Small molecule Hedgehog pathway antagonists

2017 ◽  
Vol 15 (14) ◽  
pp. 3046-3059 ◽  
Author(s):  
Trieu N. Trinh ◽  
Eileen A. McLaughlin ◽  
Christopher P. Gordon ◽  
Ilana R. Bernstein ◽  
Victoria J. Pye ◽  
...  
Keyword(s):  
Small Molecule ◽  
Signalling Pathway ◽  
Hedgehog Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway ◽  
Ethyl Amine

Leveraging our quinolone-1-(2H)-one based Hedgehog signalling pathway (HSP) inhibitors we have developed two new classes of HSP inhibitors based on: l-tryptophan and benzo[1,3]dioxol-5-ylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine.

scholarly journals The role of kinases in the Hedgehog signalling pathway

EMBO Reports ◽  
2008 ◽  
Vol 9 (4) ◽  
pp. 330-336 ◽  
Author(s):  
Reid A Aikin ◽  
Katie L Ayers ◽  
Pascal P Thérond
Keyword(s):  
Signalling Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

scholarly journals The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy

2013 ◽  
Vol 15 (2) ◽  
Author(s):  
Mun Hui ◽  
Aurélie Cazet ◽  
Radhika Nair ◽  
D Neil Watkins ◽  
Sandra A O'Toole ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Signalling Pathway ◽  
Breast Development ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

Overexpression of the Hedgehog Signalling Pathway in Head and Neck Squamous Cell Carcinoma

Onkologie ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 1-1 ◽  
Author(s):  
Kamelia Dimitrova ◽  
Matthaeus Stoehr ◽  
Faramarz Dehghani ◽  
Andreas Dietz ◽  
Gunnar Wichmann ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Signalling Pathway ◽  
Neck Squamous Cell Carcinoma ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

scholarly journals Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 ◽  
Vol 10 (20) ◽  
pp. 1315-1318 ◽  
Author(s):  
P.W. Ingham ◽  
S. Nystedt ◽  
Y. Nakano ◽  
W. Brown ◽  
D. Stark ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway
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