Reversibility of the thia-Michael reaction of cytotoxic C5-curcuminoid and structure–activity relationship of bis-thiol-adducts thereof

2016 ◽  
Vol 14 (45) ◽  
pp. 10683-10687 ◽  
Author(s):  
Aki Kohyama ◽  
Michihiro Fukuda ◽  
Shunsuke Sugiyama ◽  
Hiroyuki Yamakoshi ◽  
Naoki Kanoh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Michael Reaction ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Structure Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Structure Reactivity Relationship ◽  
Relationship Of

A panel of GO-Y030-bis-thiol-adducts were synthesized and the structure–reactivity relationship regarding the retro thia-Michael reaction as well as the cell growth inhibitory activity against human colon cancer HCT116 were evaluated.

Structure-activity relationship of a novel pentapeptide with cancer cell growth-inhibitory activity

2010 ◽  
Vol 16 (5) ◽  
pp. 242-248 ◽  
Author(s):  
Masakatsu Kamiya ◽  
Keisuke Oyauchi ◽  
Yoshinori Sato ◽  
Takuya Yokoyama ◽  
Mofei Wang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cancer Cell Growth ◽  
Structure Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Relationship Of

Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer

2016 ◽  
Vol 478 (2) ◽  
pp. 739-745 ◽  
Author(s):  
Bin Li ◽  
Peng Chen ◽  
Yanxiang Chang ◽  
Jingpeng Qi ◽  
Hui Fu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Tumor Cell ◽  
Human Colon ◽  
Tumor Cell Growth ◽  
Human Colon Cancer

Brosimone I, an isoprenoid-substituted flavonoid, induces cell cycle G1phase arrest and apoptosis through ROS-dependent endoplasmic reticulum stress in HCT116 human colon cancer cells

2019 ◽  
Vol 10 (5) ◽  
pp. 2729-2738 ◽  
Author(s):  
Yueliang Zhao ◽  
Yue Zhou ◽  
Mingfu Wang
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Growth ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Cell Growth Inhibition ◽  
Human Colon Cancer ◽  
Artocarpus Heterophyllus ◽  
Human Colon Cancer Cells

Brosimone I, an isoprenoid-substituted flavonoid fromArtocarpus heterophyllus, induces cell growth inhibition through the induction of ROS-mediated increased cytosolic Ca2+, ER stress, and the activation of the CaMKK-AMPK pathway.

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