scholarly journals The role of kinases in the Hedgehog signalling pathway

EMBO Reports ◽  
2008 ◽  
Vol 9 (4) ◽  
pp. 330-336 ◽  
Author(s):  
Reid A Aikin ◽  
Katie L Ayers ◽  
Pascal P Thérond
Keyword(s):  
Signalling Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism

2014 ◽  
Vol 82 (5) ◽  
pp. 728-738 ◽  
Author(s):  
L.C. Gregory ◽  
C. Gaston-Massuet ◽  
C.L. Andoniadou ◽  
G. Carreno ◽  
E.A. Webb ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Signalling Pathway ◽  
Hedgehog Signalling ◽  
Midline Defects ◽  
Hedgehog Signalling Pathway ◽  
Congenital Hypopituitarism ◽  
Sonic Hedgehog Signalling

scholarly journals The Role of the Hedgehog Signalling Pathway in Sporadic Medulloblastoma ♦ 762

1998 ◽  
Vol 43 ◽  
pp. 132-132
Author(s):  
R Mae Gailani ◽  
John Bukowski ◽  
Heidi Karpen ◽  
David A Reardon
Keyword(s):  
Signalling Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

Small molecule Hedgehog pathway antagonists

2017 ◽  
Vol 15 (14) ◽  
pp. 3046-3059 ◽  
Author(s):  
Trieu N. Trinh ◽  
Eileen A. McLaughlin ◽  
Christopher P. Gordon ◽  
Ilana R. Bernstein ◽  
Victoria J. Pye ◽  
...  
Keyword(s):  
Small Molecule ◽  
Signalling Pathway ◽  
Hedgehog Pathway ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway ◽  
Ethyl Amine

Leveraging our quinolone-1-(2H)-one based Hedgehog signalling pathway (HSP) inhibitors we have developed two new classes of HSP inhibitors based on: l-tryptophan and benzo[1,3]dioxol-5-ylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine.

scholarly journals Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhuo Xie ◽  
Mudan Zhang ◽  
Gaoshi Zhou ◽  
Lihui Lin ◽  
Jing Han ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Treatment Options ◽  
Critical Role ◽  
Signalling Pathway ◽  
Hedgehog Signalling Pathway ◽  
Inflammatory Bowel ◽  
Effective Drugs

AbstractThe Hedgehog (Hh) signalling pathway plays a critical role in the growth and patterning during embryonic development and maintenance of adult tissue homeostasis. Emerging data indicate that Hh signalling is implicated in the pathogenesis of inflammatory bowel disease (IBD). Current therapeutic treatments for IBD require optimisation, and novel effective drugs are warranted. Targeting the Hh signalling pathway may pave the way for successful IBD treatment. In this review, we introduce the molecular mechanisms underlying the Hh signalling pathway and its role in maintaining intestinal homeostasis. Then, we present interactions between the Hh signalling and other pathways involved in IBD and colitis-associated colorectal cancer (CAC), such as the Wnt and nuclear factor-kappa B (NF-κB) pathways. Furthermore, we summarise the latest research on Hh signalling associated with the occurrence and progression of IBD and CAC. Finally, we discuss the future directions for research on the role of Hh signalling in IBD pathogenesis and provide viewpoints on novel treatment options for IBD by targeting Hh signalling. An in-depth understanding of the complex role of Hh signalling in IBD pathogenesis will contribute to the development of new effective therapies for IBD patients.

scholarly journals The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy

2013 ◽  
Vol 15 (2) ◽  
Author(s):  
Mun Hui ◽  
Aurélie Cazet ◽  
Radhika Nair ◽  
D Neil Watkins ◽  
Sandra A O'Toole ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Signalling Pathway ◽  
Breast Development ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway

Overexpression of the Hedgehog Signalling Pathway in Head and Neck Squamous Cell Carcinoma

Onkologie ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 1-1 ◽  
Author(s):  
Kamelia Dimitrova ◽  
Matthaeus Stoehr ◽  
Faramarz Dehghani ◽  
Andreas Dietz ◽  
Gunnar Wichmann ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Signalling Pathway ◽  
Neck Squamous Cell Carcinoma ◽  
Hedgehog Signalling ◽  
Hedgehog Signalling Pathway
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