scholarly journals Correction: A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags

2016 ◽  
Vol 14 (38) ◽  
pp. 9158-9158
Author(s):  
B. Söveges ◽  
T. Imre ◽  
T. Szende ◽  
Á. L. Póti ◽  
G. B. Cserép ◽  
...  
Keyword(s):  
Systematic Study ◽  
Protein Labeling ◽  
Vinyl Sulfone ◽  
Fluorogenic Probes

Correction for ‘A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags’ by B. Söveges, et al., Org. Biomol. Chem., 2016, 14, 6071–6078.

A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags

2016 ◽  
Vol 14 (25) ◽  
pp. 6071-6078 ◽  
Author(s):  
B. Söveges ◽  
T. Imre ◽  
T. Szende ◽  
Á. L. Póti ◽  
G. B. Cserép ◽  
...  
Keyword(s):  
Systematic Study ◽  
Click Reaction ◽  
Protein Labeling ◽  
Vinyl Sulfone ◽  
P Protein ◽  
Fluorogenic Probes

Protein labeling by cycloocytynylated vinyl sulfone linkers is fast and thiol-selective, and subsequent click reaction with fluorogenic azides generates intensive fluorescence.

Development of an effective protein-labeling system based on smart fluorogenic probes

2019 ◽  
Vol 24 (4) ◽  
pp. 443-455 ◽  
Author(s):  
Shahi Imam Reja ◽  
Masafumi Minoshima ◽  
Yuichiro Hori ◽  
Kazuya Kikuchi
Keyword(s):  
Protein Labeling ◽  
Fluorogenic Probes ◽  
Labeling System

scholarly journals Design, Synthesis and Evaluation of Enzyme-Responsive Fluorogenic Probes Based on Pyridine-Flanked Diketopyrrolopyrrole Dyes

2020 ◽  
Author(s):  
Sébastien Jenni ◽  
Flavien Ponsot ◽  
Pierre Baroux ◽  
Lucille Collard ◽  
Takayuki Ikeno ◽  
...  
Keyword(s):  
Charge State ◽  
Systematic Study ◽  
Fluorescent Probes ◽  
Penicillin G ◽  
Redox Enzymes ◽  
Design Synthesis ◽  
Rapid Construction ◽  
Fluorogenic Dyes ◽  
Fluorogenic Probes ◽  
Scope Of Application

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

2018 ◽  
Vol 54 (76) ◽  
pp. 10758-10761 ◽  
Author(s):  
Elodie Decuypère ◽  
Margaux Riomet ◽  
Antoine Sallustrau ◽  
Sarah Bregant ◽  
Robert Thai ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Fluorescent Sensors ◽  
Protein Labeling ◽  
Turn On ◽  
Fluorogenic Probes ◽  
Coumarin Compounds

Sydnone-coumarin compounds are interesting turn-on fluorogenic probes for protein labeling.

Coumarin-Based Fluorogenic Probes for No-Wash Protein Labeling

2014 ◽  
Vol 126 (50) ◽  
pp. 14005-14008 ◽  
Author(s):  
Yingche Chen ◽  
Christopher M. Clouthier ◽  
Kelvin Tsao ◽  
Miroslava Strmiskova ◽  
Hugo Lachance ◽  
...  
Keyword(s):  
Protein Labeling ◽  
Fluorogenic Probes

SNAP-tag fluorogenic probes for wash free protein labeling

2017 ◽  
Vol 28 (10) ◽  
pp. 1911-1915 ◽  
Author(s):  
Shuang Leng ◽  
Qing-Long Qiao ◽  
Yue Gao ◽  
Lu Miao ◽  
Wu-Guo Deng ◽  
...  
Keyword(s):  
Protein Labeling ◽  
Free Protein ◽  
Fluorogenic Probes

scholarly journals Design, Synthesis and Evaluation of Enzyme-Responsive Fluorogenic Probes Based on Pyridine-Flanked Diketopyrrolopyrrole Dyes

2020 ◽  
Author(s):  
Sébastien Jenni ◽  
Flavien Ponsot ◽  
Pierre Baroux ◽  
Lucille Collard ◽  
Takayuki Ikeno ◽  
...  
Keyword(s):  
Charge State ◽  
Systematic Study ◽  
Fluorescent Probes ◽  
Penicillin G ◽  
Redox Enzymes ◽  
Design Synthesis ◽  
Rapid Construction ◽  
Fluorogenic Dyes ◽  
Fluorogenic Probes ◽  
Scope Of Application

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

2019 ◽  
Vol 55 (31) ◽  
pp. 4582-4585 ◽  
Author(s):  
Lucie Plougastel ◽  
Manas R. Pattanayak ◽  
Margaux Riomet ◽  
Sarah Bregant ◽  
Antoine Sallustrau ◽  
...  
Keyword(s):  
Cell Imaging ◽  
Cycloaddition Reaction ◽  
Protein Labeling ◽  
Turn On ◽  
Fluorogenic Probes

Fluorogenic sydnone-based turn-on probes allow efficient labeling of proteins and cell imaging through a bioorthogonal strained promoted sydnone–alkyne cycloaddition reaction.

Coumarin-Based Fluorogenic Probes for No-Wash Protein Labeling

2014 ◽  
Vol 53 (50) ◽  
pp. 13785-13788 ◽  
Author(s):  
Yingche Chen ◽  
Christopher M. Clouthier ◽  
Kelvin Tsao ◽  
Miroslava Strmiskova ◽  
Hugo Lachance ◽  
...  
Keyword(s):  
Protein Labeling ◽  
Fluorogenic Probes
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