An expedient microwave assisted regio- and stereoselective synthesis of spiroquinoxaline pyrrolizine derivatives and their AChE inhibitory activity

2017 ◽  
Vol 41 (2) ◽  
pp. 873-878 ◽  
Author(s):  
Adinarayana Murthy Akondi ◽  
Sowmya Mekala ◽  
Mannepalli Lakshmi Kantam ◽  
Rajiv Trivedi ◽  
L. Raju Chowhan ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Stereoselective Synthesis ◽  
Facile Synthesis ◽  
One Pot ◽  
Microwave Assisted ◽  
Ache Inhibitory Activity ◽  
The One

We report here an efficient protocol for the one-pot facile synthesis of spiro[indeno[1,2-b]quinoxaline-11,3′-pyrrolizine]heterocyclic scaffolds and their AChE inhibitory studies.

scholarly journals Microwave Assisted Three Component Reaction Conditions to Obtain New Thiazolidinones with Different Heterocyclic Skeletons

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 38
Author(s):  
Fernando J. Lorenzo ◽  
Romina A. Ocampo ◽  
Sandra D. Mandolesi
Keyword(s):  
Microwave Irradiation ◽  
Thioglycolic Acid ◽  
Aldehyde Group ◽  
Green Solvent ◽  
Reaction Products ◽  
Reaction Conditions ◽  
One Pot ◽  
Microwave Assisted ◽  
Three Component Reaction ◽  
The One

We present here a new proposal for the “one pot” generation of new 4-thiazolidinones (9a–e) through a multicomponent reaction under microwave irradiation conditions, using aromatic and heteroaromatic amines (8a–e), absolute ethanol as a “green” solvent and modifying the aldehyde group in the glycosidic residue, synthesized from D-mannitol. The study is focused in the variation of the irradiation times and the concentration of thioglycolic acid in order to study the possibility of controlling the structure and/or stereochemistry of the products formed in the reaction. Thiazolidinones 9a–d were obtained with a 69–82% The generation of the corresponding reaction products were monitored by TLC and CG-MS, taking reaction aliquots. The conditions reaction proved to be chemoselective depending on the excess of acid and irradiation times.

Facile Synthesis of Symmetrical Homonucleotides of Antiviral Nucleosides

2014 ◽  
Vol 1046 ◽  
pp. 96-99
Author(s):  
Jian Sun ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Facile Synthesis ◽  
One Pot ◽  
The One ◽  
Antiviral Nucleosides

A facile method for the one-pot preparation of homodinucleotides of AZT and d4T from corresponding nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole (DCI) as the activator has been developed.

Facile synthesis of CuCr2O4 spinel nanoparticles: a recyclable heterogeneous catalyst for the one pot hydroxylation of benzene

2014 ◽  
Vol 4 (12) ◽  
pp. 4232-4241 ◽  
Author(s):  
Shankha S. Acharyya ◽  
Shilpi Ghosh ◽  
Shubhadeep Adak ◽  
Takehiko Sasaki ◽  
Rajaram Bal
Keyword(s):  
Hydrothermal Synthesis ◽  
Synthesis Method ◽  
Facile Synthesis ◽  
One Pot ◽  
Nanoparticle Catalysts ◽  
Hydroxylation Of Benzene ◽  
The One ◽  
Recyclable Heterogeneous Catalyst ◽  
Selective Hydroxylation ◽  
Spinel Nanoparticles

A facile hydrothermal synthesis method is developed to prepare CuCr2O4 spinel nanoparticle catalysts with sizes between 25–50 nm for selective hydroxylation of benzene.

Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36775-36785 ◽  
Author(s):  
C. P. Baburajeev ◽  
Chakrabhavi Dhananjaya Mohan ◽  
Govindagouda S. Patil ◽  
Shobith Rangappa ◽  
Vijay Pandey ◽  
...  
Keyword(s):  
Cuprous Oxide ◽  
Inhibitory Activity ◽  
Bond Formation ◽  
One Pot ◽  
Carbazole Derivatives ◽  
One Pot Synthesis ◽  
The One ◽  
New Compounds ◽  
Bond Formation Reactions

In this study, we report the one-pot synthesis of substituted carbazole derivatives using nano cuprous oxide as a catalyst and demonstrated the STAT3 inhibitory activity of new compounds.

scholarly journals Microwave Assisted One Pot Synthesis of Tetrazole Based 3-hydroxy-4H-chromen-4-ones by modified Algar-Flynn-Oyamada reaction and their Antimicrobial activity

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
ASHOK DONGAMANTI ◽  
Nagaraju Nalaparaju ◽  
Sarasija Madderla ◽  
Vijaya Lakshmi Bommidi
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Klebsiella Pneumonia ◽  
Good Activity ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Antimicrobial Studies ◽  
The One

In the present work, we report the one pot synthesis of tetrazole based 3-hydroxy-4H-chromen-4-ones 3(a-g) from  4-(1H-tetrazol-5-yl)benzaldehyde and 2-hydroxy acetophenone using KOH and H2O2 by modified Algar-Flynn-Oyamada reaction under conventional and microwave irradiation conditions. In this technique, flavonols are synthesized without isolating chalcones, in good yields. All the synthesized compounds were characterized by IR, NMR, MS and elemental. All newly synthesized compounds were screened for their in-vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. The results of antimicrobial studies revealed that most of the compounds exhibit good activity.

scholarly journals A Facile Synthesis and Biological Screening of Pyrimidine Derivatives under Ultrasonic Irradiations by ZnCr2O4 Nano-Particles Catalyst

2021 ◽  
Vol 11 (1) ◽  
pp. 2996-3005
Keyword(s):  
Biological Activities ◽  
Aromatic Aldehydes ◽  
Vital Role ◽  
Nano Particles ◽  
Facile Synthesis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Biological Screening ◽  
Characterization Methods ◽  
The One

Using a recyclable catalyst, facile synthesis of pyrimidine derivatives (4a-e) is attributed through the one-pot multi-component reaction of 2-amino benzimidazole (1) substituted aromatic aldehydes (2a-e) with malononitrile (3) under ultrasonic irradiations. Synthesized derivatives might help society in getting more active pharmaceutical constituents. In this present work, series of substituted pyrimidine (4a-e) were synthesized and confirmed with different spectra characterization methods. The ZnCr2O4 nano-particles play a vital role in eco-friendly, highly efficient, recyclable heterogeneous nanocatalyst. Furthermore, synthesized pyrimidine derivatives showed significant biological activities. Advantages of this handy route are less reaction time, simple isolation, and highly yielded products.

scholarly journals Stereoselective synthesis of alkyl pyranosides on a laboratory scale

2020 ◽  
Vol 10 (3) ◽  
pp. 269-276
Author(s):  
Immo Serbian ◽  
Erik Prell ◽  
Ahmed Al-Harrasi ◽  
Rene Csuk
Keyword(s):  
Stereoselective Synthesis ◽  
Laboratory Scale ◽  
One Pot ◽  
The One

The one-pot reaction of per-acetylated glycopyranosyl bromides with alcohols in light-protected flask leads to the stereoselective synthesis of deacetylated alkyl pyranosides in good yields.

Facile synthesis of hierarchical pore foam catalysts with Brønsted–Lewis acid sites for the one-pot conversion of cellulose to 5-hydroxymethylfurfural

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 80368-80382 ◽  
Author(s):  
Yating Shen ◽  
Yunlei Zhang ◽  
Enwei Zhu ◽  
Yao Chen ◽  
Pei Jin ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Acid Sites ◽  
Facile Synthesis ◽  
Lewis Acid Sites ◽  
One Pot ◽  
Whole Process ◽  
Internal Phase ◽  
Hierarchical Pore ◽  
The One

The Whole process of synthesis of HPFCs by Pickering high internal phase emulsions and application in conversion of cellulose to HMF.

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