scholarly journals Well-defined (co)polypeptides bearing pendant alkyne groups

2016 ◽  
Vol 7 (21) ◽  
pp. 3487-3491 ◽  
Author(s):  
Wei Zhao ◽  
Yves Gnanou ◽  
Nikos Hadjichristidis
Keyword(s):  
Amino Acids ◽  
Hydrogen Bonding ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Metal Free

A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of alkyne-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups.

Synthesis of metal-free poly(1,4-dioxan-2-one) by enzyme-catalyzed ring-opening polymerization

2000 ◽  
Vol 38 (9) ◽  
pp. 1560-1567 ◽  
Author(s):  
Haruo Nishida ◽  
Mitsuhiro Yamashita ◽  
Masumi Nagashima ◽  
Takeshi Endo ◽  
Yutaka Tokiwa
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Metal Free

Biodegradable Polymers Derived from Amino Acids for Biological Applications

2010 ◽  
Vol 76 ◽  
pp. 30-35 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Ilanit Hagag ◽  
Michal Kolitz ◽  
Abraham J. Domb ◽  
Jeoshua Katzhendler
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Microwave Assisted Synthesis ◽  
Hydroxy Acids ◽  
Natural Amino Acids ◽  
Direct Condensation ◽  
Positively Charged

Optically active α-hydroxy acids derived from amino acids have been synthesized and polymerized into new biodegradable polyesters. The variety of functional side chains enables the design of positively charged, negatively charged, hydrophobic and hydrophilic chiral building blocks or any combination of these constituents. Hydroxy acids of 15 natural amino acids were prepared with retention of configuration using a straightforward and reliable method of diazotization of α-amino acids. Polyesters were synthesized from these hydroxy acids by a number of methods: direct condensation in bulk, microwave assisted synthesis and ring opening polymerization. The molecular weight of the prepared polymers ranges between 2000 to 5000Da for the direct condensation and the microwave methods, whereas the ring opening polymerization results in high molecular weight polymers (20000 to 30000Da). The polymers were analyzed for their optical activity (Circular Dichroism Spectroscopy), thermal properties (DSC), solubility, molecular weight and polydispersity (GPC), and aqueous degradation. These polymers were tested for their compatibility to neuronal cells growth and differentiation.

Phosphazene-Promoted Metal-Free Ring-Opening Polymerization of 1,2-Epoxybutane Initiated by Secondary Amides

2015 ◽  
Vol 48 (21) ◽  
pp. 7755-7764 ◽  
Author(s):  
Laetitia Dentzer ◽  
Caroline Bray ◽  
Sylvie Noinville ◽  
Nicolas Illy ◽  
Philippe Guégan
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Free Ring ◽  
Metal Free ◽  
Secondary Amides

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

2020 ◽  
Vol 49 (14) ◽  
pp. 4737-4834 ◽  
Author(s):  
Alicia Rasines Mazo ◽  
Stephanie Allison-Logan ◽  
Fatemeh Karimi ◽  
Nicholas Jun-An Chan ◽  
Wenlian Qiu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Architectural Design ◽  
Ring Opening Polymerization ◽  
Comprehensive Overview

This review provides a comprehensive overview of the latest advances in the synthesis, architectural design and biomedical applications of polypeptides and their hybrids.

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