scholarly journals Direct subphthalocyanine conjugation to bombesin vs. indirect conjugation to its lipidic nanocarrier

2016 ◽  
Vol 14 (19) ◽  
pp. 4511-4518 ◽  
Author(s):  
Yann Bernhard ◽  
Elodie Gigot ◽  
Victor Goncalves ◽  
Mathieu Moreau ◽  
Nicolas Sok ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Functional Group ◽  
Reactive Functional Group ◽  
Second Chance

Azido-liposomes give fluorophores/contrast agents with no reactive functional group available on their backbone a second chance to be (indirectly) bioconjugated (with bombesin).

Construction of Nonbiofouling Biofunctional Glass Surface by Self-Assembled Monolayer and Graft Hydrophilic Polymer

2008 ◽  
Vol 47-50 ◽  
pp. 1343-1346 ◽  
Author(s):  
Zong Bin Liu ◽  
Bei Zhang ◽  
Brian Yu Fung Pow ◽  
Mo Yang ◽  
Arthur Fuk Tak Mak
Keyword(s):  
Graft Polymerization ◽  
Functional Group ◽  
Substrate Surface ◽  
Surface Modifications ◽  
Activation Process ◽  
Self Assembled Monolayer ◽  
Functional Part ◽  
Reactive Functional Group ◽  
Self Assembled ◽  
Glass Surfaces

This paper introduces a new method of surface modification by self-assembled monolayer (SAM) and polymer monolayer grafting. Since most of the glass surfaces lack the reactive functional group, an activation process with 3-(trimethoxysilyl)propyl methacrylate(TPM) is used in our experiment to generate the vinyl reactive sites on the substrate surface for further graft polymerization. The TPM saline layer acts as the “anchor” part to link the functional part onto the surface of substrate. The paper summarizes the surface modifications by the polymerizations of PEGMA, AA(Acrylic acid) and NVP(Nitrogen-vinyl-2-pyrrolidone) respectively and their applications for protein adsorption and cell adhesion through a series of measurements. In previous research, AA and NVP had also been adopted for surface treatment and had achieved good results. The substrate can be glass, alumina, silicon, metals or stainless steel. We choose glass as our substrate during the experiment.

Functionalization of porphyrins: towards the synthesis of bifunctional chelates for bismuth coordination

2010 ◽  
Vol 14 (05) ◽  
pp. 412-420 ◽  
Author(s):  
Zakaria Halime ◽  
Sébatien Balieu ◽  
Btissam Najjari ◽  
Mohammed Lachkar ◽  
Thierry Roisnel ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
Functional Group ◽  
Acid Ethyl Ester ◽  
Phenyl Group ◽  
Ester Group ◽  
Reactive Functional Group ◽  
Amine Function ◽  
Electron Withdrawing Group ◽  
Bifunctional Chelates

We report the condensation of 3-chloromethyl-benzoyl chloride with two atropisomers ααββ and αβαβ of meso-5,10,15,20-tetrakis-(2-amino)phenylporphyrin (TAPP), followed by the reaction of the anion of either cyano-acetic acid ethyl ester or (4-nitro-phenyl)-acetic acid ethyl ester to prepare various pre-organized strapped porphyrins. These two reagents were selected as both allow the easy formation of the anion in the α position of the ester group while their electron-withdrawing group (EWG) can be further transformed in a reactive functional group. In the ααββ series, this reaction leads to three isomeric porphyrins differing only by the location of their ethoxycarbonyl groups, oriented either towards the center of the porphyrin or maintained outside of the cavity. In the αβαβ series, as expected, a single porphyrin is obtained in which both straps bear an ethoxycarbonyl group, precursor of a hanging carboxylic function and a cyano or a 4-nitro-phenyl group, which can be reduced to an amine function, suitable for the coupling on a biomolecule.

Self-Assembly of Functionalized [2]Catenanes Bearing a Reactive Functional Group on either One or Both Macrocyclic ComponentsFrom Monomeric [2]Catenanes to Polycatenanes†

1998 ◽  
Vol 31 (2) ◽  
pp. 295-307 ◽  
Author(s):  
Stephan Menzer ◽  
Andrew J. P. White ◽  
David J. Williams ◽  
Martin Bělohradský ◽  
Christoph Hamers ◽  
...  
Keyword(s):  
Self Assembly ◽  
Functional Group ◽  
Reactive Functional Group

Biomedical Applications of Gold Nanoparticles Functionalized Using Hetero-Bifunctional Poly(ethylene glycol) Spacer

2004 ◽  
Vol 845 ◽  
Author(s):  
Wei Fu ◽  
Dinesh Shenoy ◽  
Jane Li ◽  
Curtis Crasto ◽  
Graham Jones ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Functional Group ◽  
Thiol Group ◽  
Poly Ethylene Glycol ◽  
Surface Attachment ◽  
Quenching Effect ◽  
Reactive Functional Group ◽  
Poly Ethylene

ABSTRACTTo increase the targeting potential, circulation time, and the flexibility of surface-attached biomedically-relevant ligands on gold nanoparticles, hetero-bifunctional poly(ethylene glycol) (PEG, MW 1, 500) was synthesized having a thiol group on one terminus and a reactive functional group on the other. Coumarin, a model fluorescent dye, was conjugated to the PEG spacer and gold nanoparticles were modified with coumarin-PEG-thiol. Surface attachment of coumarin through the PEG spacer decreases the fluorescence quenching effect of gold nanoparticles. The results of cellular cytotoxicity and fluorescence confocal analyses showed that the PEG spacer modified nanoparticles were essentially non-toxic and could be efficiently internalized in the cells within one hour of incubation.

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