Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

2016 ◽  
Vol 15 (8) ◽  
pp. 1020-1028 ◽  
Author(s):  
Eugènia Agut-Busquet ◽  
Jorge Romaní ◽  
Yolanda Gilaberte ◽  
Ana García-Malinis ◽  
Miquel Ribera-Pibernat ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Hidradenitis Suppurativa ◽  
Light Emitting Diode ◽  
The Body ◽  
Review Of The Literature ◽  
Inflammatory Skin Disease ◽  
Light Emitting ◽  
Follow Up Study

Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body.

scholarly journals Topical and Intradermal Efficacy of Photodynamic Therapy with Methylene Blue and Light-Emitting Diode in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis

2015 ◽  
Vol 6 (3) ◽  
pp. 106-111 ◽  
Author(s):  
Mônica Raquel Sbeghen ◽  
Evandra Maria Voltarelli ◽  
Tácito Graminha Campois ◽  
Elza Kimura ◽  
Sandra Mara Alessi Aristides ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cutaneous Leishmaniasis ◽  
Light Emitting Diode ◽  
Leishmania Braziliensis ◽  
Light Emitting

scholarly journals Comparative evaluation of photodynamic therapy using LASER or light emitting diode on cariogenic bacteria: An in vitro study

2014 ◽  
Vol 08 (04) ◽  
pp. 509-514 ◽  
Author(s):  
Liliana Guimarães Oliveira Ricatto ◽  
Luis Augusto Lopato Conrado ◽  
Cecilia Pedroso Turssi ◽  
Fabiana Mantovani Gomes França ◽  
Roberta Tarkany Basting ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
In Vitro Study ◽  
Antimicrobial Effect ◽  
Dye Laser ◽  
Laser Application ◽  
Light Emitting ◽  
Cariogenic Bacteria

ABSTRACT Objective: The aim of this study was to evaluate in vitro the effect of photodynamic therapy (PDT) using LASER or light emitting diode (LED) on cariogenic bacteria (Streptococcus mutans [SM] and Lactobacillus casei [LC]) in bovine dentin. Materials and Methods: Twenty five fragments of dentin were contaminated with SM and LC strands and divided into five experimental groups according to the therapy they received (n = 5): C – control (no treatment), SCLED – no dye/LED application (94 J/cm2), SCLASER – no dye/LASER application (94 J/cm2), CCLED – dye/LED application (94 J/cm2) and CCLASER – dye/LASER application (94 J/cm2). The dye used was methylene blue at 10 mM. Dentin scrapes were harvested from each fragment and prepared for counts of colony forming units (CFU)/mL. The data were analyzed using Kruskal–Wallis, followed by Student–Newman–Keuls (⍺ =0.05). Results: Regarding SM, groups CCLASER and CCLED showed a significant reduction in CFU/mL, which was statistically superior to the SCLASER, SCLED and C groups. Regarding LC, the groups CCLASER and CCLED caused a significant reduction in CFU/mL when compared with SCLASER, which showed intermediate values. SCLED and C had a lesser effect on reducing CFU/mL, where the former showed values similar to those of SCLASER. Conclusions: In conclusion, PDT combined with LASER or LED and methylene blue had a significant antimicrobial effect on cariogenic bacteria in the dentin.

scholarly journals In Vitro Effect of Photodynamic Therapy with Different Lights and Combined or Uncombined with Chlorhexidine on Candida spp.

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1176
Author(s):  
Vanesa Pérez-Laguna ◽  
Yolanda Barrena-López ◽  
Yolanda Gilaberte ◽  
Antonio Rezusta
Keyword(s):  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
Antimicrobial Effect ◽  
Photodynamic Treatment ◽  
Candida Spp ◽  
Promising Alternative ◽  
Light Emitting ◽  
Colony Forming Units ◽  
Vitro Effect

Candidiasis is very common and complicated to treat in some cases due to increased resistance to antifungals. Antimicrobial photodynamic therapy (aPDT) is a promising alternative treatment. It is based on the principle that light of a specific wavelength activates a photosensitizer molecule resulting in the generation of reactive oxygen species that are able to kill pathogens. The aim here is the in vitro photoinactivation of three strains of Candida spp., Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019 and Candida krusei ATCC 6258, using aPDT with different sources of irradiation and the photosensitizer methylene blue (MB), alone or in combination with chlorhexidine (CHX). Irradiation was carried out at a fluence of 18 J/cm2 with a light-emitting diode (LED) lamp emitting in red (625 nm) or a white metal halide lamp (WMH) that emits at broad-spectrum white light (420–700 nm). After the photodynamic treatment, the antimicrobial effect is evaluated by counting colony forming units (CFU). MB-aPDT produces a 6 log10 reduction in the number of CFU/100 μL of Candida spp., and the combination with CHX enhances the effect of photoinactivation (effect achieved with lower concentration of MB). Both lamps have similar efficiencies, but the WMH lamp is slightly more efficient. This work opens the doors to a possible clinical application of the combination for resistant or persistent forms of Candida infections.

scholarly journals New perspectives on the treatment of hidradenitis suppurativa

2021 ◽  
Vol 12 ◽  
pp. 204062232110559
Author(s):  
Victoria Amat-Samaranch ◽  
Eugènia Agut-Busquet ◽  
Eva Vilarrasa ◽  
Lluís Puig
Keyword(s):  
Hidradenitis Suppurativa ◽  
Topical Therapy ◽  
Clinical Manifestations ◽  
Light Therapy ◽  
The Body ◽  
Biologic Agent ◽  
Inflammatory Skin Disease ◽  
Randomized Controlled ◽  
Modifying Factors ◽  
Systemic Treatments

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the presence of painful nodules, abscesses, chronically draining fistulas, and scarring in apocrine gland-bearing areas of the body. The exact pathogenesis of HS is not yet well understood, but there is a consensus in considering HS a multifactorial disease with a genetic predisposition, an inflammatory dysregulation, and an influence of environmental modifying factors. Therapeutic approach of HS is challenging due to the wide clinical manifestations of the disease and the complex pathogenesis. This review describes evidence for effectiveness of current and emerging HS therapies. Topical therapy, systemic treatments, biological agents, surgery, and light therapy have been used for HS with variable results. Adalimumab is the only US Food and Drug Administration (FDA) approved biologic agent for moderate-to-severe HS, but new therapeutic options are being studied, targeting different specific cytokines involved in HS pathogenesis. Comparing treatment outcomes between therapies is difficult due to the lack of randomized controlled trials. Treatment strategy should be selected in concordance to disease severity and requires combination of treatments in most cases.

THE RHEUMATIC CHILD AND HIS WORLD

PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 916-922
Author(s):  
Iago Galdston
Keyword(s):  
Rheumatic Fever ◽  
External World ◽  
The Body ◽  
Statistical Analyses ◽  
Review Of The Literature ◽  
Question Asking ◽  
Claude Bernard ◽  
The World ◽  
Etiologic Research

IT IS PROVERBIAL that a fool can ask more questions than a wise man can answer. It is not proverbial that for the question-asking fool there is some hope and for the others, none. Now it is my intention on this occasion to play the fool awhile, to ask a great number of questions, and I cordially invite you to join me in this game. I want to inquire into The World of the Rheumatic Child, into his internal as well as into his external world, or, as Claude Bernard has phrased it, into his milieu interieur and into his milieu exterieur. Now there is some method to my folly, and it amounts to this. We know a great deal about the disease rheumatic fever and about its devastating effects within the body of its victim. But we do not know a great deal, indeed only a very little, about the victim within whose body the disease effects its devastations. I said—we know a great deal about the disease itself. In preparation for this talk I "re-surveyed the literature" and I found it, as I have known it to be, not only enormous in quantity but most impressive in quality. It is literally studded with masterpieces of etiologic research, of clinical surveys, of pathologic studies, of follow-up surveys, of epidemiologic analyses, and of therapeutic enterprises. In my review of the literature I came upon some old and esteemed friends whose works I had witnessed "in the making," the studies, for example, of Wyckoff, and those of Alfred Cohn; Claire Ling's penetrating statistical analyses, Pearl Raymond's biologic speculations, May Wilson's classical and encyclopedic résumé of knowledge—and upon a host of others, too numerous, really, to catalogue.

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