
Bin Yang ◽  
Yuan Zhao ◽  
Xu Ren ◽  
Xiaoyong Zhang ◽  
Changkui Fu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ugi Reaction ◽  
Polymer Modification ◽  
One Pot ◽  
Component System ◽  
Π Stacking ◽  
Polymer Conjugation

Ugi reaction has been recognized as a multicomponent click reaction to construct a hexa-component one-pot system with π–π stacking and RAFT polymerization for the simple (co)polymer modification of CNT surfaces.

Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction

2011 ◽  
Vol 9 (5) ◽  
pp. 1419 ◽  
Author(s):  
Christopher P. Gordon ◽  
Kelly A. Young ◽  
Lacey Hizartzidis ◽  
Fiona M. Deane ◽  
Adam McCluskey
Keyword(s):  
Ugi Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

scholarly journals Anionic and neutral 2D indium metal–organic frameworks as catalysts for the Ugi one-pot multicomponent reaction

2019 ◽  
Vol 48 (9) ◽  
pp. 2988-2995 ◽  
Author(s):  
Daniel Reinares-Fisac ◽  
Lina M Aguirre-Díaz ◽  
Marta Iglesias ◽  
Enrique Gutiérrez-Puebla ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Multicomponent Reaction ◽  
Layered Structure ◽  
Metal Organic Frameworks ◽  
Ugi Reaction ◽  
One Pot ◽  
Metal Organic ◽  
Indium Metal ◽  
The One

Two metal–organic frameworks (MOFs) made of indium and 1,3,5-tris(4-carboxyphenyl)benzene and having a layered structure have been synthesized, showing catalytic activity in the one-pot Ugi reaction.

Application of Saccharin as an Acidic Partner in the Ugi Reaction for the One-Pot Synthesis of 3-Iminosaccharins

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1214-1218 ◽  
Author(s):  
Sorour Ramezanpour ◽  
Zahra Bigdeli ◽  
Nahid Alavijeh ◽  
Frank Rominger
Keyword(s):  
Carboxylic Acid ◽  
Ugi Reaction ◽  
One Pot ◽  
Acid Component ◽  
Multicomponent Condensation ◽  
One Pot Synthesis ◽  
The One ◽  
First Time

The use of saccharin as a replacement for the carboxylic acid component in an Ugi multicomponent condensation leading to [(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]acetamide (3-iminosaccharin) derivatives is described for the first time.

Facile 'One-Pot' Preparation of Reversible, Disulfide-Containing Shell Cross-Linked Micelles from a RAFT-Synthesized, pH-Responsive Triblock Copolymer in Water at Room Temperature

2009 ◽  
Vol 62 (11) ◽  
pp. 1520 ◽  
Author(s):  
Xuewei Xu ◽  
Adam E. Smith ◽  
Charles L. McCormick
Keyword(s):  
Triblock Copolymer ◽  
Room Temperature ◽  
Raft Polymerization ◽  
Hydrodynamic Diameter ◽  
Ph Responsive ◽  
Solution Ph ◽  
One Pot ◽  
Simultaneous Formation ◽  
Bioactive Agents ◽  
The One

A pH-responsive triblock copolymer, α-methoxy poly(ethylene oxide)-b-poly(N-(3-aminopropyl) methacrylamide)-β-poly(2-(diisopropylamino)ethyl methacrylate) (mPEO-PAPMA-PDPAEMA), was synthesized via aqueous RAFT polymerization. This triblock copolymer dissolves in aqueous solution at low pH (<5.0) due to protonation of primary amine residues on the PAPMA block and tertiary amine residues on the PDPAEMA block. Above pH 6.0, the copolymer unimers self-assemble into micelles consisting of PDPAEMA cores, PAPMA shells, and mPEO coronas. Dynamic light scattering studies indicated a hydrodynamic diameter of 92 nm at pH 9.0. A bifunctional, reversible cross-linker, dimethyl 3,3′-dithiobispropionimidate (DTBP), was used to cross-link the micelles. The ‘one-pot’ formation of shell cross-linked (SCL) micelles was accomplished at room temperature in water by mixing the triblock copolymers and DTBP at pH 3.0, and slowly increasing the solution pH to 9.0 leading to the simultaneous formation of micelles and cross-linking. These SCL micelles are readily cleaved by the addition of the reducing agent, dithiothreitol, and can be re-cross-linked simply by exposure to air. Such SCL micelles have potential as nanocarriers for controlled release of therapeutic and diagnostic agents because the in situ cleavage of the disulfide linkages would not only allow release of bioactive agents, but also permit renal clearance of the resulting unimeric components.

A Series of Metal-Organic Frameworks for Selective CO2 Capture and Catalytic Oxidative Carboxylation of Olefins

2018 ◽  
Author(s):  
Huong T. D. Nguyen ◽  
Y B. N. Tran ◽  
Hung N. Nguyen ◽  
Tranh C. Nguyen ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Room Temperature ◽  
Gas Adsorption ◽  
New Materials ◽  
One Pot ◽  
Acid Gas ◽  
Naphthalene Diimide ◽  
Styrene Carbonate ◽  
Metal Organic ◽  
Adsorption Of Co ◽  
The One

<p>Three novel lanthanide metal˗organic frameworks (Ln-MOFs), namely MOF-590, -591, and -592 were constructed from a naphthalene diimide tetracarboxylic acid. Gas adsorption measurements of MOF-591 and -592 revealed good adsorption of CO<sub>2</sub> (low pressure, at room temperature) and moderate CO<sub>2</sub> selectivity over N<sub>2</sub> and CH<sub>4</sub>. Accordingly, breakthrough measurements were performed on a representative MOF-592, in which the separation of CO<sub>2</sub> from binary mixture containing N<sub>2</sub> and CO<sub>2</sub> was demonstrated without any loss in performance over three consecutive cycles. Moreover, MOF-590, MOF-591, and MOF-592 exhibited catalytic activity in the one-pot synthesis of styrene carbonate from styrene and CO<sub>2</sub> under mild conditions (1 atm CO<sub>2</sub>, 80 °C, and solvent-free). Among the new materials, MOF-590 revealed a remarkable efficiency with exceptional conversion (96%), selectivity (95%), and yield (91%). </p><br>

Structural Evidence of Photoisomerization Pathways in Fluorescent Proteins

2019 ◽  
Author(s):  
Jeffrey Chang ◽  
Matthew Romei ◽  
Steven Boxer
Keyword(s):  
Rational Design ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Super Resolution ◽  
Unit Cell Size ◽  
Chlorine Substituent ◽  
Gfp Chromophore ◽  
The One ◽  
Green Fluorescent ◽  
Super Resolution Microscopy

<p>Double-bond photoisomerization in molecules such as the green fluorescent protein (GFP) chromophore can occur either via a volume-demanding one-bond-flip pathway or via a volume-conserving hula-twist pathway. Understanding the factors that determine the pathway of photoisomerization would inform the rational design of photoswitchable GFPs as improved tools for super-resolution microscopy. In this communication, we reveal the photoisomerization pathway of a photoswitchable GFP, rsEGFP2, by solving crystal structures of <i>cis</i> and <i>trans</i> rsEGFP2 containing a monochlorinated chromophore. The position of the chlorine substituent in the <i>trans</i> state breaks the symmetry of the phenolate ring of the chromophore and allows us to distinguish the two pathways. Surprisingly, we find that the pathway depends on the arrangement of protein monomers within the crystal lattice: in a looser packing, the one-bond-flip occurs, whereas in a tighter packing (7% smaller unit cell size), the hula-twist occurs.</p><p> </p><p> </p><p> </p><p> </p><p> </p><p> </p> <p> </p>

Sign in / Sign up

Export Citation Format

Share Document