Photosensitizer cross-linked nano-micelle platform for multimodal imaging guided synergistic photothermal/photodynamic therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (33) ◽  
pp. 15323-15339 ◽  
Author(s):  
Xiaodong Liu ◽  
Guangbao Yang ◽  
Lifen Zhang ◽  
Zhuang Liu ◽  
Zhenping Cheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging

Self-assembled gold nanostar–NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy

2016 ◽  
Vol 4 (25) ◽  
pp. 4455-4461 ◽  
Author(s):  
Liangcan He ◽  
Joseph Dragavon ◽  
Suehyun Cho ◽  
Chenchen Mao ◽  
Adem Yildirim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Grand Challenge ◽  
Gold Nanostar ◽  
Self Assembled

A grand challenge for medicine is to develop tools to selectively image and treat diseased cells.

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

A nanosystem loaded with perfluorohexane and rose bengal coupled upconversion nanoparticles for multimodal imaging and synergetic chemo-photodynamic therapy of cancer

2020 ◽  
Vol 8 (9) ◽  
pp. 2488-2506 ◽  
Author(s):  
Hai-yan Wang ◽  
Li Hou ◽  
Hai-liang Li ◽  
Xu Wang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Irradiation ◽  
Rose Bengal ◽  
Multimodal Imaging ◽  
Upconversion Nanoparticles ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Release

A novel nanosystem (FURH-PFH-NPs) combined with LIFU and laser irradiation realized multimodal imaging, targeted release of HCPT, UCNPs-RB and synergetic chemo-photodynamic therapy of cancer.

scholarly journals A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

2020 ◽  
Vol 32 (28) ◽  
pp. 2003128
Author(s):  
Yifan Zhang ◽  
Shaowei Bo ◽  
Tao Feng ◽  
Xialing Qin ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging

A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

2019 ◽  
Vol 31 (21) ◽  
pp. 1806444 ◽  
Author(s):  
Yifan Zhang ◽  
Shaowei Bo ◽  
Tao Feng ◽  
Xialing Qin ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging

pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 9457-9467 ◽  
Author(s):  
Xunan Jing ◽  
Zhe Zhi ◽  
Liming Jin ◽  
Fei Wang ◽  
Youshen Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Multimodal Imaging ◽  
Great Promise ◽  
Stimuli Responsive

Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy.

A Near-Infrared Small Molecule Coupled with Rigidness and Flexibility for High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy

2021 ◽  
Author(s):  
Xiaozhen Li ◽  
Fang Fang ◽  
Bo Sun ◽  
Chao YIN ◽  
Jihua Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Application ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
High Performance ◽  
Near Infrared ◽  
The Other ◽  
Lesion Site ◽  
Comprehensive Information

Photodynamic therapy (PDT) synergized photothermal therapy (PTT) shows superior clinical application prospect than single PDT or PTT. On the other hand, multimodal imaging can delineate comprehensive information of lesion site...

scholarly journals Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

RSC Advances ◽  
2018 ◽  
Vol 8 (56) ◽  
pp. 32200-32210 ◽  
Author(s):  
Ying Tian ◽  
Ying Zhao ◽  
Wenfei Liu ◽  
Ying Liu ◽  
Yuxia Tang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Tumor Therapy

Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy.

scholarly journals Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

2020 ◽  
Author(s):  
Thomas J. van Rijssen ◽  
Elon H. C. van Dijk ◽  
Paula Scholz ◽  
Robert E. MacLaren ◽  
Sascha Fauser ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Central Serous Chorioretinopathy ◽  
Multimodal Imaging ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Final Visit ◽  
Chronic Central Serous Chorioretinopathy ◽  
Half Dose ◽  
Rpe Atrophy ◽  
The Mean

Abstract Purpose To evaluate the clinical outcomes after half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (cCSC) patients with pre-existent fovea-involving atrophy. Methods In this retrospective study, cCSC patients who had a window defect of the retinal pigment epithelium (RPE) on fluorescein angiography (FA), compatible with RPE atrophy, prior to half-dose PDT were included. Results Thirty-four cCSC eyes with typical findings of cCSC on multimodal imaging, and fovea-involving RPE atrophy on FA, were included. At the first visit after PDT (at a median of 1.8 months after half-dose PDT), 20 eyes (59%) had a complete resolution of SRF (p < 0.001), while this was the case in 19 eyes (56%) at final visit (median of 11.3 months after half-dose PDT; p < 0.001). The mean BCVA in Early Treatment of Diabetic Retinopathy Study letters was 71. 2 ± 15.9 at last visit before PDT, which increased to 74.1 ± 14.1 at first visit after PDT (p = 0.093, compared with baseline), and changed to 73.0 ± 19.1 at final visit (p = 0.392, compared with baseline). Both at first visit after PDT and at final visit, a significant decrease in subfoveal choroidal thickness was observed (p = 0.032 and p = 0.004, respectively). Conclusions Half-dose PDT in cCSC patients with pre-existing fovea-involving atrophy may lead to anatomical changes, but not to functional improvements. Ideally, cCSC should be treated with half-dose PDT before the occurrence of such atrophy.

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