Surface proteomics on nanoparticles: a step to simplify the rapid prototyping of nanoparticles

2017 ◽  
Vol 2 (1) ◽  
pp. 55-64 ◽  
Author(s):  
J. Kuruvilla ◽  
A. P. Farinha ◽  
N. Bayat ◽  
S. Cristobal
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications ◽  
Engineered Nanoparticles ◽  
Target Cells

Engineered nanoparticles for biomedical applications require increasing effectiveness in targeting specific cells while preserving non-target cells safety.

Biomedical Applications of Nanoparticles

2022 ◽  
pp. 289-311
Author(s):  
Raghavv Raghavender Suresh ◽  
Shruthee Sankarlinkam ◽  
Sai Rakshana Karuppusami ◽  
Niraimathi Pandiyan ◽  
Suwetha Bharathirengan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Engineered Nanoparticles ◽  
Biological Molecules ◽  
Toxicological Evaluation ◽  
Nanodrug Delivery ◽  
Novel Drugs ◽  
Wide Range ◽  
Targeted Drug

In recent years, there has been significant growth and burgeoning interest in utilizing nanoparticles for various biomedical applications, including medical diagnostics, targeted drug delivery, tissue engineering, regenerative medicine, and biomedical textiles. In particular, nanoparticles functionalized with biological molecules have unique properties and are very effective in medical diagnostics. Besides that, nanoparticles have a wide range of therapeutic applications, including the development of nanodrug delivery systems, the design of novel drugs, as well as their contribution to the design of therapeutic materials. This chapter provides an overview of recent advancements in the biomedical applications of nanoparticles. Finally, this chapter discusses the challenges of the toxicological evaluation of engineered nanoparticles and the importance of conducting detailed studies on the synthesis of future nanomaterials to develop cutting-edge technologies for addressing a wide range of biomedical issues.

scholarly journals Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 1-12 ◽  
Author(s):  
Aslihan Gokaltun ◽  
Martin L. Yarmush ◽  
Ayse Asatekin ◽  
O. Berk Usta
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications ◽  
Gas Permeability ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Mature Stage ◽  
Major Drawback ◽  
Pdms Surface ◽  
Recent Advances ◽  
Hydrophobic Recovery

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

Image Guided Automated Non-Prehensile Magnetic Micromanipulation of Cells

2015 ◽  
Author(s):  
Akash Das ◽  
Ajay D. Thakur ◽  
Atul Thakur
Keyword(s):  
Target Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Cell Manipulation ◽  
Target Cells ◽  
Image Guided ◽  
Targeted Drug ◽  
And Control ◽  
Minimal Adverse Effect ◽  
Ferromagnetic Particles

Biomedical applications like cell manipulation and targeted drug delivery require automated micro-manipulation of biological material. Magnetic micro-manipulation has high actuation speed and minimal adverse effect on cell viability. Ferromagnetic particles, actuated via magnetic field, are used to push a target cell. The process is however cumbersome therefore require automation. This paper reports design, fabrication, and control of an image guided automated non-prehensile magnetic micromanipulation system. The developed system consists of ferromagnetic microspheres (henceforth referred to as microbots) which are actuated via independently controlling currents in four solenoids placed in a quadrupole configuration. We use image based localization for determining the microbot and target cell locations. We developed feedback planner which invokes either of the two maneuvers, namely, push or align to move microbot in order to push the cell towards the goal location. Instead of customize microtools we use simple spherical shaped microbots for pushing target cells.

Precision investment casting: A state of art review and future trends

2016 ◽  
Vol 230 (12) ◽  
pp. 2143-2164 ◽  
Author(s):  
Sunpreet Singh ◽  
Rupinder Singh
Keyword(s):  
Rapid Prototyping ◽  
Investment Casting ◽  
Biomedical Applications ◽  
Medical Science ◽  
Future Research ◽  
Fused Deposition Modelling ◽  
Future Trends ◽  
Fused Deposition ◽  
Cast Specimen ◽  
State Of Art

Investment casting process is known to its capability of producing clear net shape, high-dimensional accuracy and intricate design. Consistent research effort has been made by various researchers with an objective to explore the world of investment casting. Literature review revealed the effect of processing parameters on output parameters of cast specimen. This article highlights the advancements made and proposed at each step of investment casting and its hybridization with other process. Besides, investment casting has always been known to manufacture parts such as weapons, jewellery item, idols and statues of god and goddess since 3000 BC; this article reviews the present applications and trends in combination of rapid prototyping technique as integrated investment casting to serve in medical science. Advancements in shell moulding with incorporation of fibre and polymer, development of alternative feedstock filament to fused deposition modelling are duly discussed. The aim of this review article is to present state of art review of investment casting since 3200 BC. This article is organized as follows: in section ‘Introduction’, introduction to investment casting steps is given along with researches undertaken at each step; in section ‘Rapid prototyping technique’, background is given on the concept of rapid prototyping technique by examining the various approaches taken in the literature for defining rapid prototyping technique; section ‘Biomedical applications of RPT’ presents the medicine or biomedical applications of investment casting and rapid prototyping technique; section ‘Future trends’ provides some perspectives on future research and section ‘Conclusion’ closes the article by offering conclusions.

Modern Trends in Rapid Prototyping for Biomedical Applications

2015 ◽  
Vol 2 (4-5) ◽  
pp. 3409-3418 ◽  
Author(s):  
Deepen Banoriya ◽  
Rajesh Purohit ◽  
R.K. Dwivedi
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications

scholarly journals Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2282
Author(s):  
Estefania Gonzalez Solveyra ◽  
Rikkert J. Nap ◽  
Kai Huang ◽  
Igal Szleifer
Keyword(s):  
Surface Functionalization ◽  
Biomedical Applications ◽  
Rational Design ◽  
Structural Organization ◽  
Engineered Nanoparticles ◽  
Control Surface ◽  
Biological Macromolecules ◽  
Wide Range ◽  
Weak Polyelectrolytes ◽  
And Control

Surface functionalization with end-tethered weak polyelectrolytes (PE) is a versatile way to modify and control surface properties, given their ability to alter their degree of charge depending on external cues like pH and salt concentration. Weak PEs find usage in a wide range of applications, from colloidal stabilization, lubrication, adhesion, wetting to biomedical applications such as drug delivery and theranostics applications. They are also ubiquitous in many biological systems. Here, we present an overview of some of the main theoretical methods that we consider key in the field of weak PE at interfaces. Several applications involving engineered nanoparticles, synthetic and biological nanopores, as well as biological macromolecules are discussed to illustrate the salient features of systems involving weak PE near an interface or under (nano)confinement. The key feature is that by confining weak PEs near an interface the degree of charge is different from what would be expected in solution. This is the result of the strong coupling between structural organization of weak PE and its chemical state. The responsiveness of engineered and biological nanomaterials comprising weak PE combined with an adequate level of modeling can provide the keys to a rational design of smart nanosystems.

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